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Antigenic specificities of “antiphospholipid” autoantibodies

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Systemic Lupus Erythematosus

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Abstract

“Antiphospholipid” autoantibodies (aPL) are strongly associated with recurrent thrombosis, fetal loss, and thrombocytopenia [51]. This association has been termed the antiphospholipid antibody syndrome and may occur in patients with systemic lupus erythematosus (SLE) and related diseases, or as a primary syndrome in patients without other autoimmune diseases. Although direct evidence for the pathogenicity of aPL is lacking, a number of observations have led investigators to hypothesize that aPL may directly contribute to a thrombotic diathesis: (1) unlike antinuclear autoantibodies, aPL appear to target components of cells surface membranes that are accessible to circulating antibodies; (2) the putative antigens, anionic phospholipids, are critically involved in hemostatic and thrombotic reactions that occur on the surface of vascular endothelial cells, platelets, and other blood cells; (3) animal models of the aPL syndrome have been developed via passive transfer of human aPL [6, 9]; (4) a recent prospective study has demonstrated that the presence of aPL precedes the first episode of venous thrombosis by months to years in a population of apparently normal individuals [27]; and (5) the risk of developing clinical manifestations of the aPL syndrome correlates directly with the level of aPL [27, 30].

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  1. Division of Rheumatology and Immunology, Thurston Arthritis Research Center, The University of North Carolina at Chapel Hill, CB#7280, Room 932 FLOB, Chapel Hill, NC, 27599-7280, USA

    Robert A. S. Roubey

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  1. Division d’Hématologie, Centre de Transfusion Sanguine, Hôpital Cantonal Universitaire, 25, rue Micheli-du-Crest, CH-1211, Geneva 4, Switzerland

    Peter A. Miescher

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Roubey, R.A.S. (1995). Antigenic specificities of “antiphospholipid” autoantibodies. In: Miescher, P.A. (eds) Systemic Lupus Erythematosus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79622-7_6

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