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The Central Role of T Cells in IgE Regulation and Bronchial Hyperreactivity — A Target for Specific Immunomodulation

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Symposium in Immunology IV

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Abstract

Bronchial asthma (BA) represents the manifestation of allergic diseases on the airways and the lung. The disease is characterized by a certain type of airway mucosa inflammation and the presence of a state of increased airways responsiveness (AR). AR is defined as an abnormal response of airway smooth muscle cells to a variety of stimuli including allergens, air pollutants and pharmacological agents such as histamine and metacholine [1, 2]. Local exposure to these stimuli causes narrowing of the airways at a dose and concentration range which usually is uneffective in nonasthmatic subjects. The results from numerous family studies indicate that genetic factors contribute to the development of BA.

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Authors
  1. H. Renz
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  2. E. W. Gelfand
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Editor information

Editors and Affiliations

  1. Institut für Immunologie, Universität Wien, Borschkegasse 8a, 1090, Wien, Austria

    Martha M. Eibl

  2. Department of Hematology, Johannes Gutenberg Universität, Langenbeckstr. 1, 55131, Mainz, Germany

    Christoph Huber

  3. Abteilung für Rheumatologie und Klinische Immunologie, Medizinische Universitätsklinik, Hugstetter Str. 55, 79106, Freiburg, Germany

    Hans H. Peter

  4. Pädiatrische Pneumologie und Immunologie, Universitäts-Klinikum Rudolf Virchow, Standort Charlottenburg, Heubnerweg 6, 14059, Berlin, Germany

    Ulrich Wahn

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© 1995 Springer-Verlag Berlin Heidelberg

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Renz, H., Gelfand, E.W. (1995). The Central Role of T Cells in IgE Regulation and Bronchial Hyperreactivity — A Target for Specific Immunomodulation. In: Eibl, M.M., Huber, C., Peter, H.H., Wahn, U. (eds) Symposium in Immunology IV. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79446-9_3

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  • DOI: https://doi.org/10.1007/978-3-642-79446-9_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58769-9

  • Online ISBN: 978-3-642-79446-9

  • eBook Packages: Springer Book Archive

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