Advertisement

Growth Factors

  • N. R. Lemoine
Conference paper

Abstract

Cancer cells divide at a faster rate than that at which they die, so that there is progressive growth of the tumour. There are other phenotypic features of pancreatic cancer that may also involve abnormalities of growth factors and their receptors. For instance, there is often a striking desmoplastic response in the stroma of the tumour, as well as marked neovascularisation. Exposure of pancreatic cells to various growth factors can profoundly alter their behaviour and responses. The identification of the growth factor receptor pathways involved in pancreatic tumorigenesis is important for our understanding of the biology of this tumour and will have implications for its diagnosis, classification and treatment.

Keywords

Epidermal Growth Factor Receptor Pancreatic Cancer Chronic Pancreatitis Pancreatic Cancer Cell Human Pancreatic Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barton CM, Hall PA, Hughes CM, Gullick WJ, Lemoine NR (1991) Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer. J Pathol 163:111–116PubMedCrossRefGoogle Scholar
  2. Bussolino F, Di Renzo MF, Ziehe M, Bocchietto E, Olivero M, Naldini L, Gaudino G, Tamagnono L, Coffer A, Comoglio PM (1992) Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol 119:629 – 641PubMedCrossRefGoogle Scholar
  3. De Vries L, Tahiri-Jonti N, Bensaid M, Prats F, Viguerie N, Scemama JL, Tauber JP, Pradayrol L, Susini C, Vaysse N (1990) Regulation of proliferation by fibroblast growth factor in a pancreatic cancer cell line. Digestion 46:162–165PubMedCrossRefGoogle Scholar
  4. Di Renzo MF, Narsimhan RP, Olivero M, Bretti S, Giordano S, Medico E, Gaglia P, Zara P, Comoglio PM (1991) Expression of the MET/HGF receptor in normal and neoplastic human tissues. Oncogene 6:1997–2003PubMedGoogle Scholar
  5. Estival A, Louvel D, Coudere B, Prats H, Hollande E, Vaysse N, Clemente F (1993) Morphological and biological modifications induced in a rat pancreatic acinar cancer cell line (AR4-2J) by unscheduled expression of basic fibroblast growth factors. Cancer Res 53: 1182–1187PubMedGoogle Scholar
  6. Falls DL, Rosen KM, Corfas G, Lane WS, Fischbach GD (1993) ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the Neu ligand family. Cell 72:801–815PubMedCrossRefGoogle Scholar
  7. Friess H, Yamanaka Y, Kobrin MS, Buchler M, Beger H, Korc M (1993) Cytochemical and molecular evidence for overexpression of acidic fibroblast growth factor in the cancerous human pancreas. Gastroenterology 104:A304Google Scholar
  8. Glinsman-Gibson BJ, Korc M (1991) Regulation of transforming growth factor alpha mRNA expression in T3M4 human pancreatic carcinoma cell. Pancreas 6:142–149CrossRefGoogle Scholar
  9. Gutierrez A, Lemoine NR, Sikora K (1992) Gene therapy for cancer. Lancet 339:715–721PubMedCrossRefGoogle Scholar
  10. Hall PA, Hughes CM, Staddon SL, Richman PA, Gullick WJ, Lemoine NR (1990) The c-erbB-2 proto-oncogene in human pancreatic cancer. J Pathol 161:195–200PubMedCrossRefGoogle Scholar
  11. Holmes WE, Sliwkowski MX, Akita RW, Henzel WJ, Lee J, Park JW, Yansura D, Abadi N, Raab H, Lewis GD, Shepard HM, Kuang WJ, Wood WI, Goeddel DV, Vandlen RL (1992) Identification of hereguMn, a specific activator of p185erbB2. Science 256:1205–1210PubMedCrossRefGoogle Scholar
  12. Imanishi K, Yamaguchi K, Suzuki M, Honda S, Yanaihara N, Abe K (1989) Production of transforming growth factor-alpha in human tumour cell lines. Br J Cancer 59:761 – 765PubMedCrossRefGoogle Scholar
  13. Jhappen C, Stahle C, Harkins RN, Fausto N, Smith GH, Merlino GT (1990) TGF-alpha over-expression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas. Cell 61:1137–1146CrossRefGoogle Scholar
  14. Kalthoff F, Roeder C, Humburg I, Thiele HG, Greten H, Schmiegel W (1991) Modulation of platelet-derived growth factor A- and B-chain/c-sis mRNA by tumor necrosis factor and other agents in adenocarcinoma cells. Oncogene 6:1015–1021PubMedGoogle Scholar
  15. Kalthoff H, Roeder C, Schmiegel W (1993) Expression and regulation of erbB-2 in pancreatic adenocarcinoma cells and comparison with erbB-1/EGFR. In: Lohring T, Jonat W (eds) International symposium on the clinical and scientific relevance of HER2/neu/erbB-2. Springer, Berlin Heidelberg New YorkGoogle Scholar
  16. Korc M, Magun B (1985) Recycling of experimental growth factor in a human pancreatic carcinoma cell line. Proc Natl Acad Sci USA 82:6172–6175PubMedCrossRefGoogle Scholar
  17. Korc M, Finman JE (1989) Attenuated processing of epidermal growth factor in the face of marked degradation of transforming growth factor alpha. J Biol Chem 264:14990–14999PubMedGoogle Scholar
