Zusammenfassung
Dahlbäck et al. [1] berichteten über das verminderte Ansprechen auf aktiviertes Protein C (APC) in einem aktivierten partiellen Thromboplastinzeit-Test (APTT) als Ursache familiärer Thrombophilie. Dieses Phänomen wurde als APC-Resistance (APC-R) bezeichnet und wird als Quotient (Ratio, RS) der APTT mit APC und der APTT ohne APC-Zusatz im Calciumchlorid angegeben. Als Ursache dieser APC-R wurde eine Punktmutation (Leiden) im Gen des Faktor V von Bertina et al. [2] beschrieben.
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Literatur
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© 1996 Springer-Verlag Berlin Heidelberg
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Halbmayer, W.M., Haushofer, A., Schön, R., Fischer, M. (1996). Die Prävalenz der APC-Resistance bei Patienten mit Insulten, venösen Thrombosen und bei gesunden Probanden. In: Scharrer, I., Schramm, W. (eds) 25. Hämophilie-Symposion Hamburg 1994. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79648-7_21
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