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B Cell Activation and Apoptosis

  • Chapter
Apoptosis in Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 200))

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Abstract

The antigen recognition potential of lymphocytes is theoretically so vast that, without appropriate regulation, the immune system should inevitably react to self-antigens. The development of B and T lymphocytes is therefore controlled at multiple levels in order to ensure that individuals will be able to respond to a large array of foreign antigens while being tolerant to self. Under some circumstances, the encounter between a foreign antigen and a naive lymphocyte will result in the emergence of a clonal population of effector cells able to eliminate this antigen. Such activation-induced positive selection not only involves the antigen-dependent step, but also depends on the differentiation state of the cell, and often requires additional stimuli from the environment. By contrast, activation-induced negative selection of lymphocytes refers essentially to the process whereby the immune system eliminates potentially harmful self-reactive lymphocytes. Again, the state of differentiation of lymphocytes and/or environmental signals play a critical role in this self-tolerance process. Viewed in this way, the distinction between activation-induced positive and negative selection is not straightforward. However, studies conducted recently had shed new light on this area and contribute to a better understanding of the underlying processes which keep the immune system under control.

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Authors and Affiliations

  1. Unité d’Immunochimie Analytique, Institut Pasteur, 25 rue du Docteur Roux, 75724, Paris Cedex 15, France

    P. Sarthou, L. Benhamou & P.-A. Cazenave

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  1. P. Sarthou
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  2. L. Benhamou
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  3. P.-A. Cazenave
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  1. Génétique Moléculaire et Biologie du Développment, CNRS-UPR 420, 19, rue Guy Môquet, BP8, 94801, Villejuif Cedex, France

    Guido Kroemer

  2. Centro Nacional de Biotecnologia CSIC Campus de Cantoblanco, Universidad Autonoma, 28049, Madrid, Spain

    Carlos Martinez-A.

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Sarthou, P., Benhamou, L., Cazenave, PA. (1995). B Cell Activation and Apoptosis. In: Kroemer, G., Martinez-A., C. (eds) Apoptosis in Immunology. Current Topics in Microbiology and Immunology, vol 200. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79437-7_2

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  • DOI: https://doi.org/10.1007/978-3-642-79437-7_2

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