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Interleukin lα and Tumor Necrosis Factor-α modulate the nuclear phosphoinositide signaling system

  • Sandra Marmiroli
  • Alberto Bavelloni
  • Irene Faenza
  • Rashmi Sood
  • Spartaco Santi
  • Stefania Cecchi
  • Nadir M. Maraldi
  • Andrea Ognibene
Conference paper
Part of the NATO ASI Series book series (volume 92)

Abstract

Growing interest has been currently focused on the role of phospholipids in signal transduction and cell growth. It is now well established that the breakdown products of several plasma membrane phospholipids act as signal molecules, i.e. as intracellular second messengers or as agonists that modulate cell functions. Despite the fact that phosphoinositides are a very minor fraction of membrane phospholipids, well known examples of phospholipid-derived signaling molecules include diacylglycerol and inositol trisphosphate, which are rapidly generated from PIP2 by the action of a specific phospholipase C following stimulation of cell-surface receptors.

Keywords

Nuclear Envelope Nuclear Matrix Nuclear Compartment Inositol Trisphosphate Nuclear Matrix Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Sandra Marmiroli
    • 1
  • Alberto Bavelloni
    • 2
  • Irene Faenza
    • 2
  • Rashmi Sood
    • 1
    • 2
  • Spartaco Santi
    • 1
  • Stefania Cecchi
    • 1
  • Nadir M. Maraldi
    • 1
    • 2
  • Andrea Ognibene
    • 2
  1. 1.Istituto di Citomorfologia Normale e PatologicaC.N.R.BolognaItaly
  2. 2.Laboratorio di Biologia Cellulare e Microscopia ElettronicaI.O.R.BolognaItaly

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