Reproductive Potential After Adjuvant Chemotherapy for Breast Cancer

  • P. Valagussa
  • D. De Candis
  • G. Antonelli
  • G. Bonadonna
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 140)

Abstract

The 10-year update of the world-wide overview of breast cancer treatment (Early Breast Cancer Trialists’ Collaborative Group 1992) has confirmed that adjuvant systemic therapy can alter the course of breast cancer. In women younger than 50 years of age (i.e. in premenopausal women), highly significant reductions in the annual rates of both recurrence (37%) and death (27%) are produced by adjuvant combination chemotherapy when compared with local-regional treatment alone.

Keywords

Estrogen Leukemia Methotrexate Cyclophosphamide Anthracyclines 

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References

  1. Bonadonna G (1992) Evolving concepts in the systemic adjuvant treatment of breast cancer. Cancer Res 52: 2127–2137PubMedGoogle Scholar
  2. Boring CC, Squires TS, Tong T (1993) Cancer statistics, 1993. CA 43: 7–26PubMedGoogle Scholar
  3. Danforth DN (1991) How subsequent pregnancy affects outcome in women with a prior breast cancer. Oncology 5: 23–32PubMedGoogle Scholar
  4. Donegan WL (1977) Pregnancy and breast cancer. Obstet Gynecol 50: 244–251PubMedGoogle Scholar
  5. Dow KH, Harris JR, Roy C (1994) Pregnancy after breast-conserving surgery and radiation therapy for breast cancer. Monogr Natl Cancer Inst 16: 131–137PubMedGoogle Scholar
  6. Early Breast Cancer Trialists' Collaborative Group (1992) Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. 133 randomised trials involving 31000 recurrences and 24 000 deaths among 75 000 women. Lancet 339:1–15, 71–85Google Scholar
  7. Mulvihill JJ, McKeen EA, Rosner F, Zarrabi MH (1987) Pregnancy outcome in cancer patients. Experience in a large cooperative group. Cancer 60: 1143–1150Google Scholar
  8. Myers SE, Schilsky RL (1992) Prospects for fertility after cancer chemotherapy. Semin Oncol 19: 597–604PubMedGoogle Scholar
  9. Reichman BS, Green KB (1994) Breast cancer in young women: effect of chemotherapy on ovarian function, fertility, and birth defects. Monogr Natl Cancer Inst 16: 125–129PubMedGoogle Scholar
  10. Sutton R, Buzdar AU, Hortobagyi GN (1990) Pregnancy and offspring after adjuvant chemotherapy in breast cancer patients. Cancer 65: 847–850PubMedCrossRefGoogle Scholar
  11. Valagussa P, Moliterni A, Zambetti M, Bonadonna G (1993) Long-term sequelae from adjuvant chemotherapy. Recent Res Cancer Res 127: 247–255CrossRefGoogle Scholar
  12. Ventura SJ (1989) First births to older mothers 1970–1986. Am J Public Health 79: 1675–1684PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • P. Valagussa
    • 1
  • D. De Candis
    • 1
  • G. Antonelli
    • 1
  • G. Bonadonna
    • 1
  1. 1.Division of Medical OncologyIstituto Nazionale TumoriMilanoItaly

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