Cancer cells divide at a faster rate than that at which they die, so that there is progressive growth of the tumour. There are other phenotypic features of pancreatic cancer that may also involve abnormalities of growth factors and their receptors. For instance, there is often a striking desmoplastic response in the stroma of the tumour, as well as marked neovascularisation. Exposure of pancreatic cells to various growth factors can profoundly alter their behaviour and responses. The identification of the growth factor receptor pathways involved in pancreatic tumorigenesis is important for our understanding of the biology of this tumour and will have implications for its diagnosis, classification and treatment.
KeywordsEpidermal Growth Factor Receptor Pancreatic Cancer Chronic Pancreatitis Pancreatic Cancer Cell Human Pancreatic Cancer
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