  18. Korc M, Chandrasekar B, Yamanaka Y, Friedd H, Buchler M, Beger HG (1992) Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increase in the levels of epidermal growth factor and transforming growth factor alpha. J Clin Invest 90:1352–1360PubMedCrossRefGoogle Scholar
  19. Lemoine NR, Hall PA (1990) Oncogenes and growth factor in pancreatic cancer. Baillieres Clin Gastroenterol 4:815 – 832PubMedCrossRefGoogle Scholar
  20. Lemoine NR, Sikora K (1993) Interventional genetics and the treatment of Cancer. Br Med J 306:665–666CrossRefGoogle Scholar
  21. Lemoine NR, Hughes CM, Barton CM, Poulson RA, Jeffery RE, Klöppel G, Hall PA, Gullick WJ (1992 a) The epidermal growth factor receptor in human pancreatic cancer. J Pathol 166:7–12PubMedCrossRefGoogle Scholar
  22. Lemoine NR, Lobresco M, Leung HY, Barton CM, Prigent SA, Gullick WJ, Klöppel G (1992b) The ERBB3 gene in human pancreatic cancer. J Pathol 168:269–273CrossRefGoogle Scholar
  23. Leung HY, Hughes CM, Gullick WJ, Lemoine NR (1983) Expression of fibroblast growth factor and their receptors in human pancreatic cancer. J Pathol 170 [Suppl] : 21Google Scholar
  24. Marchionni MA, Goodearl ADJ, Chen MS, Bermingham-McDonogh O, Kirk C, Hendricks M et al. (1993) Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature 362:312–318PubMedCrossRefGoogle Scholar
  25. Oustry P, Estival A, Pradayrol L, Vaysse N, Clémente F (1990) Two subclasses of EGF receptors in the human pancreatic cancer cell lines CAPAN-i and MIA PaCa-2. Int J Pancreatol 6:119–128PubMedGoogle Scholar
  26. Ozawa S, Ueda M, Ando N, Abe O, Shimuzu N (1988) Epidermal growth factor receptors in cancer tissues of esophagus, lung, pancreas, colorectum, breast and stomach. Jpn J Cancer Res 79:1201 –1207PubMedCrossRefGoogle Scholar
  27. Prigent SA, Lemoine NR (1992) The type 1 (EGF receptor-related) family of growth factors and their ligands. Prog Growth Factor Res 4:1–24PubMedCrossRefGoogle Scholar
  28. Sandgren EP, Luetteke NC, Palmiter RD, Brinster RL, Lee DC (1990) Overexpression of TGF-alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell 61:1121 –1135PubMedCrossRefGoogle Scholar
  29. Sandgren EP, Luetteke NC, Qiu TH, Palmiter RD, Brinster RL, Lee D.C (1993) Transforming growth factor alpha dramatically enhances oncogene-induced carcinogenesis in transgenic mouse pancreas and liver. Mol Cell Biol 13:320–330PubMedGoogle Scholar
  30. Schmiegel W, Roeder C, Schmielau J, Rodeck U, Kalthoff H (1993) Tumour necrosis factor alpha induces the expression of transforming growth factor alpha and the epidermal growth factor receptor in human pancreatic cancer cells. Proc Natl Acad Sci USA 90:863 – 867PubMedCrossRefGoogle Scholar
  31. Shing Y, Christofori G, Hanahan D, Ono Y, Sasada R, Igarashi K, Folkman J (1993) Betacellulin: a mitogen from pancreatic β cell tumours. Science 259:1604–1607PubMedCrossRefGoogle Scholar
  32. Smith JJ, Derynck R, Korc M (1987) Production of transforming growth factor alpha in humanGoogle Scholar
  33. pancreatic cancer cells: evidence for a superagonist autocrine cycle. Proc Natl Acad Sci USA 84:7567–7570Google Scholar
  34. Tsuda H, Iwase T, Matsumoto K, Ito M, Hirono I, Nishida Y, Yamamoto M, Tatematsu M, Matsumoto K, Nakamura T (1992) Immunohistochemical localisation of hepatocyte growth factor protein in pancreas islet cell A-cells of man and rats. Jpn J Cancer Res 83:1262–1266PubMedCrossRefGoogle Scholar
  35. Welter C, Theisinger B, Seitz G, Tomasetto C, Rio MC, Chambon P, Blin N (1992) Association in the human spasmolytic polypeptide and an estrogen-induced breast cancer protein (pS2) with human pancreatic carcinoma. Lab Invest 66:187–192PubMedGoogle Scholar
  36. Wen D, Peles E, Cupples R, Suggs SV, Bacus SS, Luo Y, Trail G, Hu S, Silbiger Sm, Levy RB, Koski RA, Lu HS, Yarden Y (1992) Neu differentiation factor: a transmembrane glycoprotein containing an EGF domain and an immunoglobulin homology unit. Cell 69:559–572PubMedCrossRefGoogle Scholar
  37. Williams TM, Weiner DB, Greene MI, Maguire HC (1991) Expression of c-erbB-2 in human pancreatic adenocarcinomas. Pathobiology 59:46 –52PubMedCrossRefGoogle Scholar
  38. Yamanaka Y (1992) The immunohistochemical expression of epidermal growth factors, epidermal growth factor receptors and c-erbB-2 oncoprotein in human pancreatic cancer. J Nippon Med Sch 59:51 – 61Google Scholar
  39. Yamanaka Y, Friess H, Kobrin MS, Buchler M, Beger HG, Korc M (1993 a) Overexpression of the c-erbB-2 oncogene in human pancreatic carcinomas correlates with well-differentiated histological grading. Gastroenterology 104:A344Google Scholar
  40. Yamanaka Y, Friess H, Buchler M, Neger HG, Gold LI, Korc M (1993b) Synthesis and expression of transforming growth factor β-1, β-2 and β-3 in the endocrine and exocrine pancreas. Diabetes 42:746 – 756CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • N. R. Lemoine

There are no affiliations available

Personalised recommendations