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Operative Dermatologie pp 177–186Cite as

Das Dermatofibrosarcoma protuberans (DFSP). Schwierigkeiten in Diagnostik und Möglichkeiten der Therapie

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Part of the book series: Fortschritte der operativen und onkologischen Dermatologie ((OP.DERMATOLOGIE,volume 9))

Zusammenfassung

Das Dermatofibrosarcoma protuberans (DFSP) ist ein Tumor intermediärer Dignität. Er zeichnet sich durch lokal infiltrativ-destruktives Wachstum, hohe Rezidivneigung und geringe Me-tastasierungstendenz aus. Die Ätiologie des Tumors ist nicht bekannt. Er gehört zur Gruppe der fibrohistiozytären Tumoren; neuere Untersuchungen leiten die Histogenese von den erstmals von Nickoloff beschriebenen CD 34-positiven Spindelzellen der Haut ab. Die histologi-sche Differentialdiagnose hat neben den eigentlichen fibrohistiozytären Tumoren auch spin-delzellige Tumoren anderer Ursprungsgewebe und reaktive Veränderungen zu berücksichtigen. Neue diagnostische Möglichkeiten ergeben sich mit der Verwendung des anti-CD 34-Antikörpers. Die chirurgische Therapie in Form einer großzügigen Exzision unter Mitnahme der subtumoralen Muskelfaszie stellt die einzige effektive Therapiemethode dar.

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  1. A. Petres
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  2. S. Wiemers
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  3. W. Vanscheidt
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  4. E. Schopf
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  1. Abt. Dermatochirurgie, Universitätsklinikum der Medizinischen Fakultät, der Humboldt-Universität Berlin, Schumannstraße 20-21, D-10117, Berlin, Deutschland

    Helmut Winter  & K.-P. Bellmann  & 

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Petres, A., Wiemers, S., Vanscheidt, W., Schopf, E. (1995). Das Dermatofibrosarcoma protuberans (DFSP). Schwierigkeiten in Diagnostik und Möglichkeiten der Therapie. In: Winter, H., Bellmann, KP. (eds) Operative Dermatologie. Fortschritte der operativen und onkologischen Dermatologie, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79468-1_32

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  • DOI: https://doi.org/10.1007/978-3-642-79468-1_32

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