Abstract
The molecular analysis of specific chromosomal translocations has improved our understanding of the pathogenesis of various non-Hodgkin lymphoma (NHL) subtypes including follicular lymphoma (FL), Burkitt’s lymphoma (BL) and mantle-cell lymphoma, which are characterized by chromosomal translocations causing the deregulated expression of the BCL-2, C-MYC, and BCL-1, respectively (for review see Korsmeyer 1992, Dalla-Favera 1993, and Gaidano and Dalla-Favera 1992). However, relatively little is known about the molecular pathogenesis of diffuse large cell lymphoma (DLCL), the most frequent and most lethal human lymphoma (Magrath 1990). DLCL accounts for ~40% of initial NHL diagnoses and is often the final stage of progression of FL (Magrath 1990). Several molecular alterations have been detected at variable frequency in these tumors, but none has been specifically or consistently associated with the disease (Ladanyi et al. 1991, Offit et al. 1989a).
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References
Bastard C, Tilly H, Lenormand B, et al. (1992) Translocations involving band 3q37 and Ig gene regions in non-Hodgkin’s lymphoma. Blood 79: 2527–2531
Chardin P, Courtois G, Mattei MG, and Gisselbrecht S (1991) The KUP gene located on human chromosome 14 encodes a protein with two distinct zinc fingers. Nucleic Acid Res 19: 1431–1436
Chen Z, Brand NJ, Chen A et al. (1993) Fusion between a novel Kriippel- like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11:17) translocation associated with acute promyelocytic leukaemia. EMBO J 12: 1161–1167
Dalla-Favera R (1993) Chromosomal translocations involving the c-myc oncogene in lymphoid neoplasia. In: Kirsch IR (ed) The causes and consequences of chromosomal aberrations. Boca Raton: CRC Press, pp 313–332
de The’ H, Lavau C, Marchio A, et al. (1991) The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 66: 675–684.
DiBello PR, Withers DA, Bayer CA, Fristrom JW and Guild GM (1991) The Drosophila Broad-complex encodes a family of related proteins containing zinc fingers. 129: 385–397
Djabali M, Selleri L, Parry P, et al. (1992) A trithorax-like gene is interrupted by chromosome llq23 translocations in acute leukemias. Nature Genet 2: 113–118
El-Baradi T and Pieler T (1991) What we know and what we would like to know. Mech Dev 35: 155–169
Fichelson S, Dreyfus F, Berger R, et al. (1992) Evi-1 expression in leukemic patients with rearrangements of the 3q25–q28 chromosomal region. Leukemia 6: 93–99
Gaidano G and Dalla-Favera R (1992) Oncogenes and tumor suppressor genes. In: Knowles DM (ed) Neoplastic hematopathology. Baltimore: Wilkins & Wilkins, pp 245–261
Gu Y, Nakamura T, Alder H, et al. (1992) The t(4;ll) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 71: 701–708
Haber DA, Buckler AJ, Glaser T, et al. (1990) An internal deletion within an lip 13 zinc finger gene contributes to the development of Wilms1 tumor. Cell 61: 1257–1269
Harrison SD and Travers AA (1990) The tramtrack gene encodes a Drosophila finger protein that interacts with the ftz transcriptional regulatory region and shows a novel embryonic expression pattern. EMBO J 9: 207–216
Kakizuka A, Miller, Jr, WH, Umesono K, et al. (1991) Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML. Cell 663–674
Kerckaert JP, Deweindt C, Tilly H et al. (1993) LAZ-3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas. Nature Genet 5: 66–69
Korsmeyer SJ (1992) Bcl-2 initiates a new category of oncogenes: Regulators of cell death. Blood 80: 879–886
Ladanyi M, Offit K, Jhanwar SJ, et al. (1991) Myc rearrangements and translocations involving band 8q24 in diffuse large cell lymphomas. Blood 77: 1057–1063
Lo Coco F, Ye BH, Lista F et al. (1994) Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkin’s lymphoma. Blood 83: 1757–1759
Magrath IT (1990) The non-Hodgkin’s lymphomas: An introduction. In: Magrath IT (ed) The Non-Hodgkin’s lymphomas. Lodon: Edward Arnold, pp1–14
McGuire E, Hockett RD, Pollock KM, et al. (1989) The t(11;14)(pl5;ql 1) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. Mol Cell Biol 9: 2124–2132
Miki T, Kawamata N, Hirosawa S, and Aoki N (1994) Gene involved in the 3q27 translocation associated with B-cell lymphoma, BCL5, encodes a Kriippel-like zinc-finger protein. Blood 83: 26–32
Morishita K, Parker DS, Mucenski ML, et al. (1988) Retroviral activation of a novel gene encoding a zinc finger protein in IL3-dependent myeloid leukemia cell lines. Cell 54: 831–840
Offit K, Koduru PRK, Hollis R, et al. (1989a) 18q21 rearrangements in diffuse large cell lymphoma: Incidence and clinical significance. Brit J Haematol 72: 178–182
Offit K, Jhanwar S, Ebrahim S A D, et al. (1989b) t(3;22)(q27;qll): A novel translocation associated with diffuse non-Hodgkin’s lymphoma. Blood 74: 1876–1879
Offit K, Lo Coco F, Louie DC et al. (1994) Rearrangement of the bcl-6 gene as a prognostic marker in diffuse large-cell lymphoma. N Engl J Med (in press)
Pandolfi PP, Grignani F, Alcalay M, et al. (1991) Structure and origin of the acute promyelocytic leukemia myl/RARα cDNA and characterization of its retinoid-binding and transactivation properties. Oncogene 6: 1285–1292
Read D and Manley J (1992) Alternative transcripts of the Drosophila tramtrack gene encode zinc finger proteins with distinct DNA binding specificities. EMBO J 11: 1035–1044
Rosenberg UB, Schroder C, Preiss A, et al. (1986) Structural homology of the product of the Drosophila Kriippel gene with Xenopus transcription factor mA. Nature 319: 336–339
Tkachuk DC, Kohler S, Cleary ML. (1992) Involvement of a homolog of Drosophila Trithorax by llq23 chromosomal translocations in acute leukemias. Cell 71: 691–700
Ye BH, Rao PH, Chaganti RSK, and Dalla-Favera R (1993a) Cloning of bcl-6, the locus involved in chromosomal translocations affecting band 3q27 in B-cell lymphoma. Cancer Res. 53: 2732–2735
Ye BH, Lista F, Lo Coco F et al. (1993b) Alterations of a zinc finger- encoding gene, BCL-6, in diffuse large-cell lymphoma. Science 262: 747–750
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© 1995 Springer-Verlag Berlin Heidelberg
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Ye, B.H. et al. (1995). Alterations of the BCL-6 Gene in Diffuse Large-Cell Lymphoma. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1994. Current Topics in Microbiology and Immunology, vol 194. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79275-5_13
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DOI: https://doi.org/10.1007/978-3-642-79275-5_13
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