Skip to main content
SpringerLink
Log in

Mechanism of Immune Complex Trapping by Follicular Dendritic Cells

  • Chapter
An Antigen Depository of the Immune System: Follicular Dendritic Cells

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 201))

Abstract

The follicular dendritic cell (FDC) is a major constituent of the microenvironment of the lymphoid follicle. FDC have the characteristic and unique property of binding antigens in the form of antigen-antibody complexes and retaining these complexes, without ingestion, for long periods of time. The presence of antigen-antibody complexes, also called immune complexes, on FDC is believed to play a crucial role in the development of B cell memory and the affinity maturation of the antibody response against T cell-dependent antigens.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Aubry JP, Pochon S, Graber P, Jansen KU, Bonnefoy JY (1992) CD21 is a ligand for CD23 and regulates IgE production. Nature 358: 505–507

    Article  PubMed  CAS  Google Scholar 

  • Böttger EC, Metzger S, Bitter-Suermann D, Stevenson G, Kleindienst S, Burger R (1986) Impaired humoral immune response in complement C3-deficient guinea pigs: absence of secondary antibody response. Eur J Immunol 16: 1231–1235

    Article  PubMed  Google Scholar 

  • Braun M, Heinen E, Cormann N, Kinet-Donoel C, Simar LJ (1987) Influence of immunoglobulin isotypes and lymphoid cell phenotype on the transfer of immune complexes to follicular dendritic cells. Cell Immunol 107: 99–106

    Article  PubMed  CAS  Google Scholar 

  • Brown JC, DeJesus DG, Holborow EJ, Harris G (1970) Lymphocyte mediated transport of aggregated human y-globulin into germinal centre areas of normal mouse spleen. Nature 228: 367–369

    Article  PubMed  CAS  Google Scholar 

  • Bijsterbosch MK, Klaus GGB (1985) Crosslinking of surface Ig and Fc receptors on B lymphocytes inhibits stimulation of inositol phospholipid breakdown via the antigen receptors. J Exp Med 162: 1825

    Article  PubMed  CAS  Google Scholar 

  • Carter RH, Fearon DT (1992) CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science 256: 105–107

    Article  PubMed  CAS  Google Scholar 

  • Carter RG, Spycher MO, Yin CNG, Hoffman R, Fearon DT (1988) Synergistic interaction between complement receptor type 2 and membrane IgM on B lymphocytes. J Immunol 141: 457–463

    PubMed  CAS  Google Scholar 

  • Carter RG, Tuveson DA, Park DJ, Rhee SG, Fearon DT (1991) The CD19 complex of lymphocytes: activation of phospholipase C by a protein tyrosine kinase-dependent pathway that can be enhanced by the membrane IgM complex. J Immunol 147: 3663–3671

    PubMed  CAS  Google Scholar 

  • Cerny A, Zinkernagel RM, Groscurth P (1988) Development of dendritic cells in lymph nodes of B-celldepleted mice. Cell Tissue Res 254: 449–454

    Article  PubMed  CAS  Google Scholar 

  • Chen LL, Frank AM, Adams JC, Steinman RM (1978) Distribution of horseradish peroxidase ( HRP)-anti-HRP immune complexes in mouse spleen with special reference to follicular dendritic cells. J Cell Biol 79: 184–199

    Article  PubMed  CAS  Google Scholar 

  • Collie MH (1974) The localization of soluble antigen in the spleen of Xenopus laevis. Experientia 30: 1205–1206

    Article  PubMed  CAS  Google Scholar 

  • Damoiseaux JGMC, Dopp EA, Neefjes, Beelan RHJ, Dijkstra CD (1989) Heterogeneity of macrophages in the rat evidenced by variability in determinants. Two new anti-rat macrophage antibodies against a heterodimer of 160-kD and 95-kD (CD11 b/CD18). J Leukocyte Biol 46: 556 –564

    PubMed  CAS  Google Scholar 

  • Delcayre AX, Salas F, Mathur S, Kovats K, Lotz M, Lemhardt W (1991) Epstein-Barr virus/complement C3d receptor is an interferon a receptor. EMBO J 10: 919–926

