Skip to main content
SpringerLink
Log in

Non-Hodgkin-Lymphome

  • Chapter
Book cover Strahlentherapie

  • 162 Accesses

Zusammenfassung

Maligne Lymphome sind Neoplasien der Lymph-knoten und anderer lymphatischer Gewebe wie Milz, Thymus und Waldeyer-Rachenring. Die Non-Hodgkin-Lymphome (NHL) sind eine seltene Tumorerkrankung. Die Angaben zur Inzidenz für die Gesamtheit der nodalen und extranodalen NHL schwanken zwischen 8 und 12 Neuerkrankungen auf 100 000 Einwohner pro Jahr (Otter et al. 1989 b). Die jährliche Erkrankungshäufigkeit in Deutschland beträgt für alle malignen Lymphome etwa 6/100 000/Jahr. Der Altersgipfel für NHL vom niedrigen Malignitätsgrad liegt im 6. –7. Lebensjahrzehnt; sie kommen in der Altersgruppe unter 25 Jahren sehr selten und unter dem 18. Lebensjahr praktisch nie vor. Für alle Lymphome vom hohen Malignitätsgrad gilt, daß sie in allen Altersgruppen vorkommen, mit einem Gipfel in den ersten beiden Lebensjahrzehnten und im höheren Lebensalter (Lennert u. Feller 1992). Männer werden bei allen NHL häufiger betroffen als Frauen (1,7:1). Das Burkitt-Lymphom kommt in Zentralafrika und Neuguinea endemisch vor, während es im übrigen nur sporadisch beobachtet wird. Die Erkrankungshäufigkeit scheint insgesamt zuzunehmen, die Gründe hierfür sind noch unklar.

Das Kapitel baut wesentlich auf dem Beitrag von Professor K. Musshoff in der 3. Auflage dieses Buches auf und ist ihm gewidmet.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 149.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Amendola BE, McClatchey KD, Amendola BA et al. (1986) Primary large-cell lymphoma of the central nervous system. Am J Clin Oncol 9: 204–208

    PubMed  CAS  Google Scholar 

  • Anger M, Allan N (1990) Primary ileocecal lymphoma. Cancer 55: 358–362

    Google Scholar 

  • Armitage J (1993) Treatment of non-Hodgkin’s lymphoma. N Engl J Med 328: 1023–1030

    PubMed  CAS  Google Scholar 

  • Azab M, Henry-Amar M, Rougier P et al. (1989) Prognostic factors in primary gastrointestinal non-Hodgkin’s lymphoma–a multivariate analysis, report of 106 cases and review of the literature. Cancer 64: 1208–1217

    PubMed  CAS  Google Scholar 

  • Bacci G, Ferraro A, Casadei R et al. (1991) Primary lymphoma of bone: Long term results in patients treated with vincristine - adriamycin - cyclophosphamide and local irradiation. J Chemother 3: 189–193

    PubMed  CAS  Google Scholar 

  • Bairey O, Kremer I, Rakowsky E et al. (1994) Orbital and adnexal involvement in systemic non-Hodgkin’s lymphoma. Cancer 73: 2395–2399

    PubMed  CAS  Google Scholar 

  • Bajetta E, Valagussa P, Bonadonna G et al. (1988) Combined modality treatment for stage I-II non-Hodgkin’s lymphomas: CVP versus BACOP chemotherapy. Int J Radiat Oncol Biol Phys 15: 3–12

    PubMed  CAS  Google Scholar 

  • Balzereit A (1995) Primäre Strahlentherapie der Non-Hodgkin-Lymphome vom zentroblastisch-zentrozytischen Typ der klinischen Stadien I-III. Med. Diss, Universität Essen

    Google Scholar 

  • Bamberg M (1987) Mycosis fungoides. In: Scherer E (Hrsg) Strahlentherapie, 3. Aufl. Springer, Berlin Heidelberg New York Tokyo, S 387–411

    Google Scholar 

  • Benett MH, Millet YL (1969) Nodular sclerotic lymphosarcoma. A possible new clinicopathological entity. Clin Radiol 20: 339–343

    Google Scholar 

  • Bessell E, Henk J, Wright J, Whitelocke R (1988) Orbital and conjunctival lymphoma: treatment and prognosis. Radiother Oncol 13: 237–244

    PubMed  CAS  Google Scholar 

  • Blair TJ, Evans RG, Buskirk GJ et al. (1985) Radiotherapeutic management of primary thyroid lymphoma. Int J Radiat Oncol Biol Phys 11: 365

    PubMed  CAS  Google Scholar 

  • Brada M, Dearnaley D, Horwich A, Bloom HJG (1990) Management of primary cerebral lymphoma with initial chemotherapy. Preliminary results and comparison with patients treated with radiotherapy alone. Int J Radiat Oncol Biol Phys 18: 787–792

    PubMed  CAS  Google Scholar 

  • Brill NE, Baehr G, Rosenthal N (1925) Generalized giant lymphfollicle hyperplasia lymph-nodes and spleen. A hitherto undescribed type. J Am Med Ass 84: 668

    Google Scholar 

  • Brittinger G, Bartels H, Common H et al. (1983) Klinik, Prognose und internistische Therapie der Non-Hodgkin-Lymphome vom hohen Malignitätsgrad. Verh Dtsch Ges Inn Med 89: 337–352

    Google Scholar 

  • Brittinger G, Bartels H, Common H et al. (1984) Clinical and prognostic relevance of the Kiel classification of non-Hodgkin’s lymphomas. Results of a prospective multicenter study by the Kiel lymphoma study group. Hematol Oncol 2: 269–306

    PubMed  CAS  Google Scholar 

  • Brittinger G, Meusers P, Musshoff K (1985) Non-HodgkinLymphome und Plasmozytom (Multiples Myelom). In: Gross R, Schmidt CG (Hrsg) Klinische Onkologie. Thieme, Stuttgart

