Abstract
Phosphatidic acid phosphohydrolase [PAP; E.C.3.1.3.4] catalyses the dephosphorylation of phosphatidic acid (PA) into diacylglycerol. Regulation of PAP activity is thought to play a prominent role in controlling the rate of glycerolipid biosynthesis by limiting the supply of diacylglycerol, the precursor for triacylglycerol, phosphatidylcholine and phosphatidylethanolamine (Brindley, 1984; Martin et al, 1986). PAP can be regulated chronically by hormonal action, mediated at the level of enzyme synthesis and breakdown (Pittner et al, 1985), and in the short-term by translocation from the cytosol to the endoplasmic reticulum (Brindley, 1984) where it is thought to be metabolically active. Translocation onto the endoplasmic reticulum is induced by fatty-acids and their CoA esters (Brindley, 1984; Martin-Sanz et al, 1984).
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© 1995 Springer-Verlag Berlin Heidelberg
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Fleming, I.N., Yeaman, S.J. (1995). Phosphatidic Acid Phosphohydrolase: Its Role in Cell Signalling. In: Packer, L., Wirtz, K.W.A. (eds) Signalling Mechanisms — from Transcription Factors to Oxidative Stress. NATO ASI Series, vol 92. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79675-3_6
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DOI: https://doi.org/10.1007/978-3-642-79675-3_6
Publisher Name: Springer, Berlin, Heidelberg
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