Cervix Uteri Carcinoma

  • A. Fyles
  • P. Kirkbride
Part of the UICC International Union Against Cancer / Union Internationale Contre le Cancer book series (UICCI)


Carcinoma of the cervix accounts for approximately one fifth of all gynecologic cancers and 2% of all malignancies in women. Numerous prognostic factors have been studied in patients with cervical carcinoma, using both univariate and multivariate analyses. Differences in end points of analysis, whether survival (disease-free or overall), relapse-free rate or local control rate, make comparisons of such studies difficult. Stage, histologic type and histologic grade are the commonly considered factors and have recently been joined by biologic factors including DNA ploidy, S-phase fraction and oncogene expression. Not all factors are relevant to all patients; for example, depth of tumor invasion and presence of vascular space invasion may only be reliably determined in patients treated with surgery, whereas hemoglobin level is important in patients treated with radiation. This review will concentrate largely on those factors identified using multivariate techniques, such as log rank or Cox regression analysis, in order to account for interactions between various factors and will present estimates such as hazard ratios, where available, in order to indicate the strengths of individual variables.


Cervical Cancer Human Papilloma Virus Cervical Carcinoma Uterine Cervix Figo Stage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© International Union Against Cancer, Geneva 1995

Authors and Affiliations

  • A. Fyles
  • P. Kirkbride

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