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Mechanisms in B-Cell Neoplasia 1994 pp 163–169Cite as

Tumorigenesis in Mice with an SV40 T Antigen Transgene Driven by the Immunoglobulin γ1 Heavy Chain Germline Promoter

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 194))

Abstract

The immunoglobulin heavy chain switch is a genetic recombination whereby a V(D)J region is rearranged from association with the Cµ gene to association with a downstream Cγ, Cε, or Cα gene [1,2). The recombination event occurs in switch (S) regions found upstream of each CH gene except Cδ. Switch recombination is preceded by a change in the “accessibility” of the switch region DNA, as indicated by the induction of transcription of the CH locus prior to switch recombination [1–4]. Both induction of germline transcripts and switch recombination of any CH locus are specifically regulated by cytokines.

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References

  1. Lutzker SG, Alt FW (1989) Immunoglobulin heavy chain class switching. In: Berg D E, Howe M (ed) Mobile DNA. American Society for Microbiology, Washington,D.C., pp 693–714

    Google Scholar 

  2. Esser C, Radbruch A (1990) Immunoglobulin class switching: molecular and cellular analysis. Ann Rev Immunol 8:717–735

    Article  CAS  Google Scholar 

  3. Stavnezer-Nordgren J, Sirlin S (1986) Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching. EMBO J 5: 95–102

    PubMed  CAS  Google Scholar 

  4. Yancoupoulos GD, DePinho RA, Zimmerman KA, Lutzker SG, Rosenberg N, Alt FW (1986) Secondary rearrangement events in pre-B cells: VHEXJH replacement by a LINE-1 sequence and directed class switching. EMBO J 5: 3259–3266

    Google Scholar 

  5. Adams JM, Cory S (1991) Transgenic models of tumor development. Science 254: 1661–1167

    Article  Google Scholar 

  6. van Lohuizen M, Berns A (1990) Tumorigenesis by slow-transforming retroviruses—an update. Biochim Biophys Acta 1032: 213–235

    PubMed  Google Scholar 

  7. Stavnezer J, Radcliffe G, Lin Y-C, Nietupski J, Berggren L, Sitia R, Severinson E (1988) Immunoglobulin heavy-chain switching may be directed by prior induction of transcripts from constant-region genes. Proc Natl Acad Sci USA 85: 7704–7708

    Article  PubMed  CAS  Google Scholar 

  8. Esser C, Radbruch A (1989) Rapid induction of transcription of unrearranged Syl switch regions in activated murine B cells by interleukin 4. EMBO J 8: 483–488

    PubMed  CAS  Google Scholar 

  9. Berton MT, Uhr JW, Vitetta ES (1989) Synthesis of germ-line γl immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon γ. Proc Natl Acad Sci USA 86: 2829–2833

    Article  PubMed  CAS  Google Scholar 

  10. Xu M, Stavnezer J (1990) Structure of germline immunoglobulin heavy- chain γl transcripts in interleukin 4 treated mouse spleen cells. Dev Immunol 1: 11–17

    Article  PubMed  CAS  Google Scholar 

  11. Huff JE, Haseman JK, Eustis S, Maronpot RR, Peters AC, Persing RL, Chrisp CE, Jacobs AC (1989) Multiple-site carcinogenicity of benzene in Fischer 344 rats and B6C3F1 mice. Environ Health Perspect 82: 125–163

    PubMed  CAS  Google Scholar 

  12. Kozak M (1983) Translation of insulin-related polypeptides from mRNAs with tandemly reiterated copies of the ribosome binding site. Cell 34: 971–978

    Article  PubMed  CAS  Google Scholar 

  13. Dunnick W, Elenich L, Berry J, Albrecht D, Stavnezer J, Claflin JL (1992) Regulation of switch recombination to the murine γl gene. In: Potter M, Melchers F (ed) Mechanisms in B Cell Neoplasia 1992. Springer Verlag, Berlin, pp 143–147

    Google Scholar 

  14. Seigler R, Rich MA (1968) Pathogenesis of reticulum cell sarcoma in mice. JNCI 41: 125–143

    Google Scholar 

  15. Heston WE (1964) Induction of mammary gland tumors in strain C57BL/He mice by isografts of hypophyses. JNCI 32: 947–955

    Google Scholar 

  16. Haupt Y, Harris AW, Adams JM (1992) Retroviral infection accelerates T lymphomagenesis in Eµ,-N-ras transgenic mice by activating c-myc or N-myc. Oncogene 7: 981–986

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology, The University of Michigan Medical School, Ann Arbor, MI, 48109-0620, USA

    Wesley Dunnick, Laura Elenich, Kirk Cunningham & Latham Claflin

  2. Unit for Laboratory Animal Medicine, The University of Michigan Medical School, Ann Arbor, MI, 48109-0620, USA

    Clarence Chrisp

Authors
  1. Wesley Dunnick
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  2. Laura Elenich
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  3. Kirk Cunningham
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  4. Clarence Chrisp
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  5. Latham Claflin
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Editor information

Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute National Institutes of Health, Bldg. 37, Rm. 2B04, 20892, Bethesda, MD, USA

    Michael Potter M.D. (Chief) (Chief)

  2. Institute for Immunology, Grenzacherstr. 487, CH-4005, Basel, Switzerland

    Fritz Melchers (Director) (Director)

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© 1995 Springer-Verlag Berlin Heidelberg

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Dunnick, W., Elenich, L., Cunningham, K., Chrisp, C., Claflin, L. (1995). Tumorigenesis in Mice with an SV40 T Antigen Transgene Driven by the Immunoglobulin γ1 Heavy Chain Germline Promoter. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1994. Current Topics in Microbiology and Immunology, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79275-5_20

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  • DOI: https://doi.org/10.1007/978-3-642-79275-5_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79277-9

  • Online ISBN: 978-3-642-79275-5

  • eBook Packages: Springer Book Archive

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