    PubMed  CAS  Google Scholar 

  • Dickler HB (1976) Lymphocyte receptors for immunoglobulin. Adv Immunol 24: 167

    Article  PubMed  CAS  Google Scholar 

  • Dijkstra CD, Van Tilburg NJ, Dopp EA (1982) Ontogenetic aspects of immune-complex trapping in the spleen and popliteal lymph nodes of the rat. Cell Tissue Res 223: 545–552

    Article  PubMed  CAS  Google Scholar 

  • Dijkstra CD, Te Velde AA, Van Rooijen N (1983) Localization of horseradish (HRP)-anti-HRP complexes in cryostat sections: influence of endotoxin on trapping of immune complexes in the spleen of the rat. Cell Tissue Res 232: 1–7

    Article  PubMed  CAS  Google Scholar 

  • Dresser DW, Popham AM (1979) The influence of T cells on the initiation and expression of immunological memory. Immunology 38: 265

    PubMed  CAS  Google Scholar 

  • Dukor P, Hartmann KU (1973) Hypothesis: bound C3 as a second signal for B cell activation. Cell Immunol 7: 349–356

    Article  PubMed  CAS  Google Scholar 

  • Eikelenboom P, Kroese FGM, Van Rooijen N (1983) Immune complex-trapping cells in the spleen of the chicken. Cell Tissue Res 231: 377–386

    Article  PubMed  CAS  Google Scholar 

  • Embling PH, Evans H, Guttierez C, Holborow EJ, Johns P, Johnson PM, Papamichail M, Stanworth DR (1978) Structural requirements for immunoglobulin aggregates to localize in germinal centres. Immunology 34: 781–786

    PubMed  CAS  Google Scholar 

  • Enriquez-Rincon F, Klaus GGB (1984) Follicular trapping of hapten-erythrocyte-antibody complexes in mouse spleen. Immunology 52: 107–116

    PubMed  CAS  Google Scholar 

  • Enriquez-Ricon F, Andrew E, Parkhouse RME, Klaus GGB (1984) Suppression of follicular trapping of antigen-antibody complexes in mice treated with anti-IgM or anti-lgD antibodies from birth. Immunology 53: 713–719

    Google Scholar 

  • Erdei A, Melchers F, Schultz T, Dierich M (1985) The action of human C3 in soluble or cross-linked form with resting and activated murine B lymphocytes. Eur J Immunol 15: 184–188

    Article  PubMed  CAS  Google Scholar 

  • Farkas Al, Medgyesi GA, Fust G, Miklos K, Gergely J (1982) Immunogenicity of antigen complexed with antibody. I. Role of different isotypes. Immunology 45: 483–492

    Google Scholar 

  • Fearon DT (1993) The CD19-CR2-TAPA-1 complex, CD45 and signalling by the antigen receptor of B lymphocytes. Curr Opinion Immunol 5: 341–348

    Article  CAS  Google Scholar 

  • Fearon DT, Ahearn JM (1989) Complement receptor type 1 (C3b/C4b receptor; CD35) and complement receptor type 2 (C3d/Epstein-Barr Virus receptor; CD21). In: Lambris JD (ed) The third component of complement. Chemistry and biology. Springer, Berlin Heidelberg New York, pp 83–98 (Current topics in microbiology and immunology, vol 153 )

    Google Scholar 

  • Fingeroth JD (1990) Comparative structure and evolution of murine CR2. J Immunol 144: 3458–3467

    PubMed  CAS  Google Scholar 

  • Fingeroth JD, Benedict MA, Levy DN, Strominger JL (1989) Identification of murine complement receptor type 2. Proc Natl Acad Sci USA 86: 242–246

    Article  PubMed  CAS  Google Scholar 

  • Gajl-Peczalaska KJ, Fish AJ, Meuwisse HJ, Frommel D, Good RA (1969) Localization of immunological complexes fixing betalc ( C3) in germinal centers of lymph nodes. J Exp Med 130: 1367–1374

    Google Scholar 

  • Gerdes J, Stein H, Mason DY, Ziegler A (1983) Human dendritic reticulum cells of lymphoid follicles: their antigenic profile and their identification as multinucleated giant cells. Virchows Arch B 42: 161–172

    PubMed  CAS  Google Scholar 

  • Gray D, Skarvall H (1988) B cell memory is short-lived in the absence of antigen. Nature 336: 70–73

    Article  PubMed  CAS  Google Scholar 

  • Gray D, McConnel I, Kumararatne DS, MacLennan ICM, Humphrey JH, Bazin H (1984a) Marginal zone cells express CR1 and CR2 receptors. Eur J Immunol 14: 40–52

    Article  Google Scholar 

  • Gray D, Kumararatne DS, Lortan J, Khan M, MacLennan ICM (1984b) Relation of intrasplenic migration of marginal zone B cells to antigen localization of follicular dendritic cells. Immunology 52: 659–669

    PubMed  CAS  Google Scholar 

  • Groeneveld PHP, Eikelenboom P, Van Rooijen N (1983) Mechanism of follicular trapping: similarities and differences in trapping of antibody-complexed antigens and carbon particles in the follicles of the spleen. J Reticuloend Soc 33: 109–117

    CAS  Google Scholar 

  • Halstensen TS, Mollnes TE, Brandtzaeg P (1988) Terminal complement complex ( TCC) and S-protein (vitronectin) on follicular dendritic cells in human lymphoid tissues. Immunology 65: 193–197

    Google Scholar 

  • Hebell T, Ahearn JM, Fearon DT (1991) Suppression of the immune response by a soluble complement receptor. Science 254: 102–105

    Article  PubMed  CAS  Google Scholar 

  • Heinen E, Radoux D, Kinet-Denoel C, Moeremans M, De Mey J, Simar LJ (1985) Isolation of follicular dendritic cells from human tonsils and adenoids. III. Analysis of their Fc receptors. Immunology 54: 777–784

    Google Scholar 

  • Heinen E, Braun M, Coulie PG, Van Snick J, Moeremans M, Cormann N, Kinet-Denoel C, Simar LJ (1986a) Transfer of immune complexes from lymphocytes to follicular dendritic cells. Eur J Immunol 16: 167–172

    Article  PubMed  CAS  Google Scholar 

  • Heinen E, Cormann N, Kinet-Denoel C, Simar L (1986b) Lipopolysaccharide suppresses immune complex retention by FDC without cytological alterations. Immunol Lett 13: 323–327

    Article  PubMed  CAS  Google Scholar 

  • Heyman B (1990) The immune complex: possible ways of regulating the antibody response. Immunol Today 11: 310–313

    Article  PubMed  CAS  Google Scholar 

  • Heyman B, Pilstrom L, Shulman MJ (1988) Complement activation is required for IgM-mediated enhancement of the antibody response. J Exp Med 167: 1999

    Google Scholar 

  • Heyman B, Wiersma EJ, Kinoshita T (1990) In vivo inhibition of the antibody response by a complement receptor specific monoclonal antibody. J Exp Med 172: 665–668

    Article  PubMed  CAS  Google Scholar 

  • Holers VM, Kinoshita T, Molina H (1992) The evolution of mouse and human complement C3-binding proteins: divergence of form but conservation of function. Immunol Today 13: 231–236

    Article  PubMed  CAS  Google Scholar 

  • Humphrey JH, Franck MM (1967) Localization of non-microbial antigens in draining lymph nodes of tolerant normal and primed rabbits. Immunology 13: 87–95

    PubMed  CAS  Google Scholar 

  • Humphrey JH, Sundaram V (1984) The origin of follicular dendritic cells in the mouse and the mechanism of trapping of immune complexes. Eur J Immunol 14: 859–864

    Article  PubMed  CAS  Google Scholar 

  • Imai Y, Yamakawa M, Masuda A, Sato T, Kasajima T (1986) Function of the follicular dendritic cell in the germinal center of lymphoid follicles. Histol Histopathol 1: 341–353

    PubMed  CAS  Google Scholar 

  • Imazeki N, Senoo A, Fuse Y (1992) Is the follicular dendritic cell a primarily stationary cell? Immunology 76: 508–510

    PubMed  CAS  Google Scholar 

  • Jacob J, Kelsoe G, Rajewski K, Weiss U (1991) Intraclonal generation of antibody mutants in germinal centers. Nature 354: 389–392

    Article  PubMed  CAS  Google Scholar 

  • Johnson GD, Hardie DL, Ling NR, MacLennan ICM (1986) Human follicular dendritic cells (FDC): a study with monoclonal antibodies ( MoAb ). Clin Exp Immunol 64: 205–213

