Interleukin lα and Tumor Necrosis Factor-α modulate the nuclear phosphoinositide signaling system
Growing interest has been currently focused on the role of phospholipids in signal transduction and cell growth. It is now well established that the breakdown products of several plasma membrane phospholipids act as signal molecules, i.e. as intracellular second messengers or as agonists that modulate cell functions. Despite the fact that phosphoinositides are a very minor fraction of membrane phospholipids, well known examples of phospholipid-derived signaling molecules include diacylglycerol and inositol trisphosphate, which are rapidly generated from PIP2 by the action of a specific phospholipase C following stimulation of cell-surface receptors.
KeywordsBurning Hydrolysis Osteosarcoma Inositol Bombesin
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