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UBF, an Architectural Element for RNA Polymerase I Promoters

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Nucleic Acids and Molecular Biology

Part of the book series: Nucleic Acids and Molecular Biology ((NUCLEIC,volume 9))

Abstract

Activation of transcription by RNA polymerase I (polI) requires that an assembly of protein factors locate the polI promoter and form a stable preinitiation complex. It is apparently this pre-initiation complex, not the underlying DNA sequence, which is then recognized by polI as it cycles through many rounds of RNA chain initiation, elongation, and termination. In vertebrate cells two components have so far been identified as having roles in forming the polI pre-initiation complex. One is SL1, a complex of four polypeptides one of which is the TATA-binding protein.4 The other is UBF, the subject of this chapter.

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Author information

Authors and Affiliations

  1. Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle, WA, 98104, USA

    R. H. Reeder

  2. Biology Department, Washington University, Campus Box 1137, One Brookings Drive, St. Louis, MO, 63130, USA

    C. S. Pikaard

  3. Biomedical Research Center, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, UK

    B. McStay

Authors
  1. R. H. Reeder
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  2. C. S. Pikaard
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  3. B. McStay
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Editor information

Editors and Affiliations

  1. Max-Planck-Institut für Experimentelle Medizin, Hermann-Rein-Straße 3, 37075, Göttingen, Germany

    Fritz Eckstein

  2. Biochemistry Department, University of Dundee, Dundee, DD1 4HN, UK

    David M. J. Lilley

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© 1995 Springer-Verlag Berlin Heidelberg

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Reeder, R.H., Pikaard, C.S., McStay, B. (1995). UBF, an Architectural Element for RNA Polymerase I Promoters. In: Eckstein, F., Lilley, D.M.J. (eds) Nucleic Acids and Molecular Biology. Nucleic Acids and Molecular Biology, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79488-9_12

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  • DOI: https://doi.org/10.1007/978-3-642-79488-9_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79490-2

  • Online ISBN: 978-3-642-79488-9

  • eBook Packages: Springer Book Archive

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