    Google Scholar 

  • Kamperdijk EWA, Dijkstra CD, Döpp EA (1987) Transport of immune complexes from the subcapsular sinus into the lymph node follicle of the rat. Immunology 147: 395

    Google Scholar 

  • Kapasi ZF, Burton GF, Schultz LD, Tew TG, Szakal AK (1993) Induction of functional follicular dendritic cells development in severe combined immunodeficiency mice. Influence of B and T cells. J Immunol 150: 2648

    Google Scholar 

  • Kapasi ZE, Kosco MH, Schultz LD, Tew JG, Szakal AK (1994) Cellular origin of follicular dendritic cells. Proceedings of the 11th germinal centre conference (in press)

    Google Scholar 

  • Kinoshita T, Takeda J, Hong K, Kozono H, Sakai H, Inoue K (1988) Monoclonal antibodies to mouse complement receptor type 1. J Immunol 140: 3066–3072

    PubMed  CAS  Google Scholar 

  • Kinoshita T, Thyphronitis G, Tsokos GC, Finkelman FD, Hong K, Sakai H, Inoue K (1990) Characterization of murine complement receptor type 2 and its immunological cross-reactivity with type 1 receptor. Int Immunol 2: 651–659

    Article  PubMed  CAS  Google Scholar 

  • Klaus GGB (1979) The generation of memory cells. III. Antibody class requirements for the generation of B memory cells. Immunology 37: 345–351

    PubMed  CAS  Google Scholar 

  • Klaus GGB, Humphrey JH (1977) The generation of memory cells. I. The role of C3 in the generation of memory cells. Immunology 33: 31–40

    PubMed  CAS  Google Scholar 

  • Klaus GGB, Humphrey JH (1986) A re-evaluation of the role of C3 in B cell activation. Immunol Today 7: 163–165

    Article  CAS  Google Scholar 

  • Klaus GGB, Pepys MB, Kitajima K, Askonas BA (1979) Activation of mouse complement by different classes of mouse antibody. Immunology 38: 687

    PubMed  CAS  Google Scholar 

  • Klaus GGB, Humphery JH, Kunkl A, Dongworth DW (1980) The follicular dendritic cell: its role in antigen presentation in the generation of immunological memory. Immunol Rev 53: 3–28

    Article  PubMed  CAS  Google Scholar 

  • Klaus GGB, Hawrylowicz CM, Holman M, Keeler KD (1984) Intact ( IgG) anti-lg antibodies activate B cells but inhibit the induction of DNA synthesis. Immunology 53: 693

    Google Scholar 

  • Klaus GGB, Bijsterbosch MK, O’Garra A, Harnett MM, Rigley KP (1987) Receptor signalling and crosstalk in B lymphocytes. Immunol Rev 99: 19–83

    Article  PubMed  CAS  Google Scholar 

  • Kosco MH, Tew JG, Szakal AK (1986) Antigenic phenotyping of isolated and in situ rodent follicular dendritic cells (FDC) with emphasis on the ultrastructural demonstration of la antigens. Anat Ree 215: 201–213

    Google Scholar 

  • Kroese FGM, Van Rooijen N (1983) Antigen trapping in the spleen of the turtle, Chrysemys scripta elegans. Immunology 49: 61–68

    Google Scholar 

  • Kroese FGM, Leceta J, Döpp EA, Herraez MP, Nieuwenhuis P, Zapata A (1985) Dendritic immune complex cells in the spleen of the snake, Python reticularis. Dev Comp Immunol 9: 641–652

    Google Scholar 

  • Kroese FGM, Wubbema AS, Nieuwenhuis P (1986) Germinal centre formation and follicular trapping in the spleen of lethally X-irradiated and reconstituted rats. Immunology 57: 99–104

    PubMed  CAS  Google Scholar 

  • Kroese FGM, Timens W, Nieuwenhuis P (1990) Germinal center reaction and B lymphocytes: morphology and function. Curr Top Pathol 84 (1): 103–148

    PubMed  Google Scholar 

  • Kunkl A, Klaus GGB (1981) The generation of memory cells. IV. Immunization with antigen-antibody complexes accelerates the development of memory cells, the formation of germinal centres and the maturation of antibody in the secondary response. Immunology 43: 371–378

    Google Scholar 

  • Kurtz CB, Paul MS, AegerterM, Weis JJ, Weis JH (1989) Murine complement receptor gene family. II. Identification and characterization of the murine homolog (Cr2) to human CR2 and its molecular linkage to Crry. J Immunol 143: 2058–2067

    Google Scholar 

  • Laman JD, Kors N, Van Rooijen N, Claassen E (1990) Mechanism of follicular trapping: localization of immune complexes and cell remnants after elimination and repopulation of different spleen cell populations. Immunology 71: 57–62

    PubMed  CAS  Google Scholar 

  • MacLennan ICM, Gray D (1986) Antigen-driven selection of virgin and memory B cells. Immunol Rev 91: 61–85

    Article  PubMed  CAS  Google Scholar 

  • Maeda K, Burton GF, Padgett DA, Conrad DH, Huff TF, Masuda A, Szakal AK, Tew JG (19S2) Murine follicular dendritic cells and low affinity Fc receptors for IgE (FceRII). J Immunol 148: 2340–2347

    Google Scholar 

  • Mandel TE, Phipps RP, Abbot AP, Tew JG (1981) Long-term antigen retention by dendritic cells in the popliteal lymph node of immunized mice. Immunology 43: 353–361

    PubMed  CAS  Google Scholar 

  • Matsumoto AK, Martin DR, Carter RH, Klickstein LB, Ahearn JM, Fearon DT (1993) Functional dissection of the CD21 /CD 19/TAPA–1 /Leu~13 complex of B lymphocytes. J Exp Med 178: 1407–1417

    Article  PubMed  CAS  Google Scholar 

  • Melchers F, Erdei A, SchultzT, Dierich MP (1985) Groth control of activated, synchronized murine B cells by the C3d fragment of human complement. Nature 317: 264–265

    Google Scholar 

  • Mitani S, Takagi K, Oka T, Mori S (1988) Increased immunoglobulin E Fc receptor bearing cells in the germinal centers of hyperimmunoglobulinemia E patients. Int Arch Allergy Immunol 87: 63

    Article  CAS  Google Scholar 

  • Mjaaland S, Fossum S (1987) The localization of antigen in lymph node follicles on congenitally athymic nude rats. Scand J Immunol 26: 141–147

    Article  PubMed  CAS  Google Scholar 

  • Molina H, Wong W, Kinoshita T, Brebber C, Foley S, Holers VM (1992) Distinct receptor and regulatory properties of recombinant mouse complement receptor 1 (CR1) and Crry, the two genetic homologues of human CR1. J Exp Med 175: 121–129

    Article  PubMed  CAS  Google Scholar 

  • Nossal GJV, Abbot A, Mitchell J, Lummus Z (1968) Antigens in immunity XV. Ultrastructural features of antigen capture in primary and secondary lymphoid follicles. J Exp Med 127: 227–235

    Google Scholar 

  • Papamichail M, Gutierrez C, Embling P, Johnson P, Holborow EJ, Pepys MB (1975) Complement dependence of localization of aggregated IgG in germinal centres. Scand J Immunol 4: 343–347

    Article  PubMed  CAS  Google Scholar 

  • Petrasch S, Perez-Alvarez C, Schmitz J, Kosco M, Brittinger G (1990) Antigenic phenotyping of human follicular dendritic cells isolated from nonmalignant and malignant lymphatic tissue. Eur J Immunol 20: 1013–1018

    Article  PubMed  CAS  Google Scholar 

  • Phipps RP, Mitchell GF, Mandel TE, Tew JG (1980) Antibody isotypes mediating antigen retention in passively immunized mice. Immunology 40: 459–466

    PubMed  CAS  Google Scholar 

  • Phipps RP, Mandel TE, Tew JG (1981) Effect of immunosuppressive agents on antigen retained in lymphoid follicles and collageneous tissue of immune mice. Cell Immunol 57: 505–516

    Article  PubMed  CAS  Google Scholar 

  • Pramoonjago P, Takeda J, Kim YU, Inoue K, Kinoshita T (1993) Ligand specificities of mouse complement receptor types 1 (CR1) and 2 (CR2) purified from spleen cells. Int Immunol 5: 337–343

