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Developmentally regulated expression of linker-histone variants in vertebrates

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EJB Reviews 1994

Part of the book series: EJB Reviews 1994 ((EJB REVIEWS,volume 1994))

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Abstract

The identification of histone H1 variants in vertebrates suggests that these proteins may have specialized functions. During embryonic development, a correspondence between the expression of each of the linker-histone variants and the proliferative and transcriptional activity of embryonic cells can be observed. Analysis of the developmentally regulated expression of these variants leads to the subdivision of these variants into distinct classes. This subdivision may also provide insight into the significance of the differential expression of variants and the roles individual linker histones have in chromatin structure and function.

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Authors and Affiliations

  1. Laboratoire de Biologie Moléculaire du Cycle Cellulaire, INSERM U309, CEA/DBMS/CEN-G, Grenoble, France

    Saadi Khochbin

  2. DBMS/BMCC CEN-G, 17 rue des Martyrs, F-38054, Grenoble, Cedex 9, France

    Saadi Khochbin

  3. Laboratory of Molecular Embryology, National Institute of Child Health and Human Development, NIH, Bldg. 6, Rm. B1A-13, Bethesda, USA

    Alan P. Wolffe

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Khochbin, S., Wolffe, A.P. (1994). Developmentally regulated expression of linker-histone variants in vertebrates. In: EJB Reviews 1994. EJB Reviews 1994, vol 1994. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79502-2_14

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  • DOI: https://doi.org/10.1007/978-3-642-79502-2_14

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