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Signalling Mechanisms — from Transcription Factors to Oxidative Stress pp 65–76Cite as

A Novel Form of Type-IVA cAMP Phosphodiesterase found in rat brain

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Part of the book series: NATO ASI Series ((ASIH,volume 92))

Abstract

Cyclic AMP (cAMP) plays a pivotal role in controlling cell functioning mediating the action of a number of hormones (Sutherland, 1972; Dumont et al, 1989). In such systems binding of a hormone to its receptor stimulates adenylate cyclase to increase synthesis of cAMP. Cyclic AMP then elicits the appropriate cellular response via activation of cAMP-dependent protein kinase (Scott, 1991). Alternatively it may be extruded from the cell (reviewed by Barber and Butcher, 1983 and Brunton and Heasley, 1988) or inactivated. The sole means of its inactivation is through the action of cAMP phosphodiesterases (PDEs) which hydrolyse cAMP to 5′AMP (Beavo, 1990; Houslay and Kilgour, 1990; Conti and Swinnen, 1990). Therefore, cAMP phosphodiesterases play a key role in cAMP metabolism and hence the associated signalling systems.

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References

  • Barber, R. and Butcher, R.W. (1983) Adv. Cyclic Nucleotide Research 15 119-135.

    CAS  Google Scholar 

  • Beavo, J.A. (1990) in ’Cyclic Nucleotide Phosphodiesterases: Structure, Regulation and Drug Action’ Molecular Pharmacology of Cell Regulation series Vol. 2. Beavo, J.A. and Houslay, M.D. eds. pp 3 - 15, John Wiley and Sons Ltd., pubs, Chichester and New York.

    Google Scholar 

  • Bradford, M.M. (1976) Anal. Biochem. 72 248 - 254

    Article  PubMed  CAS  Google Scholar 

  • Branton, L.L. and Heasley, L.E. (1988) Methods Enzymology 159 83 - 93

    Article  Google Scholar 

  • Conti, M and Swinnen, J.V. (1990) in ’Cyclic Nucleotide Phosphodiesterases: Structure, Regulation and Drug Action’ Molecular Pharmacology of Cell Regulation series Vol. 2. Beavo, J.A. and Houslay, M.D. eds. pp 243 - 266, John Wiley and Sons Ltd., pubs, Chichester and New York.

    Google Scholar 

  • Conti, M., Jin, C., Monaco, L., Repaske, D.R. and Swinnen, J.V. (1991) Endocrine Reviews 12 218 - 234.

    Article  PubMed  CAS  Google Scholar 

  • Davis, R.L., Takayusu, H., Eberwine, M and Myres J. (1989) PNAS 86 M 3604 - 3608.

    Google Scholar 

  • Davis, R.L. (1990) in ‘Cyclic Nucleotide Phosphodiesterases: Structure Regulation and Drug Action’ Molecular Pharmacology of Cell Regulation series Vol. 2. Beavo, J.A. and Houslay, M.D. eds. pp 227 - 241, John Wiley and Sons Ltd., pubs, Chichester and New York.

    Google Scholar 

  • Dumont, J.E., Jauniaux, J-C. and Roger, P. (1989) TIBS 14 67 - 71

    PubMed  CAS  Google Scholar 

  • Houslay, M.D. and Kilgour, E. (1990) in ‘Cyclic Nucleotide Phosphodiesterases: Structure, Regulation and Drug Action’ Molecular Pharmacology of Cell Regulation series Vol. 2. Beavo, J.A. and Houslay, M.D. eds. pp 185 - 226, John Wiley and Sons Ltd., pubs, Chichester and New York.

    Google Scholar 

  • Lavan, B.E., Lakey, T. and Houslay, M. D. (1990) Biochem. Pharmacol. 38 4123–4136

    Article  Google Scholar 

  • Lobban, M., Shakur, Y., Beattie, J. and Houslay, M.D. (1994) Submitted.

    Google Scholar 

  • Marchmont, R.J. and Houslay, M.D. (1980) Biochem J. 187 381 - 392

    PubMed  CAS  Google Scholar 

  • Pooley, L., Lobban, M., Shakur, Y., Horton, Y., Wilson, M., Beattie, J., Reed, R., and Houslay M.D. (1994). In preparation.

    Google Scholar 

  • Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular cloning. A laboratory manual pp 18.47 – 18.45

    Google Scholar 

  • Scott, J.D. (1991) Pharmacol. Ther. 14 1 – 24.

    Google Scholar 

  • Shakur, Y., Pryde, J.G. and Houslay, M.D. (1993) Biochem J. 292. 677 – 686.

    PubMed  CAS  Google Scholar 

  • Shakur, Y., Wilson, M., Pooley, L, Lobban, M., Campbell, A.M., Beattie, J., Daley, C. and Houslay, M.D. (1994). In press.

    Google Scholar 

  • Sutherland, E.W. (1972) Science 17 401 – 408

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Molecular Pharmacology Group, Department of Biochemistry, University of Glasgow, Glasgow, Gl2 8QQ, Scotland, UK

    Linda Pooley & Miles D. Houslay

Authors
  1. Linda Pooley
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  2. Miles D. Houslay
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Editor information

Editors and Affiliations

  1. Department of Molecular and Cell Biology, University of California, 251 Life Science Addition, 94720, Berkeley, CA, USA

    Lester Packer

  2. Centre for Biomembranes and Lipid Enzymology, Utrecht University, Padualaan 8, 3584 CH, Utrecht, The Netherlands

    Karel W. A. Wirtz

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© 1995 Springer-Verlag Berlin Heidelberg

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Pooley, L., Houslay, M.D. (1995). A Novel Form of Type-IVA cAMP Phosphodiesterase found in rat brain. In: Packer, L., Wirtz, K.W.A. (eds) Signalling Mechanisms — from Transcription Factors to Oxidative Stress. NATO ASI Series, vol 92. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79675-3_7

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  • DOI: https://doi.org/10.1007/978-3-642-79675-3_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79677-7

  • Online ISBN: 978-3-642-79675-3

  • eBook Packages: Springer Book Archive

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