Abstract
The mammalian flavin-containing monooxygenases (FMOs) comprise an important family of “phase I” xenobiotic-metabolizing enzymes. Although not as catalytically or structurally diverse as the cytochrome P450 super-family, the FMOs do metabolize a variety of exogenous compounds, including numerous drugs, pesticides, and other xenobiotics. The FMOs catalyze the oxidation of nitrogen, sulfur, and phosphorous atoms, but cannot carryout the oxidation of carbon (Ziegler, 1980). Like cytochrome P450, the FMOs utilize molecular oxygen as a substrate, NADPH as a source of electrons, produce water as one product, and are localized primarily to the endoplasmic reticulum of cells in a variety of tissues.
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References
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© 1995 Springer-Verlag Berlin Heidelberg
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Philpot, R.M., Atta-Asafo-Adjei, E., Nikbakht, K., Burnett, V., Lawton, M.P. (1995). Emergence of the Flavin-Containing Monooxygenase Gene Family: Molecular Biology, Structure, and Function. In: Arinç, E., Schenkman, J.B., Hodgson, E. (eds) Molecular Aspects of Oxidative Drug Metabolizing Enzymes. NATO ASI Series, vol 90. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79528-2_11
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DOI: https://doi.org/10.1007/978-3-642-79528-2_11
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