Does the EEG Measure Therapeutic Opioid Drug Effect?
In this chapter we discuss the extent to which the EEG reflects therapeutic opioid drug effect. For the hypnotics, the EEG has been used to control the depth of anesthesia via closed-loop administration. These systems will be discussed in the chapters by Professors Schwilden [1, 2] (median frequency) and Kenny (auditory-evoked potentials). That computerized systems are able to satisfactorily administer hypnotics based on direct feedback from EEG-derived measures suggests that the EEG is, in fact, a very reasonable measure of hypnotic drug effect. Thus, we will focus here on the EEG as a measure of the therapeutic effect of opioids.
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