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Ex Vivo and in Vitro Models in Acetaminophen Hepatotoxicity Studies. Relationship between Glutathione Depletion, Oxidative Stress and Disturbances in Calcium Homeostasis and Energy Metabolism

  • S. Ellouk-Achard
  • V. Levresse
  • C. Martin
  • C. Pham-Huy
  • H. Dutertre-Catella
  • M. Thevenin
  • J.-M. Warnet
  • J. R. Claude
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 17)

Abstract

The hepatotoxicity of acetaminophen (APAP) seems to be linked to several biochemical perturbations such as glutathione depletion, oxidative stress, Ca2+ homeostasis disturbances and/or changes in energy metabolism.

Keywords

Glutathione Reductase Glutathione Depletion Glutathione Reductase Activity GSSG Content GSSG Ratio 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • S. Ellouk-Achard
    • 1
  • V. Levresse
    • 1
  • C. Martin
    • 1
  • C. Pham-Huy
    • 1
  • H. Dutertre-Catella
    • 1
  • M. Thevenin
    • 1
  • J.-M. Warnet
    • 1
  • J. R. Claude
    • 1
  1. 1.Paris V, Faculté de Pharmacie, Laboratoire de Toxicologie, EA 207Université René-DescartesParis Cedex 06France

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