Neuroradiology of Pelizaeus-Merzbacher disease: a long-term follow-up study

  • A. Bozzao
  • M. Gallucci
  • F. Cardona
  • R. Manetta
  • E. Bielli
  • F. Navarra
Conference paper

Abstract

Pelizaeus-Merzbacher disease (PMD) is a leuko-dystrophy linked to an arrest of myelin formation of unknown aetiology. We report a longitudinal study (1–6 years) of seven affected patients. In all patients, MRI showed diffuse alteration of the supratentorial white matter. The infratentorial white matter was involved in the conatal form as well. Intermediate appearences were seen in the classical and non-X-linked forms. Except for the conatal case, little or no neuroradiological progression was seen in contrast with the slow progressive clinical worsening.

key words

Palizaeus-Merzbacher disease Magnetic resonance imaging Follow-up 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • A. Bozzao
    • 1
  • M. Gallucci
    • 1
  • F. Cardona
    • 2
  • R. Manetta
    • 1
  • E. Bielli
    • 1
  • F. Navarra
    • 1
  1. 1.Department of RadiologyUniversity of L’AquilaL’AquilaItaly
  2. 2.Department of Child NeurologyUniversity of Rome “La Sapienza”RomeItaly

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