    Google Scholar 

  • Brittinger H, Gyenes T (1984) Stadiendiagnostik der NonHodgkin-Lymphome. In: Diehl V, Sack H (Hrsg) Diagnostik und Therapie der Non-Hodgkin-Lymphome. Zuckschwerdt, München, S 35–47

    Google Scholar 

  • Bunn PA Jr, Lamberg SI (1979) Report of the Committee on Staging and Classification of Cutaneous T-Cell Lymphomas. Cancer Treat Rep 63: 725–728

    PubMed  Google Scholar 

  • Bunn PA Jr, Hubermann MS, Whang-Peng J et al. (1980) Prospective staging evaluation of patients with cutaneous T-cell lymphomas. Demonstration of a high frequency of extracutaneous dissemination. Ann Intern Med 93: 223–230

    PubMed  Google Scholar 

  • Bunn PA Jr, Fishman AB, Glatstein E (1982) Staging and treatment of the cutaneous T-cell lymphomas (mycosis fungoides and the Sezary syndrome) at the National Cancer Institute (USA). In: Goos M, Christophers M (eds) Lymphoproliferative diseases of the skin. Springer, Berlin Heidelberg New York, pp 270–282

    Google Scholar 

  • Burgers J, Taal B, van Heerde P et al. (1988) Treatment results of primary stage I and II non-Hodgkin’s lymphoma of the stomach. Radiother Oncol 11: 319–326

    PubMed  CAS  Google Scholar 

  • Bush RS, Gospodarowicz M (1982) The place of radiation therapy in the management of patients with localized non-Hodgkin’s lymphoma. In: Rosenberg SA, Kaplan HS (eds) Malignant lymphomas: etiology, immunology, pathology, treatment. Academic Press, New York

    Google Scholar 

  • Byhardt RW, Brace K, Wiernik PM (1975) Role of splenic irradiation in chronic lymphocytic leukemia. Cancer 35: 1622–1625

    Google Scholar 

  • Cabanillas F, Hagemeister F, Bodey G, Freireich E (1982) IMVP-16: An effective regimen for patients with lymphoma who have relapsed after initial combination chemotherapy. Blood 60: 693–697

    Google Scholar 

  • Carbone P, Kaplan HS, Musshoff K, Smithers D, Tubiana M (1971) Report of the committee on Hodgkin’s staging classification. Cancer Res 31: 1860–1861

    PubMed  CAS  Google Scholar 

  • Chen M, Prosnitz L, Gonzalez-Serva A, Fischer D (1979) Results of radiotherapy in control of stage I and II non-Hodgkin’s lymphoma. Cancer 43: 1245–1254

    PubMed  CAS  Google Scholar 

  • Christ G (1985) Ein Verfahren zur Teil-and Ganzkörperbestrahlung mit schnellen Elektronen. Strahlentherapie 161: 410–413

    PubMed  CAS  Google Scholar 

  • Chu A, Berger CL, Lynfield Y (1982) Pathogenesis of cutaneous T-cell lymphoma. In: Christophers GME (ed) Lymphoproliferative diseases of the skin. Springer, Berlin Heidelberg New York, pp 57–67

    Google Scholar 

  • Cogliatti S, Schmid U, Schumacher U et al. (1991) Primary B-cell gastric lymphoma: a clinicopathological study of 145 patients. Gastroenterology lot: 1159–1170

    Google Scholar 

  • Coltman CA, Dahlberg S, Jones SE, Miller TP, Dana BW (1986) CHOP is active in thirty percent of patients with large cell lymphoma: a twelve year Southwest Oncology Group follow up. In: Skarin AT (ed) Advances in cancer chemotherapy: update on treatment for diffuse large cell lymphoma. Park Row, New York, pp 71–77

    Google Scholar 

  • Connors J, Klimo P, Fairey R, Voss N (1987) Brief chemotherapy and involved field radiation therapy for limited stage, histologically aggressive lymphoma. Ann Intern Med 107: 25–30

    PubMed  CAS  Google Scholar 

  • Cox ID (1978) Central lymphatic irradiation to low dose advanced nodular lymphoreticular tumors (non-Hodgkin’s lymphoma). Radiology 126: 767–772

    PubMed  CAS  Google Scholar 

  • Cox JD, Koehl RH, Turner WM, King FM (1974) Irradiation in the local control of malignant lymphoreticular tumors (non-Hodgkin’s malignant lymphoma). Radiology 112: 179–185

    PubMed  CAS  Google Scholar 

  • Cox MT (1964) Malignant lymphoma of the thyroid. J Clin Pathol 17: 591–601

    PubMed  CAS  Google Scholar 

  • D’Angio GJ, Nisce LZ, Kim JH (1975) Weekly total skin electron beam therapy for mycosis fungoides and other cutaneous lymphomata: further experience. Br J Cancer 31: 379

    Google Scholar 

  • David A, Schlosser D, Möckel W, Hebebrand D (1989) Primäre Non-Hodgkin-Lymphome des Magens. Langenbecks Arch Chir 374: 334–339

    PubMed  CAS  Google Scholar 

  • Dawson I, Cornes J, Morson B (1961) Primary malignant lymphoid tumors of the intestinal tract: report of 37 cases with study of factors influencing prognosis. Br J Surg 49: 80–89

    PubMed  CAS  Google Scholar 

  • Doglioni C, Wotherspoon A, Moschini A et al. (1992) High incidence of primary gastric lymphoma in northeastern Italy. Lancet 339: 834–835

    PubMed  CAS  Google Scholar 

  • Dosoretz DE, Raymond AK, Murphy GF et al. (1982) Primary lymphoma of bone: The relationship of morphologic diversity to clinical behaviour. Cancer 5o: 1009–1014

    Google Scholar 

  • Economopoulos T, Asprou N, Stathakis N et al. (1992) Primary extranodal non-Hodgkin’s lymphoma of the head and neck. Oncology 49: 484–488

    PubMed  CAS  Google Scholar 

  • Edelson RL (1975) Cutaneous T cell lymphomas, perspective (NIH Conference). Ann Intern Med 83: 568

