Differential diagnosis of intracranial tumours using in vitro magnetic resonance spectroscopy

  • Y. Kinoshita
  • A. Yokota
  • Y. Koga
Conference paper

Abstract

The diagnostic utility of magnetic resonance spectroscopy (MRS) in intracranial tumours was investigated using in vitro high-resolution spectra. We examined 59 surgically excised samples of brain tumours and 4 nonneoplastic lobectomised brains. Glioblastoma can be distinguished from metastatic brain tumour by the total creatine and glycine peak, medulloblastoma from ependymoma by the taurine peak and neurinoma from meningioma by the inositol peak on 1H-MRS. The phosphomonoester peak may be useful in distinguishing pituitary adenoma, malignant lymphoma and meduloblastoma from other tumours by 31P-MRS. MRS may provide additional information when the differential diagnosis of tumours by MRI is difficult.

key words

Magnetic resonance spectroscopy Glycine Inositol Phosphorylethnolamine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Petroff OAC, Ogino T, Alger JR (1988) High-resolution proton magnetic resonance spectroscopy of rabbit brain: regional metabolite levels and postmortem changes. J Neurochem 51: 163–171.PubMedCrossRefGoogle Scholar
  2. 2.
    Kinoshita Y, Kajiwara H, Yokota A, Koga Y (1992) Protonmagnetic resonance spectroscopy of astrocytic tumors: an in vitro study. Neurol Chir (Tokyo) 33: 350–359.CrossRefGoogle Scholar
  3. 3.
    Kinoshita Y, Kajiwara H, Yokota A, Koga Y (in press) Proton magnetic resonance spectroscopy of brain tumors: an in vitro study. Neurosurgery.Google Scholar
  4. 4.
    Kinoshita Y, Yokota A, Koga Y (in press) Phosphorylethanolamine content in human brain tumors. Neurol Med Chir.Google Scholar
  5. 5.
    Gyulai L, Bolinger L, Leigh JS, Barlow C, Chance B (1984) Phosphorylethanolamine — the major constituent of the phosphomonoester peak observed by 5lP-NMR on developing dog brain. FEBS Lett 178: 137–142.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Y. Kinoshita
    • 1
  • A. Yokota
    • 1
  • Y. Koga
    • 2
  1. 1.Department of NeurosurgeryUniversity of Occupational and Environmental HealthKitakyushuJapan
  2. 2.ChemistryUniversity of Occupational and Environmental HealthKitakyushuJapan

Personalised recommendations