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Molecular Aspects of Oxidative Drug Metabolizing Enzymes pp 181–192Cite as

Molecular Aspects of Cytochrome P450 2E1 and Its Roles in Chemical Toxicity

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Part of the book series: NATO ASI Series ((ASIH,volume 90))

Abstract

Cytochrome P450 2E1, previously known as P450LM3a, P450j, P450ac, or P450alc, has received a great deal of attention in recent years because of its vital role in the activation of many toxic chemicals (Yang, et al., 1992, Yang, et al., 1990, Guengerich, et al., 1991, Koop, 1992). In this chapter, the structure, catalytic activities, and regulation of this enzyme are discussed. Examples are used to illustrate this enzyme as a target for the interactions of many environmental chemicals. Although written in the form of a review, it is not intended to be a comprehensive review of the literature. Many of our own studies are used as examples to illustrate pertinent points.

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Author information

Authors and Affiliations

  1. Laboratory for Cancer Research College of Pharmacy, Rutgers University, Piscataway, NJ, 08855, USA

    Chung S. Yang & Jun-Yan Hong

Authors
  1. Chung S. Yang
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  2. Jun-Yan Hong
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Editor information

Editors and Affiliations

  1. Department of Biology, Middle East Technical University, Inönü Bulvari, Ankara, 06531, Turkey

    Emel Arinç

  2. Department of Toxicology, University of Connecticut Health Center, Farmington, Connecticut, 06032, USA

    John B. Schenkman

  3. Department of Toxicology, North Carolina State University, Raleigh, North Carolina, 27695, USA

    Ernest Hodgson

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© 1995 Springer-Verlag Berlin Heidelberg

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Yang, C.S., Hong, JY. (1995). Molecular Aspects of Cytochrome P450 2E1 and Its Roles in Chemical Toxicity. In: Arinç, E., Schenkman, J.B., Hodgson, E. (eds) Molecular Aspects of Oxidative Drug Metabolizing Enzymes. NATO ASI Series, vol 90. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79528-2_9

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  • DOI: https://doi.org/10.1007/978-3-642-79528-2_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79530-5

  • Online ISBN: 978-3-642-79528-2

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