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Follicular Dendritic Cells: Origin and Function

  • E. Heinen
  • A. Bosseloir
  • F. Bouzahzah
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 201)

Abstract

The human immune system is made up of one trillion lymphocytes. Although dispersed throughout the organism, these cells behave as if they belonged to a single organ. To attain this homeostasis, the lymphoid cells home to and are controlled in lymphoid tissues where, in specific microenvironments, they communicate with each other or with accessory cells and proliferate, mature, or die under stringently controlled conditions. The germinal center microenvironments are among those controlling the B cells which, during the T-dependent humoral immune responses, undergo important phases of their life cycles: activation, proliferation, the isotype switch, affinity maturation, deactivation, apoptosis, etc. The follicular dendritic cells (FDC) are major components of the germinal center microenvironments. Here, we examine their origin and their influence on B cells in the light of recent experimental data.

Keywords

Immune Complex Lymphoid Cell Germinal Center Follicular Dendritic Cell Immunol Today 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • E. Heinen
    • 1
  • A. Bosseloir
    • 1
  • F. Bouzahzah
    • 1
  1. 1.Institute of Human HistologyUniversity of LiègeLiègeBelgium

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