Replication: The Role of Escherichia coli Heat Shock Proteins in DNA Replication
Our understanding of how bacterial cells replicate their DNA originates from intensive studies of the modes of DNA replication used by bacteriophages and plasmids. The patterns of DNA replication and their control observed in bacteria have in turn been used as models to guide the investigation of DNA synthesis in more complex eukaryotic systems. What has emerged over the years is a remarkably detailed picture; one, however, that is by no means complete. The study of DNA replication continues to receive significant attention. Studies devoted to the relatively simple bacteriophage and plasmid models continue to provide new insights that are relevant to our understanding of prokaryotes and eukaryotes alike. The topic of this chapter is an example of such a recent contribution. Members of a large group of proteins, common to prokaryotes and eukaryotes, called molecular chaperones, have been found to interact with replication proteins important to bacteriophage and plasmids such that the replication activity is regulated. The specifics of those interactions will be described, as well as the relevance of this finding to the broader theme of cellular DNA replication.
KeywordsHeat Shock Protein Molecular Chaperone Heat Shock Response Heat Shock Gene Plasmid Replication
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