    Google Scholar 

  • Edelstein GR, Clark T, Holt JG (1973) Dosimetry for total-body electron-beam therapy in the treatment of mycosis fungoides. Radiology 108: 691–694

    PubMed  CAS  Google Scholar 

  • Engelhard M, Löffler M (1993) Klinisch relevante Prognosefaktoren maligner Lymphome. Internist 34: 127–131

    PubMed  CAS  Google Scholar 

  • Engelhard M, Meusers P, Brittinger G et al. (1991) Prospective multicenter trial for the response-adapted treatment of high-grade malignant non-Hodgkin’s lymphomas. Updated results of the COP-BLAM/IMVP-16 protocol with randomized adjuvant radiotherapy. Ann Oncol 2 [Suppl 2]: 177–180

    PubMed  Google Scholar 

  • Feller AC (1993) Pathologische Anatomie and Immunhistolo- gie der Non-Hodgkin-Lymphome. Internist 34: 106–113

    PubMed  CAS  Google Scholar 

  • Fisher R, Gaynor E, Dahlberg S et al. (1993) Comparison of standard regimen ( CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin’s lymphoma. N Engl J Med 328: 1002–1006

    Google Scholar 

  • Fitzpatrick P, Macko S (1984) Lymphoreticular tumors of the orbit. Int J Radiat Oncol Biol Phys 10: 333–340

    PubMed  CAS  Google Scholar 

  • Fleming I, Mitchell S, Dilawari R (1982) The role of surgery in the management of gastric lymphoma. Cancer 49: 1135–1141

    PubMed  CAS  Google Scholar 

  • Foon KA, Rai KR, Gale RP (1990) Chronic lymphocytic leukemia: new insights into biology and therapy. Ann Intern Med 113: 525–539

    PubMed  CAS  Google Scholar 

  • Forman D, Newell D, Fullerton F et al. (1991) Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. Br J Cancer 302: 1302–1305

    CAS  Google Scholar 

  • Freeman CR, Suissa S, Shenouda G et al. (1992) Clinical experience with a single field rotational total skin electron irradiation technique for cutaneous T-cell lymphoma. Radiother Oncol 24: 155–162

    PubMed  CAS  Google Scholar 

  • Gärtner HV, Schumm G, Steinke B (1989) Non-HodgkinLymphom and Adenokarzinom des Magens. Tumordiagn Ther 10: 38–43

    Google Scholar 

  • Gerhartz H, Engelhard M, Meusers P et al. (1993) Randomized double-blind placebocontrolled, phase-III study of recombinant human granulocyte-macrophage colony-stimulating factors as adjunct to induction treatment of high-grade malignant non-Hodgkin’s lymphomas. Blood 82: 2329–2339

    PubMed  CAS  Google Scholar 

  • Gobbi P, Dionogi P, Barbieri F et al. (1990) The role of surgery in the multimodal treatment of primary gastric non-Hodgkin’s lymphomas–a report of 76 cases and review of literature. Cancer 65: 2528–2536

    PubMed  CAS  Google Scholar 

  • Goffinet DR, Glatstein E, Fuks Z, Kaplan HS (1976) Abdominal irradiation in non-Hodgkin’s lymphoma. Cancer 37: 2797

    PubMed  CAS  Google Scholar 

  • Goldwein J, Coia L, Hanks G (1991) Prognostic factors in patients with early stage non-Hodgkin’s lymphoma of the head and neck treated with definitive irradiation. Int J Radiat Oncol Biol Phys 20: 45–51

    PubMed  CAS  Google Scholar 

  • Gonzalez D, Schuster-Uitterhoeve ALJ (1983) Primary non-Hodgkin’s lymphoma of the central nervous system: results of radiotherapy in 15 cases. Cancer 51: 2048–2052

    PubMed  CAS  Google Scholar 

  • Gordon L, Harrington D, Andersen J et al. (1992) Comparison of second-generation combination chemotherapeutic regimen (m-BACOP) with a standard regimen ( CHOP) for advanced diffuse “ non-Hodgkin’s lymphoma. N Eng J Med 327: 1342–1349

    Google Scholar 

  • Gospodarowicz M, Bush R, Brown T, Chua T (1983) Curability of gastrointestinal lymphoma with combined surgery and radiation. Int J Radiat Oncol Biol Phys 9: 3–9

    PubMed  CAS  Google Scholar 

  • Gospodarowicz M, Bush R, Brown T, Chua T (1984) Prognostic factors in nodular lymphomas. A multivariate analysis based on the Princess Margaret Hospital experience. Int J Radiat Oncol Biol Phys 10: 489–497

    Google Scholar 

  • Grangier C, Coucke P, Croisille P et al. (1994) Primary cerebral lymphoma. Strahlenther Onko1170: 206–212

    Google Scholar 

  • Gribben J, Goldstone A, Lich D et al. (1989) Effectiveness of high-dose combination chemotherapy and autologous bone marrow transplantation for patients with non-Hodgkin’s lymphomas who are still responsive to conventional-dose chemotherapy. J Clin Oncol 7: 1621–1629

    PubMed  CAS  Google Scholar 

  • Haber D, Mayer R (1988) Primary gastrointestinal lymphoma. Semin Oncol 15: 154–169

    PubMed  CAS  Google Scholar 

  • Hamburger JI, Miller M, Kini SH (1983) Lymphoma of the thyroid. Ann Intern Med 99: 685–693

    PubMed  CAS  Google Scholar 

  • Harris NL, Jaffe ES, Stein H et al. (1994) A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood 84: 1361–1392

    PubMed  CAS  Google Scholar 

  • Havemann K, Köppler H, Brittinger G, Steinke B (1993) Therapiestrategien für hochmaligne Non-Hodgkin-Lymphome. Internist 34: 139–145

    PubMed  CAS  Google Scholar 

  • Hayes J, Dunn E (1989) Has the incidence of primary gastric lymphoma increased? Cancer 63: 2073–2076

    PubMed  CAS  Google Scholar 

  • Henry JH, Heffner RR Jr, Dillard SH, Earle KM, Davis RL (1974) Primary malignant lymphomas of the nervous system. Cancer 34: 1293–1302

