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FcεRI: Structure, Cellular Distribution, and Function

  • D. Maurer
  • E. Fiebiger
  • B. Reininger
  • G. Stingl
Conference paper

Abstract

Type I allergic reactions, such as allergic rhinoconjunctivitis, allergic asthma and anaphylactic urticaria, are characterized by elevated levels of serum IgE including allergen-specific IgE. In their monomeric form, these IgE molecules are capable of binding to the high affinity receptor for IgE (FcεRI) on mast cells and basophils. This receptor is one of the key molecules in triggering classical type I allergic reactions (reviewed in [1]; Fig. 1). The binding of IgE to FcsRI by itself does not induce any apparent cell activation. In sensitized individuals, however, the interaction of multivalent allergens with receptor-bound IgE induces the redistribution of IgE-receptor complexes on the cell surface, which in turn triggers cellular degranulation and the release of factors responsible for the elicitation of allergic symptoms.

Keywords

Mast Cell Atopic Dermatitis Allergic Rhinoconjunctivitis Atopic Person FCeRI Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Kinet J-P (1990) The high affinity receptor for IgE. Curr Opin Immunol 2: 499–505CrossRefGoogle Scholar
  2. 2.
    Metzger H, Kinet J-P, Perez-Montfort R, Rivnay B, Wank SA (1983) A tetrameric model for the structure of the mast cell receptor with high affinity for IgE. In: Yamamura Y, Tada T (eds) Progress in immunology, vol 5. Academic Press, Orlando, p 493Google Scholar
  3. 3.
    Metzger H, Alcaraz G, Hohman R, Kinet J-P, Pribluda V, Quarto R (1986) The receptor with high affinity for immunoglobulin IgE. Annu Rev Immunol 4: 419–470PubMedCrossRefGoogle Scholar
  4. 4.
    Hakimi J, Seals C, Kondas JA, Pettine L, Danho W, Kochan J (1990) The alpha subunit of the human IgE receptor (FcaRI) is sufficient for high affinity IgE binding. J Biol Chem 256: 22079–22081Google Scholar
  5. 5.
    Miller L, Alber G, Varin-Blank N, Ludowyke R, Metzger H (1990) Trans-membrane signalling in P815 mastocytoma cells by transfected IgE receptors. J Biol Chem 256: 12444–12452Google Scholar
  6. 6.
    Alber G, Miller L, Jelsema C, Varin-Blank N, Metzger H (1991) Structure/ function relationships of the mast cell high-affinity receptor for IgE (FceRI). J Biol Chem 266: 22613–22620PubMedGoogle Scholar
  7. 7.
    Miller L, Blank U, Metzger H, Kinet J-P (1989) Expression of high-affinity binding of human immunoglobulin E by transfected cells. Science 244: 334PubMedCrossRefGoogle Scholar
  8. 8.
    Orloff DG, Ra C, Frank SJ, Klausner RD, Kinet J-P (1990) Family of disulfidlinked dimers containing the zeta and eta chains of the T-cell receptor and the gamma chain of Fc receptors. Nature 347: 189–191PubMedCrossRefGoogle Scholar
  9. 9.
    Irving BA, Weiss A (1991) The cytoplasmic domain of the T cell receptor Ç chain is sufficient to couple to receptor associated signal transduction pathways. Cell 64: 891–901PubMedCrossRefGoogle Scholar
  10. 10.
    Jouvin MHE, Adamczewski M, Numerof R, Letourneur O, Valle A, Kinet JP (1994) Differential control of the tyrosine kinases lyn and syk by the two signaling chains of the high affinity immunoglobulin E receptor. J Biol Chem 269: 5918–5925PubMedGoogle Scholar
  11. 11.
    Mao SY, Alber G, Rivera J, Kochan J, Metzger H (1992) Interaction of aggregated native and mutant IgE receptors with the cytoskeleton. Proc Natl Acad Sci U S A 89: 222–226PubMedCrossRefGoogle Scholar
  12. 12.
    Beaven MA, Moore JP, Smith GA, Hasketh TR, Metcalfe JC (1984) The calcium signal and phosphatidylinositol breakdown in 2H4 cells. J Biol Chem 259: 7137–7142PubMedGoogle Scholar
  13. 13.
    Mohr FC, Fewtrell C (1987) The relative contribution of extracellular and intracellular calcium to secretion from tumor mast cells. J Biol Chem 262: 10638–10643PubMedGoogle Scholar
  14. 14.
    White KN, Metzger H (1988) Translocation of protein kinase C in rat basophilic leukemia cells induced by phorbol ester or by aggregation of IgE receptors. J Immunol 143: 942–947Google Scholar
  15. 15.
    Plaut M, Pierce JH, Watson CJ, Hanley-Hyde J, Nordan RP, Paul WE (1989) Mast cell lines produce lymphokines in response to cross-linkage of FcERI or to calcium ionophor. Nature 339: 64–67PubMedCrossRefGoogle Scholar
  16. 16.
    Wodnar-Filipovicz A, Heusser CH, Moroni C (1989) Production of the hemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation. Nature 339: 150–152CrossRefGoogle Scholar
  17. 17.
    Burd RP, Rogers HW, Gordon JR, Martin CA, Jayaraman S, Wilson SD, Dvorak AM, Galli SJ, Dorf ME (1989) Interleukin-3 dependent and independent mast cells stimulated with IgE and antigen express multiple cytokines. J Exp Med 170: 245–257PubMedCrossRefGoogle Scholar
  18. 18.
    Brynzeel-Koomen C, Wichen van DF, Toonstra J, Berrens L, Brynzeel PL (1986) The presence of IgE molecules on epidermal Langerhans cells in patients with atopic dermatitis. Arch Dermatol Res 278: 199–204CrossRefGoogle Scholar
  19. 19.
    Wang B, Rieger A, Kilgus O, Ochiai K, Maurer D, Födinger D, Kinet J-P, Stingl G (1992) Epidermal Langerhans cells from normal human skin bind monomeric IgE via FcERI. J Exp Med 175: 1353–1365PubMedCrossRefGoogle Scholar
  20. 20.
    Bieber T, de la Salle H, Wollenberg A, Hakimi J, Chizzonite R, Ring J, Hanau D, de le Salle C (1992) Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (FcERI). J Exp Med 175: 1285–1290PubMedCrossRefGoogle Scholar
  21. 21.
    Maurer D, Fiebiger E, Reininger B, Wolff-Winiski B, Jouvin M-H, Kilgus O, Kinet J-P, Stingl G (1994) Expression of functional high affinity IgE receptors (FcERI) on monocytes of atopic individuals. J Exp Med 179: 745–750PubMedCrossRefGoogle Scholar
  22. 22.
    Gounni AS, Lamkhioued B, Ochiai K, Tanaka Y, Delaporte E, Capron A, Kinet J-P, Capron M (1994) High affinity IgE receptor on eosinophils is involved in defense against parasites. Nature 367: 183–186PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • D. Maurer
  • E. Fiebiger
  • B. Reininger
  • G. Stingl

There are no affiliations available

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