Summary
Epithelial cells lining some kidney tubule segments have developed highly–specialized, yet independent systems for the rapid modulation their plasma membrane composition in response to different stimuli. In all cases, this process involves the movement of intracellular transporting vesicles that carry specific protein cargoes to and from the plasma membrane. These vesicles have transport features that differ among the various cell types, and this brief review will examine endosomes from the proximal tubule, and collecting duct intercalated principal cells, with respect to their content of two important proteins: water channels and proton pumps (H+ATPase). The endosomal content of these two proteins varies in relation to the physiological role of the epithelial cell types. Apical endosomes from the proximal tubule contain both proteins, intercalated cell endosomes contain proton pumps but not water channels, and principal cell apical endosomes contain water channels but lack functional proton pumps. This endosomal division of labour along the urinary tubule is summarized in Figure 1 and has been revealed using a combination of morphological, immunocytochemical and functional techniques.
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© 1994 Springer-Verlag Berlin Heidelberg
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Brown, D., Sabolić, I. (1994). Acidic and non-acidic endosomes in kidney epithelial cells: their role in cell-specific membrane recycling processes. In: Hirst, B.H. (eds) Molecular and Cellular Mechanisms of H+ Transport. NATO ASI Series, vol 89. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79301-1_15
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DOI: https://doi.org/10.1007/978-3-642-79301-1_15
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