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Assessing the Role of E1A in the Differential Oncogenicity of Group A and Group C Human Adenoviruses

  • Chapter
Book cover The Molecular Repertoire of Adenoviruses III

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 199/3))

Abstract

It was first shown In 1962 that human adenovirus (Ad) types 12 and 18 rapidly induce undifferentiated sarcomas in newborn hamsters (Huebner et al. 1962; Trentin et al. 1962). In the decade that followed this initial discovery, numerous investigators confirmed the finding and showed that such tumors could be induced in other rodent species and that, depending upon the route of inoculation, neurogenic, neuroepithelial, medulloblastic, adenocarcinomatous, and retino-blastoma-like tumors were induced. During that same period it was shown that most of the other human adenoviruses either do not induce tumors in rodents or do so slowly and with low efficiency. In fact, it is now known that of the five viral groups of human adenoviruses defined on the basis of nucleic acid homology (and most likely also the more recently identified enteric adenoviruses), only those of group A (Ad12, Ad18, and Ad31) are highly oncogenic. Viruses of group B (for example, Ad3 and Ad7) are weakly oncogenic and induce tumors slowly and with low frequency. Viruses of group C (Ad1, Ad2, and Ad5) are considered to be nononcogenic, and those of groups D and E which have been tested are likewise negative for tumor induction, with the signal exception of Ad9. It is of considerable interest that this virus induces mammary fibroadenomas, some of which progress into malignant tumors in female Wistar/Furth rats (Jonsson and Ankerst 1977).

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Authors and Affiliations

  1. Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA, 15213, USA

    J. Williams, M. Williams & C. Liu

  2. Department of Neurology, University of California, San Francisco, CA, 94143, USA

    G. Telling

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  1. J. Williams
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  2. M. Williams
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  3. C. Liu
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  4. G. Telling
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  1. Institut für Genetik, Universität zu Köln, Weyertal 121, 50931, Köln, Germany

    Walter Doerfler  & Petra Böhm  & 

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© 1995 Springer-Verlag Berlin Heidelberg

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Williams, J., Williams, M., Liu, C., Telling, G. (1995). Assessing the Role of E1A in the Differential Oncogenicity of Group A and Group C Human Adenoviruses. In: Doerfler, W., Böhm, P. (eds) The Molecular Repertoire of Adenoviruses III. Current Topics in Microbiology and Immunology, vol 199/3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79586-2_8

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  • DOI: https://doi.org/10.1007/978-3-642-79586-2_8

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