Skip to main content
SpringerLink
Log in

Opinion from Italy

  • Conference paper
Facing the Pancreatic Dilemma

  • 55 Accesses

Abstract

The Marseille-Rome classification appears to establish definitively the distinctive features of the various forms of chronic pancreatitis (CP). Essentially, the forms of CP with a lithogenic potential (chronic calcifying pancreatitis or pancreatic lithiasis) (CCP) are distinguished from other forms of the disease such as inflammatory CP, pancreatic fibrosis and chronic obstructive pancreatitis (COP) with different inflammatory components, all considered as being devoid of lithiasic characteristics [1]. The lithogenesis in the former chronic pancreatitis group is thought to be related mainly to pathogenetic mechanisms which are absent in the other forms of the disease, such as defective production and/or secretion of lithostatin (LS; a lectin-like protein which stabilizes the calcium present in pancreatic juice) or factors capable of influencing lithostatin secretion [2].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Sarles H (1991) Definitions and classifications of pancreatitis. Pancreas 6:470 – 474

    Article  PubMed  CAS  Google Scholar 

  2. Sarles H, Bernard JP (1991) Lithostatin and pancreatic lithogenesis. Gastroenterol Int 4:130–134

    Google Scholar 

  3. Sahel J, Cros RC, Durbec JP, Sarles H et al. (1986) Multicenter pathological study of chronic pancreatitis: morphological regional variations and differences between chronic alcifying pancreatitis and obstructive pancreatitis. Pancreas 6:471 – 477

    Article  Google Scholar 

  4. De Angelis C, Valente G, Spaccapietra M et al. (1992) Histological study of alcoholic, nonalcoholic, and obstructive chronic pancreatitis. Pancreas 2:193–196

    Article  Google Scholar 

  5. Konishi K, Ryohei I, Kato O et al. (1981) Experimental pancreolithiasis in the dog. Surgery 6:687–691

    Google Scholar 

  6. Sakakibara A, Okumura N, Hayakawa T, Kanzaki M (1982) Ultrastructural changes in the exocrine pancreas of experimental pancreolithiasis in dogs. Am J Gastroenterol 77: 498–503

    PubMed  CAS  Google Scholar 

  7. Tanaka T, Ichiba Y, Miura Y, Itoh H, Dohi K (1990) Pathogenesis of chronic alcoholic pancreatitis. Am J Gastroenterol 85:1536–1537

    PubMed  CAS  Google Scholar 

  8. Pap A, Boros L (1989) Alcohol-induced chronic pancreatitis in rats after temporary occlusion of biliopancreatic ducts with Ethibloc. Pancreas 4:249–255

    Article  PubMed  CAS  Google Scholar 

  9. Cotton PB, Sarner M (1984) International workshop on pancreatitis. Cambridge. In: Gyr KE, Singer MV, Sarles H (eds) Pancreatitis. Concepts and classification. Excerpta Medica, Amsterdam pp 239 – 241

    Google Scholar 

  10. Sarles H, Laugier R, Boustire C (1983) Pancreatic lithiasis. Alcoholic pancreatic pathogenesis. In: Jerzy Gass CB, Sherlock P (eds) Progress in gastroenterology, vol 4. Grune and Stratton, New York, pp 189 – 212

    Google Scholar 

  11. Cavallini G, Talamini G, Vaona B et al. (1994) Effect of alcohol and smoking on pancreatic lithogenesis in course of chronic pancreatitis. Pancreas 9(1): 42–46

    Article  PubMed  CAS  Google Scholar 

  12. Steer M (1989) Classification and pathogenesis of pancreatitis. Surg Clin North Am 4: 249–255

    Google Scholar 

  13. Bernard JP, Adrich Z, Montaldo G et al. (1991) Immunoreactive forms of pancreatic stone protein in six mammalian species. Pancreas 6:162–167

    Article  PubMed  CAS  Google Scholar 

  14. Scuro LA, Cavallini G (1990) La patologia infiammatoria del pancreas. Nosografia clinica: revisione clinica e contributo di gruppo. Atti del XCI congresso nazionale della SIMI, Taormina. Pozzi, Roma, pp 483 – 634

    Google Scholar 

  15. Miyaké H, Harada H, Kunichika K et al. (1987) Clinical course and prognosis of chronic pancreatitis. Pancreas 2:378–385

    Article  PubMed  Google Scholar 

  16. Bernades P, Belghiti J, Athouel M et al. (1983) Histoire naturelle de la pancreatite chronique: etude in 120 cas. Gastroenterol Clin Biol 7:8 –13

    PubMed  CAS  Google Scholar 

  17. Amman RW, Akovbiantz A, Largiader F et al. (1984) Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients. Gastroenterology 86:820 – 828

    Google Scholar 

  18. Nagata A, Homma T, Tamai K et al. (1981) A study of chronic pancreatitis by serial endoscopic pancreatography. Gastroenterology 81:884–891

