FcεRI: Structure, Cellular Distribution, and Function
Type I allergic reactions, such as allergic rhinoconjunctivitis, allergic asthma and anaphylactic urticaria, are characterized by elevated levels of serum IgE including allergen-specific IgE. In their monomeric form, these IgE molecules are capable of binding to the high affinity receptor for IgE (FcεRI) on mast cells and basophils. This receptor is one of the key molecules in triggering classical type I allergic reactions (reviewed in ; Fig. 1). The binding of IgE to FcsRI by itself does not induce any apparent cell activation. In sensitized individuals, however, the interaction of multivalent allergens with receptor-bound IgE induces the redistribution of IgE-receptor complexes on the cell surface, which in turn triggers cellular degranulation and the release of factors responsible for the elicitation of allergic symptoms.
KeywordsManifold Tyrosine Leukemia Serotonin Polypeptide
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