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Bioavailability of Therapeutically Used Hydrolytic Enzymes

  • P. Streichhan
  • W. van Schaik
  • G. Stauder
Conference paper

Abstract

Humoral efficacy of orally administered hydrolytic enzymes used as systemic therapeutic agents requires that they should be absorbed. However, measurements of absorption in enzymes based on the substance itself result in varying results. Different measuring methods produce hydrolytic enzymes absorption rates which do not shift within the normal range but differ with regard to the dose administered between thousandth parts and more than 50% (Table 1): immunological tests show the lowest rates (< 1%), enzyme substrate tests values of less than 10%, and, radioactivity measurements using labeled enzymes (by means of radioactivity attached secondarily to biocatalysts) the most highest transfer values. The differences arise from viewing different peculiarities, i.e., substantial and effective qualities. One must bear in mind that enzymes are catalytically active substances.

Keywords

Hydrolytic Enzyme Immune Complex Mesothelial Cell Label Enzyme Arthus Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Neuhold R (1974) Messung der enzymatischen Aktivität im Serum gesunder Versuchspersonen nach der oralen Verabreichung von Wobe-Mugos. Report of the Pathologisch-Mikrobiologisch Institut at the LandeskrankenhausGoogle Scholar
  2. 2.
    Stayr Steffen C, Menzel J (1985) Grandlagenuntersuchungen zur Enzymtherapie bei Immunkomplexen. Wien Klin Wochenschr 97 (8):376–385PubMedGoogle Scholar
  3. 3.
    Steffen C, Menzel J (1987) In-vivo-Abbau von Immunkomplexen in der Niere durch oral applizierte Enzyme. Wien Klin Wochenschr 99:525–531PubMedGoogle Scholar
  4. 4.
    Steffen C, Zeitholfer J, Menzel J, Smolen J (1979) Die antigen-induzierte experimentelle Arthritis als Prüfverfahren für Entzündungshemmung durch oral applizierte Substanzen. Rheumatologie 38:264Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • P. Streichhan
  • W. van Schaik
  • G. Stauder

There are no affiliations available

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