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Prognostic Factors in Cancer pp 152–164Cite as

Malignant Melanoma of Skin

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Abstract

This compilation of prognostic factors in malignant melanoma of the skin is predominantly based on the updated comprehensive overview on prognosis published in 1992 by Balch et al. [3, 4]. The authors’ data from the University of Erlangen, Germany (more than 850 patients) [26, 48, 49], and from the N.N. Petrov Research Institute of Oncology, St.Petersburg, Russia (614 patients) [53], are widely comparable with the data from the University of Alabama, Birmingham, USA, and the Sydney Melanoma Unit, Australia (over 8500 patients) [3], and are therefore not presented separately. In 1989, an analysis of 54 multivariate studies of melanoma was published by Vollmer [52]. The methodological differences and deficiencies of various studies and the importance of patient selection were discussed, especially with regard to different results. In Vollmer’s analysis of the literature, patients of different stages have been combined.

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References

  1. Baak JP, Tan GJ (1986) The adjuvant prognostic value of nuclear morphometry in stage I malignant melanoma of the skin: a multivariate analysis. Anal Quant Cytol Histol 8: 241–244

    PubMed  CAS  Google Scholar 

  2. Balch CM, Urist MM, Maddox WA, Soong S-J (1985) Melanoma in the Southern United States: experience at the University of Alabama in Birmingham. In: Balch CM, Milton GW (eds) Cutaneous melanoma. Lippincott, Philadelphia

    Google Scholar 

  3. Balch CM, Soong S-J, Shaw HM, Urist MM, McCarthy WH (1992) An analysis of prognostic factors in 8500 patients with cutaneous melanoma. In: Balch CM, Houghton AN, Milton GW, Sober AJ, Soong S-J (eds) Cutaneous melanoma, 2nd edn. Lippincott, Philadelphia

    Google Scholar 

  4. Balch CM, Cascinelli N, Drzewiecki KT, Eldh J, MacKie RM, McCarthy WH, McLeod GR, Morton DL, Seigier HF, Shaw HM, Sim FH, Sober AJ, Soong S-J, Takematsu H, Tonak J, Wong J (1992) A comparison of prognostic factors worldwide. In: Balch CM, Houghton AN, Milton GW, Sober AJ, Soong S-J (eds) Cutaneous melanoma, 2nd edn. Lippincott, Philadelphia

    Google Scholar 

  5. Balch CM, Milton GW, Cascinelli N, Sim FH (1992) Elective lymph node dissection. Pros and cons. In: Balch CM, Houghton AN, Milton GW, Sober AJ, Soong S-J (eds) Cutaneous melanoma, 2nd edn. Lippincott, Philadelphia

    Google Scholar 

  6. Calabro A, Singletary SE, Balch CM (1989) Patterns of relapse in 1001 consecutive patients with melanoma nodal metastases. Arch Surg 124: 1051–1055

    PubMed  CAS  Google Scholar 

  7. Cascinelli N, Nava M, Yaglini M, Maroida R, Santinami M, Rovini D, demente C (1985) Melanoma in Italy: experience at the National Cancer Institute of Milan. In: Balch CM, Milton GW (eds) Cutaneous melanoma. Lippincott, Philadelphia

    Google Scholar 

  8. Clark WH, Elder DE, Guerry D, Braitman LE, Trock BJ, Schultz D, Synnestvedt M, Halpern AC (1989) A model predicting survival in stage I melanoma based upon tumor progression. J Natl Cancer Inst 81: 1893–1904

    Article  PubMed  Google Scholar 

  9. Cochran AJ, Lana AM A, Wen D-R (1989) Histomorphometry in the assessment of prognosis in stage II malignant melanoma. Am J Surg Pathol 13: 600–604

    Article  PubMed  CAS  Google Scholar 

  10. Cox EB, Vollmer RT, Seigler HF (1985) Melanoma in the Southeastern United States: experi¬ence at the Duke Medical Center. In: Balch CM, Milton GW (eds) Cutaneous melanoma. Lippincott, Philadelphia

    Google Scholar 

  11. Day CL Jr, Sober AJ, Kopf AW, Lew RA, Mihm MC Jr, Golomb FM, Postel A, Hennessey P, Harris MN, Gumport SL, Raker JW, Malt RA, Cosimi AB, Wood WC, Roses DF, Gorstein F, Fitzpatrick TB, Postel A (1981) A prognostic model for clinical stage I melanoma of the lower extremity. Surgery 89: 599–603

    PubMed  Google Scholar 

  12. Day CL Jr, Sober AJ, Kopf AW, Lew RA, Mihm MC Jr, Golomb FM, Postel A, Hennessey P, Harris MN, Gumport SL, Raker JW, Malt RA, Cosimi AB, Wood WC, Roses DF, Gorstein F, Fitzpatrick TB, Postel A (1981) A prognostic model for clinical stage I melanoma of the trunk: location near the midline is not an independent risk factor for recurrent disease. Am J Surg 142: 247–251

    Article  PubMed  Google Scholar 

  13. Day CL Jr, Harrist TJ, Gorstein F, Sober AJ, Lew RA, Friedman RJ, Pasternack BS, Kopf AW, Fitzpatrick TB, Mihm MC Jr (1981) Malignant melanoma: prognostic significance of micro¬scopic satellites in the reticular dermis and subcutaneous fat. Ann Surg 194: 108–112

    Article  PubMed  Google Scholar 

  14. Day CL Jr, Harrist TJ, Lew RA, Mihm MC Jr (1982) Classification of malignant melanomas according to the histologic morphology of melanoma nodules. J Dermatol Surg Oncol 8: 874–890

    PubMed  Google Scholar 

  15. Drepper H, Biess B, Hofherr B, Hundeiker M, Lippold A, Otto F, Padberg G, Peters A, Wiebelt H (1992) The prognosis of patients with stage III melanoma. Prospective long-term study on 286 patients of the Fachklinik Hornheide. Cancer 71: 1239–1246

    Article  Google Scholar 

  16. Drepper H, Köhler CO, Bastian B, Breuninger H, Bröcker E-B, Göhl J, Groth W, Hermanek P, Hohenberger W, Lippold A, Kölmel K, Landthaler M, Peters A, Tilgen W (1993) Benefit of elective lymph node dissection in subgroups of melanoma patients. Cancer 72: 741–749

    Article  PubMed  CAS  Google Scholar 

  17. Drzewiecki KT, Andersen PK (1982) Survival with malignant melanoma. A regression analysis of prognostic factors. Cancer 49: 2414–2419

    Google Scholar 

  18. Drzewiecki KT, Poulsen H, Vibe P, Ladefoged C, Andersen PK (1985) Melanoma in Denmark: experience at the University Hospital, Odense. In: Balch CM, Milton GW (eds) Cutaneous melanoma. Lippincott, Philadelphia

    Google Scholar 

  19. Elder DE, Murphy GF (1991) Melanocytic tumors of the skin. Atlas of tumor pathology, 3rd series, fascicle 2. AfiP, Washington DC

    Google Scholar 

  20. Eldh J, Boeryd B, Peterson LE (1978) Prognostic factors in cutaneous malignant melanoma in stage I. A clinical, morphological and multivariate analysis. Scand J Plast Reconstr Surg 12: 243–255

    Google Scholar 

  21. Eldh J, Boeryd B, Suurküla M, Peterson LE, Holmström H (1985) Melanoma in Sweden: experience at the University of Göteborg. In: Balch CM, Milton GE (eds) Cutaneous melanoma. Lippincott, Philadelphia

    Google Scholar 

  22. Garbe C, Büttner P, Bertz J, Burg G, d’Hoedt B, Drepper H, Guggenmoos-Holzmann I, Lechner W, Lippold A, Orfanos CE, Peters A, Rassner G, Schwermann M, Stadler R, Stroebel W (1990) Die Prognose des primären malignen Melanoms. Eine multizentrische Studie an 5093 Patienten. In: Orfanos CE, Garbe C (eds) Das maligne Melanom der Haut. Zuckschwerdt, Munich

    Google Scholar 

  23. Hacene K, Le Doussal V, Brunet M, Lemoine F, Guerin P, Hebert H (1983) Prognostic index for clinical stage I cutaneous malignant melanoma. Cancer Res 43: 2991–2996

    PubMed  CAS  Google Scholar 

  24. Häffner AC, Garbe C, Burg G, Büttner P, Orfano CE, Rassner G (1992) The prognosis of primary and metastasising melanoma. An evaluation of the TNM classification in 2,495 patients. Br J Cancer 66: 856–861

    Article  PubMed  Google Scholar 

  25. Hermanek P, Sobin LH (eds) (1992) UICC TNM classification of malignant tumours, 4th edn, 2nd rev. Springer, Berlin Heidelberg New York

    Google Scholar 

  26. Hohenberger W, Göhl J, Kessler C (1993) Prophylaktische und therapeutische Lymphknoten¬dissektion bei malignem Melanom. Chirurg 32: 7–9

    Google Scholar 

  27. Kheir SA, Bines SD, Vonroenn JH, Soong S-J, Urist MM, Coon JS (1988) Prognostic significance of DNA aneuploidy in stage I cutaneous melanoma. Ann Surg 207: 455–461

    Article  PubMed  CAS  Google Scholar 

  28. Kopf AW, Gross DF, Rogers DS, Rigel DS, Hellman LJ, Levenstein M, Welkovich B, Friedman RJ, Roses DF, Bart RS, Mintzis MM, Gumport SL (1987) Prognostic index for malignant melanoma. Cancer 59: 1236–1241

    Article  PubMed  CAS  Google Scholar 

  29. Kopf AW, Welkovich B, Frankel RE, Stoppelmann EJ, Bart RS, Rogers GS, Rigel DS, Friedman RJ, Levenstein MJ, Gumport SL, Hennessey P (1987) Thickness of malignant melanoma: global analysis of related factors. J Dermatol Surg Oncol 13: 345–420

    PubMed  CAS  Google Scholar 

  30. McCarthy WH, Shaw HM, Milton GW, McGovern VJ (1985) Melanoma in New South Wales, Australia: experience at the Sydney Melanoma Unit. In: Balch CM, Milton GW (eds) Cutaneous melanoma. Lippincott, Philadelphia

    Google Scholar 

  31. Merkel DE, McGuire WL (1990) Ploidy, proliferative activity and prognosis. DNA flow cytometry of solid tumors. Cancer 65: 1194–1205

    Google Scholar 

  32. Meyskens FL Jr, Berdeaux DH, Parks B, Tong T, Loescher LS, Moon TE (1988) Cutaneous malignant melanoma ( Arizona Cancer Center experience ). Cancer 62: 1207–1214

    Google Scholar 

  33. Morton DL, Roe DJ, Cochran AJ (1985) Melanoma in the Western United States: experience with stage II melanoma at the UCLA Medical Center. In: Balch CM, Milton GW (eds) Cutaneous melanoma. Lippincott, Philadelphia

    Google Scholar 

  34. Morton DL, Davtyan DG, Wanek LA, Foshag LJ, Cochran AJ (1993) Multivariate analysis of the relationship between survival and the microstage of primary melanoma by Clark level and Breslow thickness. Cancer 71: 3737–3743

    Article  PubMed  CAS  Google Scholar 

  35. Presant CA, Bartolucci AA, Southeastern Cancer Study Group (1982) Prognostic factors in metastatic malignant melanoma. Cancer 49: 2192–2196

    Article  Google Scholar 

  36. Ronan SG, Eng AM, Briele HA, Shioura NN, Gupta TK (1987) Thin malignant melanomas with regression and metastases. Arch Dermatol 123: 1326–1330

    Article  PubMed  CAS  Google Scholar 

  37. Ronan SG, Han MC, Das Gupta TK (1988) Histologic prognostic indicators in cutaneous malignant melanoma. Semin Oncol 15: 558–565

    PubMed  CAS  Google Scholar 

  38. Schmoeckel C, Bockelbrink A, Bockelbrink H, Koutsis J, Braun-Falco O (1983) Low- and high- risk malignant melanoma. I. Evaluation of clinical and histological prognostic factors in 585 cases. Eur J Cancer Clin Oncol 19: 227–236

    Article  PubMed  CAS  Google Scholar 

  39. Schmoeckel C, Bockelbrink A, Bockelbrink H, Braun-Falco O (1983) Low- and high-risk malignant melanoma. II. Multivariate analyses for a prognostic classification. Eur J Cancer Clin Oncol 19: 237–243

    Google Scholar 

  40. Singletary SE, Tucker SL, Boddie AW (1988) Multivariate analysis of prognostic factors in regional cutaneous metastases of extremity melanoma. Cancer 61: 1437–1440

    Article  PubMed  CAS  Google Scholar 

  41. Singletary SE, Balch CM (1992) Recurrent regional metastases and their management. In: Balch CM, Houghton AN, Milton GW, Sober AJ, Soong S-J (eds) Cutaneous melanoma, 2nd edn. Lippincott, Philadelphia

    Google Scholar 

  42. Sirott MN, Bajorin DF, Wong GYC, Tao Y, Chapman PB, Templeton MA, Houghton A (1993) Prognostic factors in patients with metastatic malignant melanoma. Cancer 72: 3091–3098

    Article  PubMed  CAS  Google Scholar 

  43. Sober AJ, Day CL Jr, Koh HK, Lew RA, Mihm MC Jr, Kopf AW, Fitzpatrick TP (1985) Melanoma in the Northeastern United States: experience of the Melanoma Clinical Cooperative Group. In: Balch CM, Milton GW (eds) Cutaneous melanoma. Lippincott,Philadelphia

    Google Scholar 

  44. Sondergaard K, Schou G (1985) Therapeutic and clinico-pathological factors in the survival of 1,469 patients with primary cutaneous malignant melanoma in clinical stage I. Virchows Arch [A] 408: 249–258

    Article  CAS  Google Scholar 

  45. Soong S-J (1985) A computerized mathematical model and scoring system for predicting outcome in melanoma patients. In: Balch CM, Milton GW (eds) Cutaneous melanoma. Lippincott, Philadelphia

    Google Scholar 

  46. Soong S-J (1992) A computerized mathematical model and scoring system for predicting outcome in patients with localized melanoma. In: Balch CM, Houghton AN, Milton GW, Sober AJ, Soong S-J (eds) Cutaneous melanoma, 2nd edn. Lippincott, Philadelphia

    Google Scholar 

  47. Timmons MJ, Thomas JM (1993) The width of excision of cutaneous melanoma. Eur J Surg Oncol 19: 313–315

    PubMed  CAS  Google Scholar 

  48. Tonak J, Hermanek P, Weidner F, Guggenmoos-Holzmann I, Altendorf A (1985) Melanoma in Germany: experience at the University of Erlangen-Nürnberg. In: Balch CM, Milton GW (eds) Cutaneous melanoma. Lippincott, Philadelphia

    Google Scholar 

  49. Tonak J (1986) Malignes Melanom der Haut. In: Gall FP, Hermanek P, Tonak J (eds) Chirurgische Onkologie. Springer, Berlin Heidelberg New York

    Google Scholar 

  50. Urist MM, Balch CM, Soong S-J, Milton GW, Shaw HM, McGovern VJ, Murad TM, McCarthy WH, Maddox WA (1984) Head and neck melanoma in 536 clinical stage I patients. Ann Surg 200: 769–775

    Article  PubMed  CAS  Google Scholar 

  51. Van der Esch EP, Cascinelli N, Preda F, Morabito A, Bufalino R (1981) Stage I melanoma of the skin: evaluation of prognosis according to histologic characteristics. Cancer 48: 1668–1673

    Article  Google Scholar 

  52. Vollmer RT (1989) Malignant melanoma. A multivariate analysis of prognostic factors. Pathol Annu 24: 383–407

    PubMed  Google Scholar 

  53. Wagner RI, Blinov NN, Anisimov W (1987) Clinical diagnostic and prognosis of primary malignant skin melanoma. In: Actual problems of diagnostic and treatment of malignant skin melanoma. Research Works of the Petrov Research Institute of Oncology, Leningrad

    Google Scholar 

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Authors
  1. P. Hermanek
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  2. N. N. Blinov
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Editor information

Editors and Affiliations

  1. Chirurgische Universitätsklinik Erlangen, Krankenhausstr. 12, 91054, Erlangen, Germany

    P. Hermanek (Vorstand der Abteilung für Klinische Pathologie i. R.) (Vorstand der Abteilung für Klinische Pathologie i. R.)

  2. Princess Margaret Hospital, Department of Radiation Oncology, University of Toronto, 500 Sherbourne Street, Toronto, Ontario, M4X 1K9, Canada

    Mary K. Gospodarowicz

  3. Early Detection Branch, Division of Cancer Prevention and Control, National Cancer Institute, EPN Building, Room 305 9000 Rockville Pike, Bethesda, MD, 20892, USA

    D. E. Henson

  4. University of Medicine and Dentistry, New Jersey Medical School, Newark, NJ, USA

    R. V. P. Hutter (Clinical Professor of Pathology) (Clinical Professor of Pathology)

  5. Department of Pathology, Saint Barnabas Medical Center, Old Short Hills Road, Livingston, NJ, 07039, USA

    R. V. P. Hutter (Clinical Professor of Pathology) (Clinical Professor of Pathology)

  6. Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    L. H. Sobin (Professor of Pathology) (Professor of Pathology)

  7. Division of Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC, 20306, USA

    L. H. Sobin (Professor of Pathology) (Professor of Pathology)

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© 1995 International Union Against Cancer, Geneva

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Hermanek, P., Blinov, N.N. (1995). Malignant Melanoma of Skin. In: Hermanek, P., Gospodarowicz, M.K., Henson, D.E., Hutter, R.V.P., Sobin, L.H. (eds) Prognostic Factors in Cancer. UICC International Union Against Cancer / Union Internationale Contre le Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79395-0_17

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  • DOI: https://doi.org/10.1007/978-3-642-79395-0_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58688-3

  • Online ISBN: 978-3-642-79395-0

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