Abstract
The scientific rationale for the use of oral preparations of enzymes, such as Phlogenzyme (containing trypsin and bromelain), Mulsal-N (containing trypsin, bromelain, and papain), and Wobenzyme (containing trypsin, chymotrypsin, papain, and bromelain), for treatment of extra-gastrointestinal diseases in Man hinges critically upon the question of whether the enzymes (or a therapeutically significant amount of them) can be absorbed across the gastrointestinal tract in intact form. This is an area, formerly regarded as distinctly controversial, where opinion among gastrointestinal physiologists has changed markedly in the past two decades, and which is currently attracting renewed research activity on mechanisms of absorption. It is now accepted beyond reasonable doubt that significant (albeit small) amounts of many macromolecules can be absorbed in intact and biologically active form.
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Gardner, M.L.G. (1995). A Review of Current Knowledge of Gastrointestinal Absorption of Intact Proteins Including Medicinal Preparations of Proteolytic Enzymes. In: Absorption of Orally Administered Enzymes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79511-4_1
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DOI: https://doi.org/10.1007/978-3-642-79511-4_1
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