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Signal-transduction therapy

A novel approach to disease management

  • Chapter
EJB Reviews 1994

Part of the book series: EJB Reviews 1994 ((EJB REVIEWS,volume 1994))

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Abstract

In the past decade it has become apparent that many diseases result from aberrations in signaling pathways. These include proliferative diseases such as cancers, atherosclerosis and psoriasis and inflammatory conditions such as sepsis, rheumatoid arthritis and tissue rejection. These findings refocused the research of the medical community to seek new modalities for disease management which essentially consist of designing drugs which intercept cell signaling. In this review, the emerging success in using tyrosine kinase blockers and other signal interceptors, such as protein kinase C blockers, Ras blockers, Ca2+ signaling inhibitors and estrogen antagonists which inhibit growth of cancer cells in vitro and in vivo, will be discussed. These signal interceptors, especially tyrosine-kinase blockers, are also able to block inflammatory responses and the proliferation of vascular smooth muscle cells and psoriatic keratinocytes. The utility of signal interceptors in analyzing signal-transduction pathways is also discussed.

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Abbreviations

acyl2Gro:

diacyl glycerol

CAI:

carboxamide amino-imidazole

CTK:

cellular tyrosine kinase (s)

EGF:

epidermal growth factor

EGFR:

epidermal-growth-factor receptor

FKBP:

FK506-binding protein

InsP 3 :

inositol trisphosphate

KDR:

kinase insert domain-containing receptor

MAP:

microtubule-associated protein

MAPK:

microtubule-associated protein kinase

MAPKK:

microtubule-associated protein kinase kinase

PDGF:

platelet-derived growth factor

PDGFR:

platelet-derived growth factor receptor

PKC:

protein kinase C

PLC:

phospholipase C

PTK:

protein-tyrosine kinase (s)

RTK:

receptor tyrosine kinase(s)

TGF:

transforming growth factor

VEGF:

vascular endothelial growth factor

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  1. Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, IS-91904, Israel

    Alexander Levitzki

  2. SUGEN, Inc., Redwood City, California, USA

    Alexander Levitzki

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Levitzki, A. (1994). Signal-transduction therapy. In: EJB Reviews 1994. EJB Reviews 1994, vol 1994. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79502-2_15

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  • DOI: https://doi.org/10.1007/978-3-642-79502-2_15

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