    PubMed  CAS  Google Scholar 

  • Herrera A, Solal-Celigny P, Gaulard P et al. (1984) Primary lymphomas of the gastrointestinal tract: results of treatment in a series of 35 cases. Gastroenterol Clin Biol 8: 407–413

    PubMed  CAS  Google Scholar 

  • Hermann R, Panahon A, Barcos M, Walsh D, Stutzman L (1980) Gastrointestinal involvement in non-Hodgkin’s lymphoma. Cancer 46: 215–222

    Google Scholar 

  • Hiddemann W, Unterhalt M, Koch P, Nahler M, Herrmann R, van de Loo J (1991) Alpha interferon maintenance therapy in patients with low-grade non-Hodgkin’s lymphomas after cytoreductive chemotherapy with prednimustine and mitoxantrone. Eur J Cancer 27 [Suppl 4]: 37–39

    Google Scholar 

  • Hiller E, Wilmanns W (1991) Bedeutung der Chemound Radiotherapie bei gastrointestinalen Lymphomen. Chirurg 62: 457–461

    PubMed  CAS  Google Scholar 

  • Hochberg FH, Miller DC (1988) Primary central nervous system lymphoma. J Neurosurg 68: 835–853

    PubMed  CAS  Google Scholar 

  • Hoppe RT, Fuks Z, Bagshaw MA (1979) Radiation therapy in the management of cutaneous T-cell lymphomas. Cancer Treat Rep 63: 625–632

    PubMed  CAS  Google Scholar 

  • Hoppe RT, Kushlan P, Kaplan HS et al. (1981) The treatment of advanced stage favourable histology non-Hodgkin’s lymphomas: a preliminary report of a randomized trial comparing single agent chemotherapy, combination chemotherapy, and whole body irradiation. Blood 58: 592–598

    PubMed  CAS  Google Scholar 

  • Hoppe RT, Wood GS, Abel EA (1990) Mycosis fungoides and the Sézary syndrome: pathology, staging, and treatment. Curr Probl Cancer 14: 295–361

    Google Scholar 

  • Horning SJ (1994) Low-grade lymphoma 1993: State of the art. Ann Oncol 5 [Suppl e]: 23–27

    PubMed  Google Scholar 

  • Horning SJ, Rosenberg SA (1984) The natural history of initially untreated low-grade non-Hodgkin’s lymphoma. N Engl J Med 311: 1471–1475

    PubMed  CAS  Google Scholar 

  • Isaacson P, Wright D (1984) Extranodal malignant lymphoma arising from mucosa-associated lymphoid tissue. Cancer 53: 2515–2524

    PubMed  CAS  Google Scholar 

  • Jacobs C, Hoppe R (1985) Non-Hodgkin’s lymphomas of head and neck extranodal sites. Int J Radiat Oncol Biol Phys 11: 357–364

    PubMed  CAS  Google Scholar 

  • Jähne J, Meyer HJ, Wilke H et al. (1990) Die Bedeutung der chirurgischen Therapie bei primären and sekundären Non-Hodgkin-Lymphomen des Magens im multimodalen Behandlungskonzept. Tumordiagn Ther 11: 272–279

    Google Scholar 

  • Jaffe ES (1990) The role of immunophenotypic markers in the classification of non-Hodgkin’s lymphomas. Semin Oncol 17: 11–19

    PubMed  CAS  Google Scholar 

  • Jellinger K, Radaskiewicz T, Slowik F (1975) Primary malignant lymphoma of the central nervous system in man. Acta Neuropathol Suppl 6: 95–102

    PubMed  Google Scholar 

  • Jellinger K, Budka H, Slowik F (1988) Pathologie und Immunmorphologie primärer Lymphome des Zentralnervensystems. In: Bamberg M, Sack H (Hrsg) Therapie primärer Hirntumoren. Zuckschwerdt, München, S 306–317

    Google Scholar 

  • Johnson RE (1979) Treatment of chronic lymphocytic leukemia by total body irradiation alone and combined with chemotherapy. Int J Radiat Oncol Biol Phys 5: 159–164

    PubMed  CAS  Google Scholar 

  • Johnson RE, Rühl U (1976) Treatment of chronic lymphocytic leukemia with emphasis on total body irradiation. Int J Radiat Oncol Biol Phys 1: 387–397

    PubMed  CAS  Google Scholar 

  • Jones GW, Tadros A, Hodson DI et al. (1994) Prognosis with newly diagnosed mycosis fungoides after total skin electron radiation of 30 or 35 Gy. Int J Radiat Oncol Biol Phys 28: 839–845

    PubMed  CAS  Google Scholar 

  • Jones S, Miller T, Connors J (1989) Long-term follow-up and analysis for prognostic factors for patients with limited-stage large-cell lymphoma treated with initial chemotherapy with or without adjuvant radiotherapy. J Clin Oncol 7: 1186–1191

    PubMed  CAS  Google Scholar 

  • Jones S, Fuks Z, Kaplan HS, Rosenberg SA (1973) Non-Hodgkin’s lymphomas. V. Results of radiotherapy. Cancer 32: 682–691

    Google Scholar 

  • Kahler O (1889) Zur Symptomatologie des multiplen Myeloms: Beobachtungen von Albumosurie. Prag Med Wochenschr 14: 45–49

    Google Scholar 

  • Kaminski M, Coleman C, Colby T et al. (1986) Factors predicting survival in adults with stage I and II large-cell lymphoma treated with primary radiation therapy. Ann Intern Med 104: 747–756

    PubMed  CAS  Google Scholar 

  • Karzmark CJ, Loevinger R, Steele R, Weissbeth M (1960) A technique for large field superficial electron therapy. Radiology 74: 633–643

    PubMed  CAS  Google Scholar 

  • Kaye FJ, Bunn PA, Steinberg SM et al. (1989) A randomized trial comparing combination electron-beam radiation and chemotherapy with topical therapy in initial treatment of mycosis fungoides. N Engl J Med 321: 1784–1790

    PubMed  CAS  Google Scholar 

  • Köppler H, Pflüger K, Eschenbach I et al. (1991) Sequential versus alternating chemotherapy for high-grade non-Hodgkin’s lymphomas: a randomized multicentre trial. Hematol Oncol 9: 217–223

    PubMed  Google Scholar 

  • Kresbach H, Kerl H (1983) Maligne Lymphome. In: Luger A, Gschnait F (Hrsg) Dermatologische Onkologie. Urban & Schwarzenberg, München, S 204–258

    Google Scholar 

  • Kuten A, Ben-Shahar M, Epelbaum R et al. (1989) Results of radiotherapy in stage I to II extranodal non-Hodgkin’s lymphoma of the head and neck. Strahlenther Onko1165: 578–583

    Google Scholar 

  • Lawrence TS, Urba W, Steinberg S et al. (1988) Retrospective analysis of stage I and II indolent lymphomas at the National Cancer Institute. Int J Radiat Oncol Biol Phys 14: 417–424

    PubMed  CAS  Google Scholar 

  • LeBeau M (1990) Chromosomal abnormalities in non-Hodgkin’s lymphomas. Semin Onco117: 20–29

    Google Scholar 

  • Lennert K (1952) Zur histologischen Diagnose der Lymphogranulomatose. Habilitationsschrift, Universität Frankfurt

    Google Scholar 

  • Lennert K, Feller AC (1990) Histopathologie der NonHodgkin-Lymphome (nach der aktualisierten Kiel-Klassifikation), 2. Aufl. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Lennert K, Feller AC (1992) Histopathology of non-Hodgkin’s lymphomas, 2nd edn. Springer, Berlin Heidelberg New York Tokyo

    Google Scholar 

  • Lerman-Sagie T, Ziv Y, Rubin M et al. (1985) Gastric lymphoma versus pseudolymphoma: the importance of immunological differentiation. Am J Gastroenterol 80: 763–766

    PubMed  CAS  Google Scholar 

  • Letscher J, Gonzalez-Gonzalez D, Oskam J et al. (1991) Results of radiotherapy in patients with stage I orbital non-Hodgkin’s lymphoma. Radiother Oncol 22: 36–44

    Google Scholar 

  • Levitt S, Bloomfield C, Fizzera G, Lee C (1980) Curative radiotherapy for localized diffuse histiocytic lymphoma. Cancer Treat Rep 64: 175–177

    PubMed  CAS  Google Scholar 

  • Lewin K, Ranchod M, Dorfman R (1978) Lymphomas of the gastrointestinal tract–a study of 117 cases presenting with gastrointestinal disease. Cancer 42: 693–707

    PubMed  CAS  Google Scholar 

  • Loeffler JS, Ervin TJ, Mauch P et al. (1985) Primary lymphoma of the central nervous system: patterns of failure and factors that influence survival. J Clin Oncol 3: 490–494

    PubMed  CAS  Google Scholar 

  • Longo D, Glatstein E, Duffey P (1989) Treatment of localised aggressive lymphoma with combination chemotherapy followed by involved-field radiation therapy. J Clin Oncol 9: 1295–1302

    Google Scholar 

  • Ludwig H (1982) Multiples Myelom. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Lukes R, Collins R (1974) Immunologic characterization of human malignant lymphomas. Cancer 34: 1488–1503

    PubMed  Google Scholar 

  • Maor M, Maddux B, Osborne B et al. (1984) Stages IE and IIE non-Hodgkin’s lymphomas of the stomach–comparison of treatment modalities. Cancer 54: 2330–2337

    PubMed  CAS  Google Scholar 

  • Maor M, Velasquez W, Fuller L, Silvermintz K (1990) Stomach conservation in stages IE and IIE gastric non-Hodgkin’s lymphoma. J Clin Oncol 8: 266–271

    PubMed  CAS  Google Scholar 

  • McKelvey E, Gottlieb J, Wilson H et al. (1976) Hydroxyldaunomycin (adriamycin) combination chemotherapy in malignant lymphoma. Cancer 38: 1484–1493

    PubMed  CAS  Google Scholar 

  • McLaughlin P, Fuller L, Velasquez W et al. (1986) Stage I-II follicular lymphoma. Cancer 58: 1596–1602

    PubMed  CAS  Google Scholar 

  • McLaughlin P, Fuller L, Redman J et al. (1991) Stage I-II low-grade lymphomas: a prospective trial of combination chemotherapy and radiotherapy. Ann Oncol 2 [Suppl e]: 137–140

    PubMed  Google Scholar 

  • Mendenhall NP, Thar TL, Agee OF et al. (1983) Primary lymphoma of the central nervous system: CT scan characteristics and treatment results for 12 cases. Cancer 52: 1993–2000

    PubMed  CAS  Google Scholar 

  • Mendenhall NP, Noyes WD et al. (1989) Total body irradiation for stage IL-IV non-Hodgkin’s lymphoma: ten year follow-up. J Clin Oncol 7: 67–74

    PubMed  CAS  Google Scholar 

  • Micaily B, Moser C, Vonderheid EC et al. (1990) The radiation therapy of early stage cutaneous T-cell lymphoma. Int J Radiat Oncol Biol Phys 18: 1333–1339

    PubMed  CAS  Google Scholar 

  • Mill W, Lee F, Franssila K (1980) Radiation therapy treatment of stage I and II extranodal non-Hodgkin’s lymphoma of the head and neck. Cancer 45: 653–661

    PubMed  CAS  Google Scholar 

  • Minehan K, Martenson J, Garrity J et al. (1991) Local control and complications after radiation therapy for primary orbital lymphoma: a case for low-dose treatment. Int J Radiat Oncol Biol Phys 20: 791–796

    PubMed  CAS  Google Scholar 

  • Müller C, Steinke B, Emmig C, Konrad E (1990) NonHodgkin-Lymphome der Lid-und Orbitaregion. Tumordiagn Ther 11: 129–133

