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Zytokine und ihre Bedeutung für Wundheilungsprozesse

  • Conference paper
Wundheilung — Wundverschluß

Part of the book series: Fortschritte der operativen und onkologischen Dermatologie ((OP.DERMATOLOGIE,volume 8))

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Zusammenfassung

Unter dem Begriff Zytokine versteht man Mediatoren, die unter normalen Bedingungen sowie im Verlauf von pathologischen Vorgängen Zellfunktionen regulieren und neuerdings auch zu Therapiezwecken eingesetzt werden. Zytokine werden von allen Zellen des Organismus gebildet und üben vielfältige, teilweise synergistische oder antagonistische Wirkungen aus, so daß die Existenz eines komplexen Netzwerkes angenommen werden muß. Im Rahmen der multiplen Vorgänge der Wundheilung bestehend aus Entzündungsreaktion und Gewebserneuerung spielen Zytokine eine entscheidende Rolle. Diese Mediatoren können von allen am Wundheilungsgeschehen beteiligten Zellen gebildet werden, wobei deren Synthese und Freisetzung durch Mikroorganismen, Matrixproteine und Zytokine selbst geregelt wird. Während Interleukine vorwiegend den Ablauf der Entzündungsreaktion beeinflussen, steuern Wachstumsfaktoren hauptsächlich Fibroplasie, Gewebserneuerung und Reepithelisierung. Die wichtige Rolle von Zytokinen im Rahmen der Wundheilung ist auch schon durch erste vielversprechende Ergebnisse bei deren Anwendung zur Behandlung von schlecht heilenden Wunden dokumentiert.

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Authors
  1. T. Luger
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Editors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Venerologie, Universität zu Köln, Joseph-Stelzmann-Straße 9, D-50924, Köln, Germany

    Gustav Mahrle , Hans-Joachim Schulze  & Thomas Krieg ,  & 

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© 1994 Springer-Verlag Berlin Heidelberg

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Luger, T. (1994). Zytokine und ihre Bedeutung für Wundheilungsprozesse. In: Mahrle, G., Schulze, HJ., Krieg, T. (eds) Wundheilung — Wundverschluß. Fortschritte der operativen und onkologischen Dermatologie, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79173-4_2

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  • DOI: https://doi.org/10.1007/978-3-642-79173-4_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79174-1

  • Online ISBN: 978-3-642-79173-4

  • eBook Packages: Springer Book Archive

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