Abstract
Primary chemotherapy, in combination with radiotherapy and/or surgery, has been used in the treatment of advanced carcinoma of the breast for several decades. The term often used for this type of treatment is “neoadjuvant chemotherapy.” More recently, less advanced cases of breast carcinoma have been treated by primary chemotherapy and many studies have been published describing optimistic results; however, very few randomized controlled investigations have appeared, and questions such as: “Should surgery remain the initial treatment of ‘operable’ breast cancer?” remain (Kurtz 1991).
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References
Bélembaogo E, Feillel V, Chollet P et al. (1992) Neoadjuvant chemotherapy in 126 operable breast cancers. Eur J Cancer 28A: 896–900
Bonadonna G, Veronesi U, Brambilla C et al. (1990) Primary chemotherapy to avoid mastectomy in tumors with diameters of three centimeters or more. J Natl Cancer Inst 82: 1539–1545
Brun B, Poitevin A, Kassem M et al. (1993) High dose ambulatory neoadjuvant chemotherapy in poor prognosis breast cancer patients. Proc ASCO 12: 87
Calais G, Berger C, Descamps P et al. (1994) Conservative treatment feasibility with induction chemotherapy, surgery, and radiotherapy for patients with breast carcinoma larger than 3cm. Cancer 74: 1283–1288
Fisher B, Rockette H, Robidoux A et al. (1994) Effect of preoperative therapy of breast cancer (BC) on local-regional disease: first report of NSABP B-18. Proc ASCO 13: 64
Flores MR, Morrell L, Richman S etal. (1993) Neoadjuvant methotrexate, vinblastine, doxorubicin and cisplatin (MVAC) for locally advanced breast cancer ( LABC ). Proc ASCO 12: 102
Jacquillat C, Weil M, Baillet F et aI. (1990) Results of neoadjuvant chemotherapy and radiation therapy in the breast-conserving treatment of 250 patients with all stages of infiltrative breast cancer. Cancer 66: 119–129
Kurtz JM (1991) Should surgery remain the initial treatment of “operable” breast cancer, Eur J Cancer 27: 1539–1542
Mauriac L, Durand M, Avril A, Dihuydy J-M (1991) Effects of primary chemotherapy in conservative treatment of breast cancer patients with operable tumors larger than 3cm. Ann Oncol 2: 347–354
Papaioannou AN (1985) Preoperative chemotherapy: advantages and clinical application in stage III breast cancer. In: Metzger U, Largiadér F, Senn HJ (eds) Perioperative chemotherapy. Rationale, risk and results. Springer, Bertin Heidelbary New York, pp 65–90 (Recent results in cancer research, vol 98 )
Ragaz J, Baird R, Rebbeck R, Goldie A, Coldman A, Spinelli J (1985) Preoperative adjuvant chemotherapy (neoadjuvant) for carcinoma of the breast: rationale and safety report. In: Metzger U, Largiadér F, Senn HJ (eds) Perioperative chemotherapy. Rationale, risk and results. Springer, Bertin Heidelbery New York, pp 99–105 (Recent results in cancer research, vol 98 )
Ragaz J, Manji M, Plenderleith IH et al. (1994) Impact of the residual disease in stage III breast cancer patients treated with preoperative (neoadjuvant) chemotherapy (CT), radiotherapy (XRT) and mastectomy. The 10 year analysis of the British Columbia study. Proc ASCO 13: 71
Schabel FM (1985) Rationale for perioperative anticancer treatment. In: Metzger U, Largiadér F, Senn HJ (eds) Perioperative chemotherapy. Rationale, risk and results. Springer, Bertin Heidelbery New York, pp 1–10 (Recent results in cancer research, vol 98 )
Scholl SM, Fourquet A, Asselain B et al. (1994) Neoadjuvant versus adjuvant chemotherapy in premenopausal patients with tumours considered too large for breast conserving surgery: preliminary results of a randomised trial: S6. Eur J Cancer 30A: 645–652
Schwartz GF, Birchansky CA, Komarnicky LT et al. (1994) Induction chemotherapy followed by breast conservation for locally advanced carcinoma of the breast. Cancer 73: 362–369
Singletary SE, McNeese MD, Hortobagyi GN (1992) Feasibility of breast-conservation surgery after induction chemotherapy for locally advanced breast carcinoma. Cancer 69: 2849–2852
Singletary SE, Ames FC, Buzdar AU (1994) Management of inflammatory breast cancer. World J Surg 18: 87–92
Smith IE, Jones AL, Prendiville J, Walsh G (1994) Primary continuous infusional chemotherapy as an alternative to mastectomy or any surgery for large operable breast cancer. Proc ASCO 13: 69
Valagussa P, Zambetti M, Bonadonna G, Zucali R, Mezzanotte G, Veronesi U (1990) Prognostic factors in locally advanced noninflammatory breast cancer. Long-term results following primary chemotherapy. Breast Cancer Res Treatment 15: 137–147
Van Praagh I, Feillel V, Cure H et al. (1995) Neoadjuvant NEM chemotherapy regimen for operable breast cancer: results of a co-operative study on 59 patients. 5th international congress on anti-cancer chemotherapy, Paris, 0531
Zurrida S, Greco M, Veronesi U (1994) Surgical pitfalls after preoperative chemotherapy in large size breast cancer. Eur J Surg Onc 20: 641–643
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Rudenstam, CM. (1996). The Primary Use of Chemotherapy for Operable Breast Cancer: Does Systemic Therapy Make Surgery Superfluous?. In: Senn, H.J., Gelber, R.D., Goldhirsch, A., Thürlimann, B. (eds) Adjuvant Therapy of Breast Cancer V. Recent Results in Cancer Research, vol 140. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79278-6_20
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DOI: https://doi.org/10.1007/978-3-642-79278-6_20
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