    Google Scholar 

  • Müller RG, Lux HJ, Herbst M (1984) Ganzhaut-Elektronentherapie: Ein Therapiekonzept bei Mycosis fungoides und Sézary-Syndrom. Strahlentherapie 160: 90–95

    Google Scholar 

  • Müller-Hermelink HK (1988) Autoimmunerkrankungen und maligne Lymphome. In: Wilms K, tackle H, Meyer P (Hrsg) Diagnostische und therapeutische Entwicklungen in der Hämatologie und Onkologie. Zuckschwerdt, München, S 247–260

    Google Scholar 

  • Mundy GR, Raisz LG, Cooper RA et al. (1974) Evidence for a secretion of an osteoclast stimulating factor in myeloma. New Engl J Med 291: 1041–1046

    PubMed  CAS  Google Scholar 

  • Murray K, Kun L, Cox J (1986) Primary malignant lymphoma of the central nervous system. J Neurosurg 65: 600–607

    PubMed  CAS  Google Scholar 

  • Musshoff K (1987) Maligne Systemerkrankungen. In: Scherer E (Hrsg) Strahlentherapie, 3. Aufl. Springer, Berlin Heidelberg New York Tokyo, S 1080–1332

    Google Scholar 

  • Musshoff K, Schmidt-Vollmer H (1975) Prognosis of non-Hodgkin’s lymphomas with special emphasis on staging classification. Z Krebsforsch 83: 232–341

    Google Scholar 

  • Nelson DF, Martz KL, Bonner H et al. (1992) Non-Hodgkin’s lymphoma of the brain: Can high dose, large volume radiation therapy improve survival? Report on a prospective trial by Radiation Therapy Oncology Group (RTOG): RTOG 8215. Int J Radiat Oncol Biol Phys 23: 9–17

    PubMed  CAS  Google Scholar 

  • Neuwelt EA, Frenkel EP, Gumerlock MK et al. (1986) Developments in the diagnosis and treatment of primary CNS lymphoma. Cancer 58: 1609–1620

    PubMed  CAS  Google Scholar 

  • Nissen N, Ersboll J, Hansen H et al. (1983) A randomized study of radiotherapy versus radiotherapy plus chemotherapy in stage I-II non-Hodgkin’s lymphomas. Cancer 52: 1–7

    PubMed  CAS  Google Scholar 

  • Non-Hodgkin’s Lymphoma Pathological Classification Project (1982) NC1-sponsored study of classifications of non-Hodgkin’s lymphoma. Cancer 49: 2112–2135

    Google Scholar 

  • Nunez G, London L, Hochenbery D, Alexander M et al. (1990) Deregulated bd-2 gene expression selectively prolongs survival of growth factor-deprived hemopoetic cell lines. J Immunol 144: 3602–3610

    PubMed  CAS  Google Scholar 

  • O’Connell N, Harrington D, Earle J et al. (1988) Chemotherapy followed by consolidation radiation therapy for the treatment of clinical stage II aggressive histologic type non-Hodgkin’s lymphoma. Cancer 61: 1754–1758

    PubMed  Google Scholar 

  • Ossenkoppele G, Mol J, Snow G et al. (1987) Radiotherapy versus radiotherapy plus chemotherapy in stages I and II non-Hodgkin’s lymphoma of the upper digestive and respiratory tract. Cancer 6o: 1505–1509

    Google Scholar 

  • Ostrowski ML, Unni KK, Banks PM et al. (1986) Malignant lymphoma of bone. Cancer 58: 2646–2655

    PubMed  CAS  Google Scholar 

  • Otter R, Bieger R, Kluin P et al. (1989 a) Primary gastrointestinal non-Hodgkin’s lymphoma in a population-based registry. Br J Cancer 6o: 745–750

    Google Scholar 

  • Otter R, Gerrits W, Sandt M et al. (1989b) Primary extranodal and nodal non-Hodgkin’s lymphoma–a survey of a population-based registry. Eur J Cancer 25: 1203–1210

    CAS  Google Scholar 

  • Page V, Gardner A, Karzmark CJ (1970) Patient dosimetry in the electron treatment of large superficial lesions. Radiology 94: 635–641

    PubMed  CAS  Google Scholar 

  • Parlier Y, Najman A, Lecomte D et al. (1985) Results of a cooperative prospective study of treatment of primary digestive localizations of non-Hodgkin’s lymphoma. Gastroenterol Clin Biol 9: 922–928

    PubMed  CAS  Google Scholar 

  • Paryani SB, Hoppe RT, Cox RS et al. (1983) Analysis of non-Hodgkin’s lymphomas with nodular and favorable histologies, stages I and II. Cancer 52: 2300–2307

    PubMed  CAS  Google Scholar 

  • Peters MV, Bush RS, Brown TC, Reid J (1975) The place of radiotherapy in the control of non-Hodgkin’s lymphoma. Br J Cancer 31 [Suppl 2]: 386–401

    Google Scholar 

  • Portlock C (1990) Management of low-grade non-Hodgkin’s lymphomas. Semin Onco117: 51–59

    Google Scholar 

  • Qualman S, Mendelsohn G, Mann R, Green W (1983) Intra-ocular lymphomas. Natural history based on a clinico-pathologic study of eight cases and review of the literature. Cancer 52: 878–886

    Google Scholar 

  • Radaszkiewicz T, Dragosics B, Bauer P (1992) Gastrointestinal malignant lymphomas of the mucosa-associated lymphoid tissue. Factors relevant to prognosis. Gastroenterology 102: 1628–1638

    Google Scholar 

  • Rai KR, Sawitsky A, Cronkite EP et al. (1975) Clinical staging of chronical lymphatic leukemia. Blood 46: 219–234

    PubMed  CAS  Google Scholar 

  • Rampen FH, van Andel JG, Sizoo W, van Unnik JAM (1980) Radiation therapy in primary Non-Hodgkin’s lymphoma of the CNS. Eur J Cancer 16: 177–184