    Article  PubMed  CAS  Google Scholar 

  • Radoux D, Kinet-Denoel C, Heinen E, Moeremans M, De Mey J, Simar LJ (1985) Retention of immune complexes by Fc receptors on mouse follicular dendritic cells. Scand J Immunol 21: 345–353

    Article  PubMed  CAS  Google Scholar 

  • Reynes M, Aubers JP, Cohen JHM, Audouin J, Tricottet V, Diebold J, Kazatchkine MD (1985) Human follicular dendritic cells express CR1, CR2, and CR3 complement receptor antigens. J Immunol 135: 2687–2694

    PubMed  CAS  Google Scholar 

  • Rosen H, Law SKA (1989) The leukocyte surface receptor(s) for the iC3b product of complement. In: Lambris JD (ed) The third component of complement. Chemistry and biology. Springer, Berlin Heidelberg New York, pp 99–122 (Current topics in microbiology and immunology, vol 153 )

    Google Scholar 

  • Schriever F, Freedman AS, Freeman, Messner E, Lee G, Daley J, Nadler LM (1989) Isolated human follicular dendritic cells display a unique antigenic phenotype. J Exp Med 169: 2043–2058

    Google Scholar 

  • Secombes CJ, Manning MJ, Ellis AE (1982) Localization of immune complexes and heat-aggregated immunoglobulin in the carp Cyprinus carpio L. Immunology 47: 101–105

    PubMed  CAS  Google Scholar 

  • Segal DM, Titus JA (1978) The subclass specificity for the binding of murine myeloma proteins to macrophage and lymphocyte cell lines and to normal spleen cells. J Immunol 120: 1395

    PubMed  CAS  Google Scholar 

  • Sellheyer K, Schwarting R, Stein H (1989) Isolation and antigenic profile of follicular dendritic cells. Clin Exp Immunol 78: 431–436

    PubMed  CAS  Google Scholar 

  • Simar LJ, Lilet-Leclercq C, Heinen E, Kinet-Denoel C, Radoux D (1984) Functional study of human tonsillar follicular dendritic cells. Acta Otorhinolaryngol Belg 38: 278–287

    PubMed  CAS  Google Scholar 

  • Sinclair NRS, Panoskaltis A (1987) Immunoregulation by Fc signals. A mechanism for self-nonself discrimination. Immunol Today 8: 76

    Google Scholar 

  • Szakal AK, Holmes KL, Tew JG (1983) Transport of immune complexes from the subcapsular sinus to lymph node follicles on the surface of non-phagocytotic cells, including cells with dendritic morphology. J Immunol 131: 1714

    PubMed  CAS  Google Scholar 

  • Szakal AK, Haley ST, Caffrey RE, Burton GF, Tew JG (1993) Lymph node antigen transport cell (ATC) phenotype. Abstract book of the 11th Germinal Centre Conference, 1993, Spa, Belgium, p 122

    Google Scholar 

  • Tanner J, Weis J, Fearon D, Whang Y, Kieff E (1987) Epstain-Barr virus gp350/220 binding to the B lymphocyte C3d receptor mediates absorption, capping, and endocytosis. Cell 50: 203–213

    Article  PubMed  CAS  Google Scholar 

  • Tew JG, Mandel TE, Miller GA (1979) Immune retention: immunological requirements for maintaining an easily degradable antigen in vivo. Aust J Exp Biol Med Sci 57: 401–414

    Google Scholar 

  • Tew JG, Phipps RP, Mandel TE (1980) The maintenance and regulation of the humoral immune response: persisting antigen and the role of follicular antigen-binding dendritic cells as accessory cells. Immunol Rev 53: 175–201

    Article  PubMed  CAS  Google Scholar 

  • Thyphronitis G, Kinoshita T, Inoue K, Sweinle JE, Tsokos GC, Metcalf ES, Finkelman FD, Balow JE (1991) Modulation of mouse complement receptors 1 and 2 suppresses antibody responses in vivo. J Immunol 147: 224–230

    PubMed  CAS  Google Scholar 

  • Tsokos GC, Lambris JD, Finkelman FD, Anastassiou ED, June CH (1990) Monovalent ligands of complement receptor 2 inhibit whereas polyvalent ligands enhance anti-lg-induced human B cell intracytoplasmic free calcium concentration. J Immunol 144: 1640–1645

