Molecular Aspects of Cytochrome P450 2E1 and Its Roles in Chemical Toxicity
Cytochrome P450 2E1, previously known as P450LM3a, P450j, P450ac, or P450alc, has received a great deal of attention in recent years because of its vital role in the activation of many toxic chemicals (Yang, et al., 1992, Yang, et al., 1990, Guengerich, et al., 1991, Koop, 1992). In this chapter, the structure, catalytic activities, and regulation of this enzyme are discussed. Examples are used to illustrate this enzyme as a target for the interactions of many environmental chemicals. Although written in the form of a review, it is not intended to be a comprehensive review of the literature. Many of our own studies are used as examples to illustrate pertinent points.
KeywordsDiallyl Sulfide Phenethyl Isothiocyanate Tetraethylthiuram Disulfide Cytochrome P450IIEI Benzene Pyridine
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