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The SCID (Severe Combined Immunodeficiency) Mouse — Its Biology and Use in Immunotoxicological Research

  • Martinus Løvik
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 17)

Abstract

In medical research, there is a need to bridge the gap between in vivo animal experimentation and studies on human cells and tissues in vitro. Two clefts have to be bridged — one is the species difference, the other is the in vivo — in vitro difference. The SCID mouse reconstituted with human cells may represent an important tool for building the bridges needed. Models based on reconstituted SCID mice make experimentation with human cells in an in vivo situation possible without the ethical and practical constraints that limit studies in man.

Keywords

Scid Mouse Human Peripheral Blood Human Peripheral Blood Mononuclear Cell Severe Combine Immunodeficiency Human Peripheral Blood Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Martinus Løvik
    • 1
  1. 1.Section for Environmental Immunology, Department of Environmental MedicineNational Institute of Public HealthOsloNorway

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