Abstract
When lesions are detected on magnetic resonance images (MRI) of the brain stem, it can be difficult to determine exactly which nuclei or fibre tracts are involved. We introduce a user-friendly automatic algorithm that calculates a nonlinear transformation that matches a given anatomical atlas to MR images. A brain stem atlas was constructed from histological serial sections of a human brain stem, in which the auditory nuclei and fibre tracts were traced. The algorithm is based on matching the brain stem outline of MRI sections to the corresponding atlas sections. The estimated transformations are applied to the nuclei and fibre tracts in the atlas and are then superimposed on the MR images. The algorithm was tested on MRI patients with multiple sclerosis (MS) whose ability to judge the laterality of sounds was tested psychoacoustically. Our results indicate that there is a relationship between the type of behavioural abnormality and the location of MS lesions relative to the auditory pathway.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Rumbach L, Armsprach JP, Gounot D, Namer IJ, Chambron J, Warter JM, Collard M (1991) Nuclear magnetic resonance T2 relaxation times in multiple sclerosis. J Neurol Sci 104: 176–181.
Furst M, Levine RA, Korczyn AD, Fullerton BC, Tadmor R, Algom D (1994) Brainstem lesions and click lateralization in patients with multiple sclerosis. Hear Res (in press)
Levine RA, Gardner JC, Stufflebeam SM, Fullerton BC, Carisle EW, Furst M, Rosen BR, Kiang NYS (1993) Binaural auditory processing in multiple sclerosis patients. Hear Res 68: 59–72.
Gonzales RC, Woods RE (1992) Digital image processing. Addison-Wesley, Reading, Mass.
Tenny R (1994) Algorithm for matching brainstem atlas to MR images. M.Sc Thesis, Faculty of Engineering, Tel Aviv University.
Bookstein F (1978) The measurement of biological shape and shape change (Lecture Notes in Biomathematics). Springer-Verlag, New York.
Levine RA, Gardner JC, Stufflebeam SM, Fullerton BC, Carisle EW, Furst M, Rosen BR, Kiang NYS (1993) Effects of multiple sclerosis brainstem lesions on sound lateralization and brainstem auditory evoked potentials. Hear Res 68:73–88.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Tadmor, R., Tenny, R., Furst, M. (1995). Algorithm for automatic matching of brain stem atlas to MR images. In: Takahashi, M., Korogi, Y., Moseley, I. (eds) Proceedings of the XV Symposium Neuroradiologicum. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79434-6_16
Download citation
DOI: https://doi.org/10.1007/978-3-642-79434-6_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-79436-0
Online ISBN: 978-3-642-79434-6
eBook Packages: Springer Book Archive