Differential diagnosis of intracranial tumours using in vitro magnetic resonance spectroscopy
The diagnostic utility of magnetic resonance spectroscopy (MRS) in intracranial tumours was investigated using in vitro high-resolution spectra. We examined 59 surgically excised samples of brain tumours and 4 nonneoplastic lobectomised brains. Glioblastoma can be distinguished from metastatic brain tumour by the total creatine and glycine peak, medulloblastoma from ependymoma by the taurine peak and neurinoma from meningioma by the inositol peak on 1H-MRS. The phosphomonoester peak may be useful in distinguishing pituitary adenoma, malignant lymphoma and meduloblastoma from other tumours by 31P-MRS. MRS may provide additional information when the differential diagnosis of tumours by MRI is difficult.
key wordsMagnetic resonance spectroscopy Glycine Inositol Phosphorylethnolamine
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