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Cervix Uteri Carcinoma

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Book cover Prognostic Factors in Cancer

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Abstract

Carcinoma of the cervix accounts for approximately one fifth of all gynecologic cancers and 2% of all malignancies in women. Numerous prognostic factors have been studied in patients with cervical carcinoma, using both univariate and multivariate analyses. Differences in end points of analysis, whether survival (disease-free or overall), relapse-free rate or local control rate, make comparisons of such studies difficult. Stage, histologic type and histologic grade are the commonly considered factors and have recently been joined by biologic factors including DNA ploidy, S-phase fraction and oncogene expression. Not all factors are relevant to all patients; for example, depth of tumor invasion and presence of vascular space invasion may only be reliably determined in patients treated with surgery, whereas hemoglobin level is important in patients treated with radiation. This review will concentrate largely on those factors identified using multivariate techniques, such as log rank or Cox regression analysis, in order to account for interactions between various factors and will present estimates such as hazard ratios, where available, in order to indicate the strengths of individual variables.

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Authors
  1. A. Fyles
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  2. P. Kirkbride
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Editor information

Editors and Affiliations

  1. Chirurgische Universitätsklinik Erlangen, Krankenhausstr. 12, 91054, Erlangen, Germany

    P. Hermanek (Vorstand der Abteilung für Klinische Pathologie i. R.) (Vorstand der Abteilung für Klinische Pathologie i. R.)

  2. Princess Margaret Hospital, Department of Radiation Oncology, University of Toronto, 500 Sherbourne Street, Toronto, Ontario, M4X 1K9, Canada

    Mary K. Gospodarowicz

  3. Early Detection Branch, Division of Cancer Prevention and Control, National Cancer Institute, EPN Building, Room 305 9000 Rockville Pike, Bethesda, MD, 20892, USA

    D. E. Henson

  4. University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ, USA

    R. V. P. Hutter (Clinical Professor of Pathology) (Clinical Professor of Pathology)

  5. Department of Pathology, Saint Barnabas Medical Center, Old Short Hills Road, Livingston, NJ, 07039, USA

    R. V. P. Hutter (Clinical Professor of Pathology) (Clinical Professor of Pathology)

  6. Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    L. H. Sobin (Professor of Pathology) (Professor of Pathology)

  7. Division of Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC, 20306, USA

    L. H. Sobin (Professor of Pathology) (Professor of Pathology)

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© 1995 International Union Against Cancer, Geneva

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Fyles, A., Kirkbride, P. (1995). Cervix Uteri Carcinoma. In: Hermanek, P., Gospodarowicz, M.K., Henson, D.E., Hutter, R.V.P., Sobin, L.H. (eds) Prognostic Factors in Cancer. UICC International Union Against Cancer / Union Internationale Contre le Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79395-0_20

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  • DOI: https://doi.org/10.1007/978-3-642-79395-0_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58688-3

  • Online ISBN: 978-3-642-79395-0

  • eBook Packages: Springer Book Archive

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