Abstract
Multiple myeloma is a malignancy of plasma cells. Patients with myeloma have associated immune deficiencies, including decreased numbers of B cells in the peripheral blood and corresponding decreased humoral responses. Myeloma patients also show significant alterations in T cell function. There are decreased numbers of CD4+ T cells while CD8+ T cells are normal to slightly increased [1,2].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Hoover RG, Kombluth J (1992) Immunoregulation of murine and human myeloma. Hematology/Oncology Clinics of North America 6: 407–424.
San Miguel JF et al (1992) Lymphoid subsets and prognostic factors in multiple myeloma. Br J Haematol 80: 305–309.
Linsley PS, Ledbetter PS (1993) The role of the CD28 receptor during T cell responses to antigen. Ann Rev Immunol 11: 191–212.
Harding FA, McArthur JG, Gross JA, Raulet DH, Allison JP (1992) CD28-mediated signalling costimulates murine T cells and prevents induction of anergy in T cell clones. Nature 356: 607–609.
Hansen JA, Martin PJ, Nowinski RC (1980) Monoclonal antibodies identifying a novel T cell antigen of human lymphocytes. Immunogenetics 10: 247–260.
Hara T, Fu SM, Hansen JA (1985) A new activation pathway used by a major T cell population via a disulfide-bonded dimer of a 44 kilodalton polypeptide (9.3 antigen). J Exp Med 161: 1513–1524.
Kozbor D, Moretta A, Messner HA, Moretta L, Croce CM (1987) Tp44 molecules involved in antigen-independent T cell activation are expressed on human plasma cells. J Immunol 138: 4128–4132.
Linsley PS, Brady W, Grosmaire L, Aruffo A, Damle NK, Ledbetter JA (1991) Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J Exp Med 173: 721–730.
Freeman GJ et al (1993) Uncovering of functional alternative CTLA-4 counter-receptor in B7-deficient mice. Science 262: 907–909.
Boussiotis VA, Freeman GJ, Gribben JG, Daley J, Gray G, Nadler LM (1993) Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T cell activation. Proc Natl Acad Sci USA 90: 11059–11063.
Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 174: 561–569.
Azuma M, Yssel H, Phillips JH, Spits H, Lanier LL (1993) Functional expression of B7/BB1 on activated T lymphocytes. J Exp Med 177: 845–850.
Yokochi T, Holly RD, Clark EA (1982) B lymphoblastoid antigen (BB-1) expressed on Epstein-Barr virus activated B cell blasts, B lymphoid lines, and Burkitt’s lymphomas. J Immunol 128: 823–827.
Hata H, Xiao HQ, Petrucci MT, Woodliff, Epstein J (1993) Interleukin-6 gene expression in multiple myeloma: a characteristic of immature tumor cells. Blood 81: 3357–3364.
Kornbluth J, Spear B, Raab SS, Wilson DB (1985) Evidence for the role of class I and class II HLA antigens in the lytic function of a cloned line of human natural killer cells. J Immunol 134: 728–735.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Kornbluth, J. (1995). Potential Role of CD28-B7 Interactions in the Growth of Myeloma Plasma Cells. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1994. Current Topics in Microbiology and Immunology, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79275-5_6
Download citation
DOI: https://doi.org/10.1007/978-3-642-79275-5_6
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-79277-9
Online ISBN: 978-3-642-79275-5
eBook Packages: Springer Book Archive