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Characterization of Signals Leading to Clonal Expansion or to Cell Death During Lymphocyte B Cell Activation

  • Chapter
Book cover Apoptosis in Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 200))

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Abstract

The immune system is endowed with a multitude of different mechanisms to eliminate, paralyze or neutralize T and B lymphocytes expressing self-reactive antigen receptors that might endanger the individual’s life. The ability of both types of lymphocytes to recognize and react to different stimuli is a learning process that occurs during lymphocyte differentiation, and the mechanisms implicated in self-tolerance intervene at determined control points following developmental criteria. B and T lymphocyte differentiation from committed precursor cells into antibody-secreting plasma cells or effector T cells proceeds through multiple steps that are defined by changes in the expression pattern of lineage-specific genes (Moller 1994).

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Authors and Affiliations

  1. Instituto de Bioquimica, CSIC, Universidad Complutense, 28040, Madrid, Spain

    L. Bosca & S. Hortelano

  2. Centro Nacional de Biolecnologia CSIC, Universidad Autonoma, Campus de Cantoblanco, 28049, Madrid, Spain

    C. Stauber, E. Baixeras & C. Martinez-A.

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  1. L. Bosca
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  2. C. Stauber
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  3. S. Hortelano
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  4. E. Baixeras
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  5. C. Martinez-A.
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  1. Génétique Moléculaire et Biologie du Développment, CNRS-UPR 420, 19, rue Guy Môquet, BP8, 94801, Villejuif Cedex, France

    Guido Kroemer

  2. Centro Nacional de Biotecnologia CSIC Campus de Cantoblanco, Universidad Autonoma, 28049, Madrid, Spain

    Carlos Martinez-A.

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© 1995 Springer-Verlag Berlin Heidelberg

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Bosca, L., Stauber, C., Hortelano, S., Baixeras, E., Martinez-A., C. (1995). Characterization of Signals Leading to Clonal Expansion or to Cell Death During Lymphocyte B Cell Activation. In: Kroemer, G., Martinez-A., C. (eds) Apoptosis in Immunology. Current Topics in Microbiology and Immunology, vol 200. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79437-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-79437-7_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79439-1

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