Hepatocyte Growth Factor and Its Variant with a Deletion of Five Amino Acids are Distinguishable in Biological, Physicochemical, and Immunochemical Properties

  • Nobuyuki Shima
  • Kanji Higashio
Part of the NATO ASI Series book series (volume 88)


Hepatocyte growth factor (HGF) (Nakamura et al., 1987; Gohda et al., 1988), also designated as scatter factor (Gherardi et al., 1989) or fibroblast-derived tumor cytotoxic factor (Higashio et al., 1990), is a heparin-binding basic protein with an approximate molecular mass of 80 kD. HGF is a disulfide-linked heterodimer composed of an a-chain of 52–56 kD and a β-chain of 30–34 kD. Recent studies have revealed that HGF not only functions as a mitogen for hepatocytes, it also stimulates the growth of various epithelial and endothelial cells (Rubin et al., 1991); it inhibits the growth of tumor cells (Higashio et al., 1990; Shima et al., 1991a); and it stimulates the mobility of epithelial (Gherardi et al., 1989) and endothelial cells (Rosen et al., 1990).


Hepatocyte Growth Factor Scatter Factor Human Aorta Smooth Muscle Cell Hepatocyte Growth Factor Receptor Kringle Domain 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Nobuyuki Shima
    • 1
  • Kanji Higashio
    • 1
  1. 1.Research Institute of Life ScienceSnow Brand Milk Products, Co., Ltd.Shimotsuga-gun, TochigiJapan

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