Skip to main content
SpringerLink
Log in
Book cover

Mechanisms in B-Cell Neoplasia 1994 pp 341–346Cite as

Mantle Cell/Centrocytic Lymphoma: Molecular and Phenotypic Analysis Including Analysis of the bcl-1 Major Translocation Cluster by PCR

  • Chapter

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 194))

Abstract

Mantle cell/centrocytic lymphoma (MCL) is a biologically and clinically distinct subtype of non-Hodgkin’s lymphoma (NHL) characterized by small lymphocytes with irregular nuclei and a diffuse, vaguely nodular, or mantle zone growth pattern [1, 2]. The neoplastic cells are typically positive for CD5, the pan-B cell antigens CD19 and CD20, and surface IgM and IgD, but negative for CD10 and CD23. Clinical features include male predominance, a median age of onset of 64 years, and presentation with advanced stage disease in the majority of patients. Peripheral blood, bone marrow, and extranodal disease involving the gastrointestinal tract or Waldeyer’s ring is common [1, 2]. The median survival is approximately 30–40 months. MCL is estimated to comprise about 4–7% of all NHL.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Swerdlow SH, Williams HE (1993) Centrocytic lymphoma: A distinct clinicopathologic, immunophenotypic, and genotypic entity. Pathol Annual 28: 171–197

    Google Scholar 

  2. Zucca E, Stein H, Coiffier B (1994) European Lymphoma Task Force (ELTF): Report of the workshop on mantle cell lymphoma (HCL). Annals Oncol, in press

    Google Scholar 

  3. Williams HE, Westermann CD, Swerdlow SH (1990) Genotypic characterization of centrocytic lymphoma: Frequent rearrangement of the chromosome 11 bcl-1 locus. Blood 76: 1387–1391

    PubMed  CAS  Google Scholar 

  4. Williams HE, Heeker TC, Swerdlow SH (1991) Rearrangement of the chromosome 11 bcl-1 locus in centrocytic lymphoma: Analysis with multiple breakpoint probes. Blood 78: 493–498

    PubMed  CAS  Google Scholar 

  5. Rimokh R, Berger F, Cornillet P, Wahbi K, Rouault JP, Ffrench H, Bryon PA, Gadoux H, Gentilhomme O, Germain D, Hagaud JP (1990) Break in the bell locus is closely associated with intermediate lymphocytic lymphoma subtype. Genes, Chromosomes and Cancer 2: 223–226

    CAS  Google Scholar 

  6. Hedeiros LJ, Van Krieken JH, Jaffe ES, Raffeid H (1990) Association of bcl-1 rearrangements with lymphocytic lymphoma of intermediate differentiation. Blood 76: 2086–2090

    Google Scholar 

  7. Williams ME, Swerdlow SH, Rosenberg CL, Arnold A (1992) Characterization of chromosome 11 translocation breakpoints at the bcl-1 and PRAD1 loci in centrocytic lymphoma. Cancer Res 52: 5541s–5544s

    PubMed  CAS  Google Scholar 

  8. Rosenberg CL, Wong E, Petty EM, Bale AE, Tsujimoto Y, Harris NL, Arnold A (1991) PRAD1, a candidate BCll oncogene: Mapping and expression in centrocytic lymphoma. Proc Natl Acad Sci USA 88: 9638–9642

    Article  PubMed  CAS  Google Scholar 

  9. Rimokh R, Berger F, Delsol G, Charrin C, Bertheas MF, Ffrench M, Garoscio M, Felman P, Coiffier B, Bryon PA, Rochet M, Gentilhomme O, Germain D, Magaud JP (1993) Rearrangement and overexpression of the bcl-l/PRAD-1 gene in intermediate lymphocytic lymphomas and in t(11ql3)-bearing leukemias. Blood 81: 3063–3067

    PubMed  CAS  Google Scholar 

  10. Raynaud S, Bekri S, Leroux D, Grosgeorge J, Klein B, Bastard C, Gaudray P, Simon MP (1993) Expanded range of 11q13 breakpoints with differing patterns of cyclin D1 expression in B-cell malignancies. Genes, Chromosomes and Cancer 8: 80–87

    Article  CAS  Google Scholar 

  11. Williams ME, Swerdlow SH (1994) Cyclin D1 overexpression in non-Hodgkin’s lymphoma with chromosome 11 bcl-1 rearrangement. Annals Oncol 5 (Suppl.1): S71–S73

    Google Scholar 

  12. Williams ME, Gaffey MJ, Weiss LM, Wilczynski C, Schuuring E, Levine P (1993) Chromosome 11q13 amplification in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 119: 1238–1243

    PubMed  CAS  Google Scholar 

  13. Gaffey MJ, Frierson HF, Williams ME (1993) Chromosome 11q13, c-erbB-2, and c-myc amplification in invasive breast carcinoma: Clinicopathologic correlations. Mod Path 6: 654–659

    CAS  Google Scholar 

  14. Sander CA, Yano T, Clark HM, Harris C, Longo DL, Jaffe ES, Raffeid M (1993) p53 mutation is associated with progression in follicular lymphomas. Blood 82: 1994–2004

    Google Scholar 

  15. LoCoco F, Gaidano G, Louie DC, Offit K, Chaganti RSK, Dalla-Favera R (1993) p53 mutations are associated with histologic transformation of follicular lymphoma. Blood 82: 2289–2295

    Google Scholar 

  16. deBoer CJ, Loyson S, Kluin PM, Kluin-Nelemans HC, Schuuring E, van Krieken JHJM (1993) Multiple breakpoints within the BCL-1 locus in B-cell lymphoma:Rearrangements of the cyclin D1 gene. Cancer Res 53: 4148–4152

    CAS  Google Scholar 

  17. Williams ME, Swerdlow SH, Meeker TC (1993) Chromosome t(11;14)(ql3;q32) breakpoints in centrocytic lymphomas are highly localized at the bcl-1 major translocation cluster. Leukemia 7: 1437–1440

    PubMed  CAS  Google Scholar 

  18. Raffeid M, Jaffe ES (1991) bcl-1, t(ll;14), and mantle cell-derived lymphomas. Blood 78:259–263

    Google Scholar 

  19. Jadayel D, Matutes E, Dyer MJS, Brito-Babapulle V, Khokar MT, Oscier D, Catovsky D (1994) Splenic lymphoma with villous lymphocytes: Analysis of bcl-1 rearrangements and expression of the cyclin D1 gene. Blood, in press

    Google Scholar 

  20. Fiedler W, Weh HJ, Hossfeld DK (1992) Comparison of chromosome analysis and bcl-1 rearrangement in a series of patients with multiple myeloma. Brit J Haematol 81: 58–61

    Article  CAS  Google Scholar 

  21. Seto M, Yamamoto K, Iida S, Akao Y, Utsumi KR, Kubonishi I, Miyoshi I, Ohtsuki T, Yawata Y, Namba M, Motokura T, Arnold A, Takahashi T, Ueda R (1992) Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(ql3;q32) translocation. Oncogene 7: 1401–1406

    PubMed  CAS  Google Scholar 

  22. Travis P, Sawyer J, Lary C, Hoover R, Barlogie B (1993) Translocation 11;14 and BCL-1 gene abnormalities in multiple myeloma. Blood 82 (Suppl.1): 261a

    Google Scholar 

  23. Williams ME, Swerdlow SH, Rosenberg CL, Arnold A (1993) Chromosome 11 translocation breakpoints at the PRADl/cyclin D1 gene locus in centrocytic lymphoma. Leukemia 7: 241–245.

    PubMed  CAS  Google Scholar 

  24. Rimokh R, Berger F, Delsol G, Digonnet I, Rouault JP, Tigaud JD, Gadoux M, Coiffier B, Bryon PA, Magaud JP (1994) Detection of the chromosomal translocation t(11;14) by polymerase chain reaction in mantle cell lymphomas. Blood 83: 1871–1875

    PubMed  CAS  Google Scholar 

  25. Molot RJ, Meeker TC, Wittwer CT, Perkins SL, Segal GH, Masih AS, Braylan RC, Kjeldsberg CR (1994) Antigen expression and polymerase chain reaction amplification of mantle cell lymphomas. Blood 83: 1626–1631

    PubMed  CAS  Google Scholar 

  26. Withers DA, Harvey RC, Faust JB, Melnyk O, Carey K, Meeker TC (1991) Characterization of a candidate bcl-1 gene. Mol Cell Biol 11: 4846–4853

    PubMed  CAS  Google Scholar 

  27. Yang WI, Zukerberg LR, Motokura T, Arnold A, Harris NL (1994) Pradl/Cyclin D1 (bcl-1) protein expression in low grade B-cell lymphomas and reactive hyperplasia. Am J Pathol, in press

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Internal Medicine and Pathology, University of Virginia School of Medicine, Charlottesville, VA, USA

    M. E. Williams

  2. Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    L. R. Zukerberg, N. L. Harris & W-I. Yang

  3. Endocrine Oncology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    L. R. Zukerberg & A. Arnold

  4. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    S. D. Finkelstein & S. H. Swerdlow

Authors
  1. M. E. Williams
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L. R. Zukerberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. L. Harris
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. W-I. Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Arnold
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. D. Finkelstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S. H. Swerdlow
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute National Institutes of Health, Bldg. 37, Rm. 2B04, 20892, Bethesda, MD, USA

    Michael Potter M.D. (Chief) (Chief)

  2. Institute for Immunology, Grenzacherstr. 487, CH-4005, Basel, Switzerland

    Fritz Melchers (Director) (Director)

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Williams, M.E. et al. (1995). Mantle Cell/Centrocytic Lymphoma: Molecular and Phenotypic Analysis Including Analysis of the bcl-1 Major Translocation Cluster by PCR. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1994. Current Topics in Microbiology and Immunology, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79275-5_39

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-79275-5_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79277-9

  • Online ISBN: 978-3-642-79275-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation