Abstract
Follicular dendritic cells (FDC) have been noted as one of unique immunological accessory cells. They are localized within lymphoid follicles as an intricate cellular meshwork that helps to maintain follicular structure. FDC also have the capability to trap and retain antigens in the form of immune complexes on their surface for long periods, providing unprocessed antigens to germinal center B cells in the form of iccosomes (immune complex-coated bodies); In this chapter, the morphological features and the cytochemical and immunological phenotypes of FDC are reviewed and discussed within the context of recent topics and controversial issues.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Barklay AN (1981) Different reticular elements in rat lymphoid tissue identified by localization of la, Thy-1 and MRC OX-2 antigens. Immunology 44: 727–736
Carbone A, Manconi R, Poletti A, Colombatti A, Tirelli U, Volpe R (1986) S-100 protein, fibronectin and laminin immunostaining in lymphomas of follicular center cell origin. Cancer 58: 2169–2176
Carbone A, Poletti A, Manconi R, Gloghini A, Volpe R (1987) Heterogeneous in situ immunophenotyping of follicular dendritic reticulum cells in alignant lymphomas of B-cell origin. Cancer 60: 2919–2926
Carbone A, Poletti A, Manconi R, Gloghini A, Volpe R (1988) Heterogeneous immunostaining patterns of follicular dendritic reticulum cells in human lymphoid tissue with selected antibodies reactive with differenct cell lineages. Hum Pathol 19: 51–56
Chen LL, Adams JC, Steinman RM (1978) Anatomy of germinal centers in mouse spleen, with special reference to “follicular dendritic cells.” J Cell Biol 77: 148–164
Cocchia D, Tiberio G, Santarelli R, Michetti F (1983) S-100 protein in “follicular dendritic” cells of rat lymphoid organs. An immunohistochemical and immunocytochemical study. Cell Tissue Res. 230: 95–103
Degawa N, Maeda K, Nagashima R, Matsuda M, Arai S, Imai Y (1994) Immunohistochemical analysis on tonsillar tissues of the patients with IgA nephropathy. I Localization of IgA and the related molecules. Dendritic Cells 4: 101–111
Dijkstra CD, Van den Berg TK (1991) The follicular dendritic cell: possible regulatory roles of associated molecules. Res Immunol 142: 227–231
Ennas MG, Chilosi M, Scarpa A, Lantini MS, Cadeddu G, Fiore-Donati L (1989) Isolation of multicellular complexes of follicular dendritic cells and lymphocytes: immunophenotypical characterization, electron microscopy and culture studies. Cell Tissue Res 257: 9–15
Freedman AS, Munro JM, Rice GE, Bevilacqua MP, Morimoto C, Mclntyre BW, Rhynhart K, Pober JS, Nadler LM (1990) Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110. Science 249: 1030–1033
Gerdes J, Stein H, Mason DY, Ziegler A (1983) Human dendritic reticulum cells of lymphoid follicles: their antigenic profile and their identification as multinucleated giant cells. Virchow Arch [B] 42: 161–172
Gray D, Kosco M, Stockinger B (1991) Novel pathway of antigen presentation for the maintenance of memory. Int Immunol 3: 141–148
Halstensen TS, Mollnes TE, Brandtzaeg P (1988) Terminal complement complex ( TCC) and S-protein (vitronectin) on follicular dendritic cells in human lymphoid tissues. Immunology 65: 193–197
Heinen E, Lilet-Leclercq C, Mason Dy, Stein H, Boniver J, Radoux D, Kinet-Denoel C, Simar LJ (1984) Isolation of follicular dendritic cells from human tonsils and adenoids. II. Immunocytochemical characterization. Eur J Immunol 14: 267–273
Heinen E, Radoux D, Kinet-Denoel C, Moeremans M, De Mey J, Simar LJ (1985a) Isolation of follicular dendritic cells from human tonsils and adenoids. III. Analysis of their Fc receptors. Immunology 54: 777–784
Humphrey JH, Grennan D (1982) Isolation and properties of spleen follicular dendritic cells. In: Nieuwenhuis, van den Broek, Hanna (eds) In vivo immunology. Plenum, New York, pp 823–827
Imai Y, Terashima K, Matsuda M, Dobashi M, Maeda K, Kasajima K (1983) Reticulum cell and dendritic reticulum cell -origin and function-. Rec Adv RES Res 21: 51–81
Humphrey JH, Grennan D (1982) Isolation and properties of spleen follicular dendritic cells. In: Nieuwenhuis, van den Broek, Hanna (eds) In vivo immunology. Plenum, New York, pp 823–827
Imai Y, Yamakawa M, Masuda A, Sato T, Kasajima T (1986) Function of the follicular dendritic cell in the germinal center of lymphoid follicles. Histol Histophathol 1: 341–353
