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Gadolinium-DTPA-enhanced MRI in transient cerebral ischaemia: experimental study

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Proceedings of the XV Symposium Neuroradiologicum

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Abstract

The influence of transient ischaemia on cerebrovascular permeability was studied sequentially in rats by magnetic resonance imaging with contrast enhancement using gadolinium-DTPA. Unilateral intraluminal occlusion of the internal carotid and middle cerebral arteries, lasting from 5 min to 5 h, was performed. Parenchymal enhancement of the striatum and the cerebral cortex on the ischaemic side, due to disruption of the blood-brain barrier, was seen in rats subjected to 1–5 h of ischaemia; it was detected earlier in rats subjected to longer periods of ischaemia. Enhancement of the lateral ventricle due to disruption of the blood-cerebrospinal fluid barrier at the choroid plexus and enhancement of the ipsilateral anterior cerebral artery appeared transiently in the early reperfusion stage (6 h and 1 day) in rats subjected to 15 min–5 h of ischaemia.

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References

  1. Koizumi J, Yoshida Y, Nakazawa T, Ooneda G (1986) Experimental studies of ischaemic brain oedema. Jpn J Stroke 8: 1–7.

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  2. Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20: 84–91.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, Kumamoto University Medical School, Kumamoto, Japan

    S. Nagahiro & Y. Ushio

  2. Department of Radiology, Kumamoto University Medical School, Kumamoto, Japan

    M. Sumi & M. Takahashi

Authors
  1. S. Nagahiro
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  2. Y. Ushio
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  3. M. Sumi
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  4. M. Takahashi
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Editor information

Editors and Affiliations

  1. Department of Radiology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860, Japan

    Mutsumasa Takahashi (Chairmann) & Yukunori Korogi (Assistant Professor) (Chairmann) &  (Assistant Professor)

  2. Lysholm Department of Radiology, National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK

    Ivan Moseley (Director) (Director)

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© 1995 Springer-Verlag Berlin Heidelberg

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Nagahiro, S., Ushio, Y., Sumi, M., Takahashi, M. (1995). Gadolinium-DTPA-enhanced MRI in transient cerebral ischaemia: experimental study. In: Takahashi, M., Korogi, Y., Moseley, I. (eds) Proceedings of the XV Symposium Neuroradiologicum. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79434-6_46

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  • DOI: https://doi.org/10.1007/978-3-642-79434-6_46

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79436-0

  • Online ISBN: 978-3-642-79434-6

  • eBook Packages: Springer Book Archive

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