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Molecular Biology of Cytochrome P-450: Evolution, Structure and Regulation

  • Conference paper
Book cover Molecular Aspects of Oxidative Drug Metabolizing Enzymes

Part of the book series: NATO ASI Series ((ASIH,volume 90))

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Abstract

Cytochrome P450 is a class of hemoproteins that function as the terminal monooxygenases in microsomal, mitochondrial, or cytosolic NADPH-dependent electron transport pathways. P450 genes are widely distributed in nature from bacteria to higher animals and plants. Each mammalian genome possesses at least 50 P450 genes located on various chromosomes. Mammalian P450s as a whole metabolize an uncountable number of endogenous and exogenous substrates, such as steroids, fatty acids, vitamin D3, drugs, toxicants, environmental pollutants, and so on (Gonzalez 1990). The P450 enzymes involved in biosynthesis of physiologically active compounds (steroid hormones, prostaglandins, bile acids, vitamins, thromboxane, etc) play critical roles in development and maintenance of normal animal life. Other P450s mainly work in detoxication systems to convert lipophilic xenobiotics to more water-soluble forms. Some of the products of these reactions are chemically unstable and often produce DNA adduct which may trigger chemical carcinogenesis.

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Author information

Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Tohoku University, Aoba-ku, Sendai 980, Japan

    Yoshiaki Fujii-Kuriyama & Osamu Gotoh

  2. Department of Biochemistry, Saitama Cancer Center Research Institute, Inamachi, Saitama 362, Japan

    Osamu Gotoh

Authors
  1. Yoshiaki Fujii-Kuriyama
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  2. Osamu Gotoh
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Editor information

Editors and Affiliations

  1. Department of Biology, Middle East Technical University, Inönü Bulvari, Ankara, 06531, Turkey

    Emel Arinç

  2. Department of Toxicology, University of Connecticut Health Center, Farmington, Connecticut, 06032, USA

    John B. Schenkman

  3. Department of Toxicology, North Carolina State University, Raleigh, North Carolina, 27695, USA

    Ernest Hodgson

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© 1995 Springer-Verlag Berlin Heidelberg

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Fujii-Kuriyama, Y., Gotoh, O. (1995). Molecular Biology of Cytochrome P-450: Evolution, Structure and Regulation. In: Arinç, E., Schenkman, J.B., Hodgson, E. (eds) Molecular Aspects of Oxidative Drug Metabolizing Enzymes. NATO ASI Series, vol 90. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79528-2_4

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  • DOI: https://doi.org/10.1007/978-3-642-79528-2_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79530-5

  • Online ISBN: 978-3-642-79528-2

  • eBook Packages: Springer Book Archive

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