Imai Y, Matsuda M, Maeda K, Yamakawa M, Dobashi M, Satoh H, Terashima K (1991) Dendritic cells in lymphoid tissues—their morphology, antigenic profiles and functions. In: Imai Y, Tew JG, Hoefsmit ECM (eds) Dendritic cells in lymphoid tissues. Excepta Medica, Amsterdam, pp 3–13
Jeurissen SHM, Dijkstra CD (1986) Characteristics and functional aspects of nonlymphoid cells in rat germinal centers, recognized by two monoclonal antibodies ED5 and ED6. Eur J Immunol 16: 562–568
Johnson GD, Hardie DL, Ling NR, MacLennan ICM (1986) Human follicular dendritic cells (FDC): a study with monoclonal antibodies ( MoAb ). Clin Exp Immunol 64: 205–213
Koopman G, Parmentier HK, Schuurman H-J, Newman W, Meijer CJLM, Pals ST (1991) Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways. J Exp Med 173: 1297–1304
Kosco MH, Tew JG, Szakal AK (1986) Antigenic phenotyping of isolated and in situ rodent follicular dendritic cells ( FDC) with emphasis on the ultrastructural demonstration of la antigens. Anat Rec 215: 201–213
Kosco MH, Pflugfelder E, Gray D (1992) Follicular dendritic cell-dependent adhesion and proliferation of B cells in vitro. J Immunol 148: 2331–2339
Tanaka Y (1986) Immunocytochemical study of human lymphoid tissues with monoclonal antibodies against S-100 protein subunits. Virchows Arch [A] 410: 125–132
Tew JG, Thorbecke J, Steinman RM (1982) Dendritic cells in the immune response: characteristics and recommended nomenclature (a report from the reticuloendothelial society committee on nomenclature). JRES 31: 371–380
Tsunoda R, Kojima M (1987) A light microscopical study of isolated follicular dendritic cell-clusters in human tonsil. Acta Pathol Jpn 37: 575–585
Tsunoda R, Nakayama M, Heinen E, Miyake K, Suzuki K, Okamura H, Sugai N, Kojima M (1993) Emperipholesis of lymphoid cells by human follicular dendritic cells in vitro. Adv Exp Med Biol 329: 365–370
Van den Berg TK, Dopp EA, Breve JJP, Kraal G, Dijkstra CD (1989) The heterogeneity of the reticulum of rat peripheral lymphoid organs identified by monoclonal antibodies. Eur J Immunol 19: 1747–1756
van der Valk P, van der Loo EM, Jansen J, Daha MR, Meijer CJLM (1984) Analysis of lymphoid and dendritic cells in human lymph node, tonsil and spleen. A study using monoclonal and heterogeneous antibodies. Virchow Arch [B] 45: 169–185
Wacker H-H, Radzun HJ, Mielke V, Parwaresch MR (1987) Selective recognition of rat follicular dendritic cells (dendritic reticulum cells) by a new monoclonal antibody Ki-M4R in vitro and in vivo. J Leukoc Biol 41: 70–77
Wood GS, Turner RR, Shiurba RA, Eng L, Warnke RA (1985) Human dendritic cells and macrophages. In situ immunophenotypic definition of subsets that exhibit specific morphologic and microenvironmental characterisitics. Am J pathol 119: 73–82
Würzner R, Xu H, Franzke M, Schulze M, Peters JH, Götze O (1991) Blood dendritic cells carry terminal complement complexes on their cell surface as detected by newly developed neoepitope-specific monoclonal antibodies. Immunology 74: 132–138
Yamakawa M, Takagi M, Tajima K, Ohe S, Osanai T, Kudo S, Ito M, Imai Y (1991) Localization of blood coagulation factors and fibrinolysis factors within lymphoid germinal centers in human lymph nodes. Histochemistry 96: 123–127
Yoshida K, Van den Berg TK, Dijkstra CD (1993) Two functionally different follicular dendritic cells in secondary lymphoid follicles of mouse spleen, as revealed by CR 1/2 and FcyRII-mediated immunecomplex trapping. Immunology 80: 34–39
Zutter MM (1991) Immunolocalization of integrin receptors in normal lymphoid tissues. Blood 77: 2231–2236
Zwirner J, Felber E, Schmidt P, Riethmüller G, Feucht HE (1989) Complement activation in human lymphoid germinal centers. Immunology 66: 270–277
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Maeda, K., Matsuda, M., Imai, Y. (1995). Follicular Dendritic Cells: Structure as Related to Function. In: Kosco-Vilbois, M.H. (eds) An Antigen Depository of the Immune System: Follicular Dendritic Cells. Current Topics in Microbiology and Immunology, vol 201. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79603-6_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-79603-6_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-79605-0
Online ISBN: 978-3-642-79603-6
eBook Packages: Springer Book Archive