    PubMed  CAS  Google Scholar 

  • Tuveson DA, Ahearn JM, Matsumoto AK, Fearon DT (1991) Molecular interactions of complement receptors on B lymphocytes: a CR1/CR2 complex distinct from the CR2/CD19 complex. J Exp Med 173: 1083–1089

    Article  PubMed  CAS  Google Scholar 

  • Tuveson DA, Carter RH, Soltoff SP, Fearon DT (1993) CD19 of B cells as a surrogate kinase insert region to bind phosphatidyl inositol 3-kinase. Science 260: 986–988

    Article  PubMed  CAS  Google Scholar 

  • Uckun FM, Burkhardt AL, Jarvis L, Jun X, Stealey B, Dibirdik I, Meyers DE, Tuel-Ahlgren L, Bolen JB (1993) Signal transduction through the CD19 receptor during discrete developmental stages of human B cell ontogeny. J Biol Chem 268: 21172–21184

    PubMed  CAS  Google Scholar 

  • Van den Berg TK, Dopp EA, Breve JJP, Kraal G, Dijkstra CD (1989) The heterogeneity of the reticulum of rat peripheral lymphod organs identified by monoclonal antibodies. Eur J Immunol 19: 1747–1756

    Article  PubMed  Google Scholar 

  • Van den Berg TK, Dopp EA, Daha MR, Kraal G, Dijkstra CD (1992) Selective inhibition of immune complex trapping by follicular dendritic cells with monoclonal antibodies against rat C3. Eur J Immunol 22: 957–962

    Article  PubMed  Google Scholar 

  • Van den Eertwegh AJM, Noelle RJ, Roy M, Shepherd DM, Aruffo A, Ledbetter JA, Boersma WJA, Claassen E (1993) In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines ant antibody production delineates sites of cognate T-B cell interactions. J Exp Med 178: 1555–1565

    Google Scholar 

  • Van Rooijen N (1975) Immune complexes in the spleen: the difference between competitive inhibition of immune complex trapping in spleen follicles and inhibition by paratyphoid vaccine. Immunol 28: 1155–1162

    Google Scholar 

  • Van Rooijen N, Claassen E, Eikelenboom P (1986) Is there a single differentiation pathway for all antibody-forming cells in the spleen. Immunol Today 7: 193–196

    Article  Google Scholar 

  • White RG, Henderson DC, Eslami MB, Nielsen KH (1975) Localization of a protein antigen in the chicken spleen: effects of various manipulative procedures on the morphogenesis of the germinal center. Immunology 28: 1–21

    PubMed  CAS  Google Scholar 

  • Wiersma EJ, Kinoshita T, Heyman B (1991) Inhibition of immunological memory and T-independent humoral responses by monoclonal antibodies specific for murine complement receptors. Eur J Immunol 21: 2501–2506

    Article  PubMed  CAS  Google Scholar 

  • Yoshida K, Van den Berg TK, Dijkstra CD (1993) Two functionally different follicular dendritic cells in secondary lymphoid follicles of mouse spleen, as revealed by CR1/2 and FcyRII-mediated immune complex trapping. Immunology 80: 34–39

    PubMed  CAS  Google Scholar 

  • Yoshida K, Van den Berg TK, Dijkstra CD (1994) The functional state of follicular dendritic cells in severe combined immunodeficient (SCID) mice: role of lymphocytes. Eur J Immunol 24: 464–468

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cell Biology and Immunology, Vrije University, Van Der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands

    T. K. Van den Berg & C. D. Dijkstra

  2. Department of Molecular Immunology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryomachi, Aoka-ku, Sendai, 980, Japan

    K. Yoshida

Authors
  1. T. K. Van den Berg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Yoshida
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. D. Dijkstra
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Glaxo Institute for Immunology, 14, Chemin des Aulx, 1228, Plan-les-Ouates Geneva, Switzerland

    Marie H. Kosco-Vilbois

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Van den Berg, T.K., Yoshida, K., Dijkstra, C.D. (1995). Mechanism of Immune Complex Trapping by Follicular Dendritic Cells. In: Kosco-Vilbois, M.H. (eds) An Antigen Depository of the Immune System: Follicular Dendritic Cells. Current Topics in Microbiology and Immunology, vol 201. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79603-6_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-79603-6_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79605-0

  • Online ISBN: 978-3-642-79603-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation