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Genetic Heterogeneity and Phenotype Variation of Schizophrenia

  • Conference paper
Search for the Causes of Schizophrenia

Abstract

It is well proven that the manifestation of schizophrenia is under genetic control (Kendler and Diehl 1993). It is however less clear:

  1. 1.

    How relevant environmental factors are, and how they operate and interact with genetic factors.

  2. 2.

    If the genetic susceptibility is identical across the total population of schizophrenics (or at least across all subjects with familial schizophrenia), or if the specific genetic components vary across families.

  3. 3.

    What is transmitted in families of schizophrenics and how co-familial traits are related to genetic and genetic risk factors; are only disorders and symptoms that belong to the schizophrenic sepctrum transmitted or are neurophysiological, neuropsychological, or biochemical correlates also transmitted (independent of the occurrence of the disease)?

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  1. Department of Psychiatry, University of Mainz, Untere Zahlbacher Str. 8, 55101, Mainz, Germany

    W. Maier

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  1. Central Institute of Mental Health, P.O. Box 122120, 68072, Mannheim, Germany

    Heinz Häfner  & Wagner Farid Gattaz  & 

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Maier, W. (1995). Genetic Heterogeneity and Phenotype Variation of Schizophrenia. In: Häfner, H., Gattaz, W.F. (eds) Search for the Causes of Schizophrenia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79429-2_10

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