Ex Vivo and in Vitro Models in Acetaminophen Hepatotoxicity Studies. Relationship between Glutathione Depletion, Oxidative Stress and Disturbances in Calcium Homeostasis and Energy Metabolism
The hepatotoxicity of acetaminophen (APAP) seems to be linked to several biochemical perturbations such as glutathione depletion, oxidative stress, Ca2+ homeostasis disturbances and/or changes in energy metabolism.
KeywordsGlutathione Reductase Glutathione Depletion Glutathione Reductase Activity GSSG Content GSSG Ratio
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- Omura T and Sato R (1964) The carbon monoxide binding pigment of liver microsomes. Evidence for its hemoprotein nature. J Biol Chem 239: 393–399Google Scholar
- Pham-Huy C, Martin C, Thevenin M, Warnet JM, Ellouk-Achard S, Massicot F, Dutertre-Catella H and Claude JR (1993) Determination of ATP, ADP, AMP and other nucleotides in tissues and cell cultures by HPLC. Pharmacol Toxicol 73: 120Google Scholar