    PubMed  CAS  Google Scholar 

  • Rappaport H (1966) Tumors of the hemopoetic system. Atlas of tumor pathology, III/8. Armed Forces Institute of Pathology, Washington/DC

    Google Scholar 

  • Rathmell AJ, Gospodarowicz MK, Sutcliffe SB, Clark RM (1992) The Princess Margret Hospital Lymphoma Group: Localised lymphoma of the bone: prognostic factors and treatment recommendations. Br J Cancer 66: 603–606

    PubMed  CAS  Google Scholar 

  • Read G (1981) Lymphomas of the testis - results of treatment 1960–1977. Clin Radio 32: 687

    CAS  Google Scholar 

  • Reddy E, Bhatia P, Evans R (1988) Primary orbital lymphomas. Int J Radiat Oncol Biol Phys 15: 1239–1241

    PubMed  CAS  Google Scholar 

  • Ree H, Rege V, Knisley E et al. (1980) Malignant lymphoma of Waldeyer’s ring following gastrointestinal lymphoma. Cancer 46: 1528–1535

    PubMed  CAS  Google Scholar 

  • Roth SL, Sack H, Schaeben W et al. (1984) Primär extranodale Non-Hodgkin-Lymphome. In: Diehl V, Sack H (Hrsg) Diagnostik and Therapie der Non-Hodgkin-Lymphome. Zuckschwerdt, München, S 139–177

    Google Scholar 

  • Sack H, Thesen N (1993) Bestrahlungsplanung. Thieme, Stuttgart

    Google Scholar 

  • Salles G, Shipp M, Coiffier B (1994) Chemotherapy of nonHodgkin’s lymphomas. Semin Hematol 31: 46–69

    PubMed  CAS  Google Scholar 

  • Sandler R (1984) Has primary gastric lymphoma become more common? J Clin Gastroenterol 6: 101–107

    PubMed  CAS  Google Scholar 

  • Saul S, Kappadia S (1985) Primary lymphoma of Waldeyer’s ring: clinicopathologic study of 68 cases. Cancer 56: 157–166

    PubMed  CAS  Google Scholar 

  • Schwarze E (1983) Primär extranodale Non-Hodgkin-Lymphome: Ihre Histopathologie, bevorzugte Lokalisation, Häufigkeit und Pathogenese. In: Diehl V, Sack H (Hrsg) Diagnostik und Therapie der Non-Hodgkin-Lymphome. Zuckschwerdt, München (Aktuelle Onkologie, Bd 12, S 131–137 )

    Google Scholar 

  • Sheridan W, Medley G, Brodie G (1985) Non-Hodgkin’s lymphoma of the stomach: a prospective pilot study of surgery plus chemotherapy in early and advanced disease. J Clin Oncol 3: 495–500

    PubMed  CAS  Google Scholar 

  • Shimm D, Dosoretz D, Anderson T et al. (1983) Primary gastric lymphoma. An analysis with emphasis on prognostic factors and radiation therapy. Cancer 52: 2044–2048

    Google Scholar 

  • Shimm D, Dosoretz D, Harris N et al. (1984) Radiation ther- apy of Waldeyer’s ring lymphoma. Cancer 54: 426–431

    PubMed  CAS  Google Scholar 

  • Shipp M, Harrington D, Anderson J et al. (1992) Development of a predictive model for aggressive lymphoma: the international NHL prognostic factors project. Am Soc Clin Oncol Proc 11: 319 (Abstract 1084)

    Google Scholar 

  • Shutze W, Halpern N (1991) Gastric lymphoma. Surg Gynecol Obstet 172: 33–38

    PubMed  CAS  Google Scholar 

  • Smalley RV, Andersen JW, Hawkins MJ et al. (1992) Interferon alpha combined with cytotoxic chemotherapy for patients with non-Hodgkin’s lymphoma. N Engl J Med 327: 1336–1341

    PubMed  CAS  Google Scholar 

  • Smith M, Brustein S, Straus D (1987) Localized nonHodgkin’s lymphoma of the breast. Cancer 59: 351–354

    PubMed  CAS  Google Scholar 

  • Smithers DW (1970) Malignant lymphomas of the thyroid gland. Engl Monogr Neopl Dis 6: 141

    CAS  Google Scholar 

  • Smitt M, Donaldson S (1993) Radiotherapy is successful treatment for orbital lymphoma. Int J Radiat Oncol Biol Phys 26: 59–66

    PubMed  CAS  Google Scholar 

  • Snow RB, Lavyne MH (1985) Intracranial space-occupying lesions in AIDS patients. Neurosurgery 16: 148–153

    PubMed  CAS  Google Scholar 

  • So YT, Beckstead JH, Davis RL (1986) Primary central nervous system lymphoma in AIDS: a clinical and pathologic study. Ann Neurol 20: 566–572

    PubMed  CAS  Google Scholar 

  • Souhami L, Simpson WJ, Carruthers JS (1980) Malignant lymphoma of the thyroid gland. Int J Radiat Oncol Biol Phys 6: 1143–1147

    PubMed  CAS  Google Scholar 

  • Stein H, Gerdes J (1986) Phänotypische und genotypische Marker bei malignen Lymphomen: Ein Beitrag zum zellulären Ursprung des Morbus Hodgkin und der malignen Histiozytose sowie Implikationen für die Klassifikation der T-Zell-und B-Zell-Lymphome. Verh Dtsch Ges Path 70: 127–151

    Google Scholar 

  • Stein H, Dallenbach F, Dienemann D (1988) Differenzierungslinien physiologischer und maligner Zellen des lymphatischen Systems. Verh Dtsch Ges Path 72: 57–85

    CAS  Google Scholar 

  • Steinke B (1989) Stellenwert der Chemotherapie bei gastroin- testinalen Lymphomen. Verdauungskrankheiten 7: 53–60

    Google Scholar 

  • Steinke B, Manegold C, Freund M et al. (1992) G-CSF for treatment intensification in high-grade non-Hodgkin’s lymphomas. Onkologie 15: 46–50

    Google Scholar 

  • Steward W, Harris M, Wagstaff J et al. (1985) A prospective study of the treatment of high-grade histology non-Hodgkin’s lymphoma involving the gastrointestinal tract. Eur J Cancer 21: 1195–1200

    CAS  Google Scholar 

  • Stolte M (1992) Helicobacter pylori gastritis and gastric MALT lymphoma. Lancet 339: 745–746

    PubMed  CAS  Google Scholar 

  • Stolte M, Eidt S (1989) Lymphoid follicles in the antral mucosa: immune response to Campylobacter pylori? J Clin Pathol 42: 1269–1271

    PubMed  CAS  Google Scholar 

  • Sussman EB, Hajdu SJ, Lieberman PH, Whitmore WF (1977) Malignant lymphomas of the testis. J Uro1118: 1004

    Google Scholar 

  • Sutcliffe SB, Gospadarowicz M, Bush RS et al. (1985) Role of radiation therapy in localized non-Hodgkin’s lymphoma. Radiother Oncol 4: 211–223

    PubMed  CAS  Google Scholar 

  • Sweet D, Kinzie J, Gaeke M et al. (1981) Survival of patients with localized diffuse histiocytic lymphoma. Blood 58: 1218–1223

    PubMed  CAS  Google Scholar 

  • Symmers D (1927) Follicular lymphadenopathy with splenomegaly. A newly recognized disease of the lymphatic system. Arch Pathol 3: 816

    Google Scholar 

  • Szur L (1975) The treatment of mycosis fungoides and related conditions with particular emphasis on electron therapy. Br J Cancer 31: 368

    Google Scholar 

  • Taal B, Den Hartog Jager F, Burgers J et al. (1989) Primary non-Hodgkin’s lymphoma of the stomach: changing aspects and therapeutic choices. Eur J Cancer 25: 439–450

    CAS  Google Scholar 

  • Tadros AAM, Tepperman BS, Hryniuk WM et al. (1983) Total skin electron irradiation for mycosis fungoides: failure analysis and prognostic factors. Int J Radiat Oncol Biol Phys 9: 1279–1287

    PubMed  CAS  Google Scholar 

  • Terstappen LW, de Groth BG, van Berkel W et al. (1988) The effect of splenic irradiation on lymphocytic subpopulations in chronic B-lymphocytic leukemia. Eur J Haematol 41: 496–505

    PubMed  CAS  Google Scholar 

  • Tesch H, Stein H, Diehl V (1993) Zell-and Molekularbiologie von malignen Lymphomen. Internist 34: 89–96

    PubMed  CAS  Google Scholar 

  • Tondini C, Zanini M, Lombardi F et al. (1993) Combined modality treatment with primary CHOP chemotherapy followed by locoregional irradiation in stage I or II histology aggressive non-Hodgkin’s lymphomas. J Clin Oncol 11: 720–725

    PubMed  CAS  Google Scholar 

  • Toonkel L, Fuller L, Gamble J et al. (1980) Laparotomy stages I and II non-Hodgkin’s lymphomas: preliminary results of radiotherapy and adjunctive chemotherapy. Cancer 45: 249–260

    PubMed  CAS  Google Scholar 

  • Tupchong L, Phil D, Hughes F, Harmer CL (1986) Primary lymphoma of the thyroid: clinical features, prognostic factors, and results of treatment. Int J Radiat Oncol Biol Phys 12: 1813–1821

    PubMed  CAS  Google Scholar 

  • Twefik H, Platz C, Corder M et al. (1979) A clinicopathologic study of orbital and adnexal non-Hodgkin’s lymphoma. Cancer 44: 1022–1028

    Google Scholar 

  • Van der Merwe DG (1993) Total skin electron therapy: a technique which can be implemented on a conventional linear accelerator. Int J Radiat Oncol Biol Phys 27: 391–396

    Google Scholar 

  • Verreet P, Borchard F, Stöltzing H et al. (1990) Stellenwert der Gastrektomie im multimodalen Therapiekonzept des primären Non-Hodgkin-Lymphom des Magens. Langenbecks Arch Chir 375: 151–155

    PubMed  CAS  Google Scholar 

  • Vokes E, Ultman J, Golomb H et al. (1985) Long-term survival of patients with localized diffuse histiocytic lymphoma. J Clin Oncol 3: 1309–1317

    PubMed  CAS  Google Scholar 

  • Wehinger H, Slanina J, Jacobi H et al. (1974) Prophylactic central nervous system therapy with cranial irradiation and intrathecal methotrexate in acute lymphoblastic leukaemia of childhood. Strahlentherape 148: 590–598

    CAS  Google Scholar 

  • Weingrad D, Decosse J, Sherlock P et al. (1982) Primary gastrointestinal lymphoma: a 3o year review. Cancer 49: 1258–1265

    PubMed  CAS  Google Scholar 

  • Wotherspoon A, Ortiz-Hidalgo C, Galzon M, Isaacson P (1991) Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet 338: 1175–1176

    PubMed  CAS  Google Scholar 

  • Wulfrank D, Speelman T, Pauwels C et al. (1987) Extranodal non-Hodgkin’s lymphoma of the head an neck. Radiother Oncol 8: 199–207

    PubMed  CAS  Google Scholar 

  • Zukerberg L, Ferry J, Southern J, Harris N (1990) Lymphoid infiltrates of the stomach. Evaluation of histologic criteria for the diagnosis of low-grade gastric lymphoma on endoscopic biopsy specimens. Am J Surg Pathol 14: 1087–1099

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. H. Sack
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Hoederath
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Stuschke
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Strahlenklinik, Universitätsklinikum Essen, Hufelandstraße 55, 45122, Essen, Deutschland

    Eberhard Scherer  & Horst Sack  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Sack, H., Hoederath, A., Stuschke, M. (1996). Non-Hodgkin-Lymphome. In: Scherer, E., Sack, H. (eds) Strahlentherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79432-2_40

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-79432-2_40

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79433-9

  • Online ISBN: 978-3-642-79432-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation