Carcinoma of the Extrahepatic Bile Ducts

  • M. T. Carriaga
  • D. E. Henson
Part of the UICC International Union Against Cancer / Union Internationale Contre le Cancer book series (UICCI)


Compared to carcinomas of the gallbladder, carcinomas of the extrahepatic bile ducts are less common, occur more often in men than in women, are usually not associated with lithiasis, and have a different epidemiologic distribution [1–3, 7, 12]. The prognosis for extrahepatic bile duct carcinomas is very poor, with an overall 5-year survival rate of only about 12%. Herein we describe the results of our analysis of the prognostic factors for carcinomas of the extrahepatic bile ducts. This analysis is based primarily on published reports on the prognostic factors in cancers of the extrahepatic bile ducts, including data from the Surveil­lance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute. No multivariate analysis has been reported on combinations of the different prognostic factors.


Adenocarcinoma Anemia Cholangiocarcinoma 


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  1. 1.
    Albores-Saavedra J, Henson DE (1986) Tumors of the gallbladder and extrahepatic bile ducts. Armed Forces Institute of Pathology, Washington DCGoogle Scholar
  2. 2.
    Alexander F, Rossi RL, O’Bryan M, Khettry V, Braasch JW, Watkins E (1984) Biliary carcinoma: a review of 109 cases. Am J Surg 147: 503–509PubMedCrossRefGoogle Scholar
  3. 3.
    Anderson JB, Cooper MJ, Williamson RCN (1985) Adenocarcinoma of the extrahepatic biliary tree. Ann Roy Coll Surg Engl 67: 139–143Google Scholar
  4. 4.
    Carriaga MT, Henson DE (1995) Liver, gallbladder, extrahepatic bile ducts, and pancreas: incidence and prognosis by histologic type. SEER population-based data, 1973–1987. Cancer (in press)Google Scholar
  5. 5.
    Chao TC, Greager JA (1991) Carcinoma of the extrahepatic bile ducts. J Surg Oncol 46: 145–150PubMedCrossRefGoogle Scholar
  6. 6.
    Fortner JG, Vitelli CE, MacLean BJ (1989) Proximal extrahepatic bile duct tumors: analysis of a series of 52 consecutive patients treated over a period of 13 years. Arch Surg 124: 1275–1279PubMedGoogle Scholar
  7. 7.
    Henson DE, Albores-Saavedra J, Corle D (1992) Carcinoma of the extrahepatic bile ducts. Cancer 70: 1498–1501PubMedCrossRefGoogle Scholar
  8. 8.
    Kozuka S, Tsuborne M, Hachisuka K (1984) Evolution of carcinoma in the extrahepatic bile ducts. Cancer 54: 65–72PubMedCrossRefGoogle Scholar
  9. 9.
    Nakajima T, Kondo Y (1989) Well differentiated cholangiocarcinoma: diagnostic significance of morphologic and immunohistochemical parameters. Am J Surg Pathol 13: 569–573PubMedCrossRefGoogle Scholar
  10. 10.
    Ouchi K, Suzuki M, Hashimoto L, Sato T (1989) Histologic findings and prognostic factors in carcinoma of the upper bile duct. Am J Surg 157: 552–556PubMedCrossRefGoogle Scholar
  11. 11.
    Reding R, Buard JL, Lebeau G, Saunois B (1991) Surgical management of 552 carcinomas of the extrahepatic bile ducts (gallbladder and periampullary tumors excluded): results of the French Surgical Association Survey. Ann Surg 213: 236–241PubMedCrossRefGoogle Scholar
  12. 12.
    Strom BL, Hibberd PL, Soper KA, Stolley PD, Nelson WL (1985) International variations in epidemiology of cancers of the extrahepatic biliary tract. Cancer Res 45: 5165–5168PubMedGoogle Scholar
  13. 13.
    Todoroki T, Okamura T, Fukao K et al (1980) Gross appearance of carcinoma of the main hepatic duct and its prognosis. Surg Gynecol Obstet 150: 33–40PubMedGoogle Scholar
  14. 14.
    Tompkins RK, Saunders K, Roslyn J J, Longmire WP Jr (1990) Changing patterns in diagnosis and management of bile duct cancer. Ann Surg 211: 614–620PubMedGoogle Scholar
  15. 15.
    Tompkins RK, Thomas D, Wile A, Longmire WP (1981) Prognostic factors in bile duct carcinoma: analysis of 96 cases. Ann Surg 194: 447–457PubMedCrossRefGoogle Scholar
  16. 16.
    Tsuzuki T, Ueda M, Kuramochi S, Iida S, Takahashi S, Iri H (1990) Carcinoma of the main hepatic duct junction: indications, operative morbidity and mortality, and long-term survival. Surg 108: 495–501Google Scholar
  17. 17.
    Yamaguchi K, Enjoji M, Nakayama F (1988) Cancer of the extrahepatic bile duct: a clinico- pathologic study of immunohistochemistry for CEA, CA 19–9, and p21. World J Surg 12: 11–17PubMedCrossRefGoogle Scholar

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© International Union Against Cancer, Geneva 1995

Authors and Affiliations

  • M. T. Carriaga
  • D. E. Henson

There are no affiliations available

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