    PubMed  CAS  Google Scholar 

  19. Lebenthal L, Lerner A, Heitlinger L (1986) The pancreas in cystic fibrosis. In: Go VLW, Garnder JD, Brooks FP et al. (eds) The exocrine pancreas: biology, pathobiology, and diseases. Raven, New York pp 783 – 817

    Google Scholar 

  20. Allen R, Raggenstoss A (1955) The pathogenesis of fibrocystic disease of the pancreas. Study of the ducts by serial section. Am J Pathol 31:337–351

    PubMed  CAS  Google Scholar 

  21. Bovo P, Mirachian R, Merigo F et al. (1987) HLA molecule expression on chronic pancreatitis specimens: is there a role for autoimmunity? A preliminary study. Pancreas 2:350 – 356

    Article  PubMed  CAS  Google Scholar 

  22. Bedossa P, Bacci J, Lemaigre G, Martin E (1990) Lymphocyte subsets and HLA-DR expression in normal pancreas and chronic pancreatitis. Pancreas 5:415 – 420

    Article  PubMed  CAS  Google Scholar 

  23. Jalleh RP, Gilbertson JA, Williamson RCN et al. (1993) Expression of major histocompa-tibility antigens in human chronic pancreatitis. Gut 34:1452–1457

    Article  PubMed  CAS  Google Scholar 

  24. Brandau HS, Dani R, Nogueira CD (1984) Chronic calcifying pancreatitis in Belo Horizonte, Brazil. A pathological study of 100 cases. Evidence for a possible immunological reaction. In: Gyr K, Singer MV, Sarles H (eds) Pancreatitis. Concepts and classification. Excerpta Medica, Amsterdam, pp 51–56

    Google Scholar 

  25. Chapman RW (1991) Role of the immune factors in the pathogenesis of primary sclerosing cholangitis. Semin Liv Dis 11:1 – 4

    Article  CAS  Google Scholar 

  26. Cavallini G (1993) Is chronic pancreatitis a primary disease of the pancreatic ducts? A new pathogenetic hypothesis. Ital J Gastroenterol 25:391 – 396

    PubMed  CAS  Google Scholar 

  27. Warren KW, Athanassiades S, Monge JI (1966) Primary sclerosing cholangitis. A study of forty-two cases. Am J Surg 111:23 – 46

    Article  PubMed  CAS  Google Scholar 

  28. Wiesner RH, LaRusso NF (1980) Clinicopathologic features of the syndrome of primary sclerosing cholangitis. Gastroenterology 79:200 – 206

    PubMed  CAS  Google Scholar 

  29. Chapman RWG, Marborgh BÅ, Rhodes JM et al. (1980) Primary sclerosing cholangitis. A review of its clinical features, cholangiography and hepatic histology. Gut 21:870 – 877

    Article  PubMed  CAS  Google Scholar 

  30. Lefkowitch JH (1982) Primary sclerosing cholangitis. Arch Intern Med 142:1157–1160

    Article  PubMed  CAS  Google Scholar 

  31. LaRusso NF, Wiesner RH, Ludwig J, MacCarty RL (1984) Primary sclerosing cholangitis. N Engl J Med 310:899 – 903

    Article  PubMed  CAS  Google Scholar 

  32. Heizberg JH, Petersen JM, Boyer HL (1987) Improved survival with primary sclerosing cholangitis. A review of clinicopathologic features and comparison of symptomatic and asymptomatic patients. Gastroenterology 92:1869 –1875

    Google Scholar 

  33. Porayko MK, Wiesner RH, LaRusso NF et al. (1990) Patients with asymptomatic primary sclerosing cholangitis frequently have progressive disease. Gastroenterology 98:1594–1602

    PubMed  CAS  Google Scholar 

  34. Farrant JM, Hayllar KM, Wilkinson ML et al. (1991) Natural history and prognostic variables in primary sclerosing cholangitis. Gastroenterology 100:1710–1717

    PubMed  CAS  Google Scholar 

  35. McLan JM (1979) Embryology of the pancreas. Saunders, London, pp 3 –14

    Google Scholar 

  36. Waldram R, Kopelman H, Tsantoulas D, Williams R (1975) Chronic Pancreatitis, sclerosing cholangitis and sicca complex in two siblings, Lancet i:550–552

    Article  Google Scholar 

  37. Børkje B, Vetvik K, Údegard S et al. (1985) Chronic pancreatitis in patients with sclerosing cholangitis and ulcerative colitis. Scand J Gastroenterol 20:539–542

    Article  PubMed  Google Scholar 

  38. Warwick F, Anderson RJL, Braganza JM (1985) Sclerosing-cholangitis-like changes in pancreatic disease. Clin Radiol 36:51 – 56

    Article  PubMed  CAS  Google Scholar 

  39. Lowenfels A, Maisonneuve P, Cavallini G et al. (1993) Pancreatitis and risk of pancreatic cancer. N Engl J Med 328(20) : 1433 –1437

    Article  PubMed  CAS  Google Scholar 

  40. Seyrig JA, Jian R, Modigliani R et al. (1985) Idiopathic pancreatitis associated with inflammatory bowel disease. Dig Dis Sci 30:1121 –1126

    Article  PubMed  CAS  Google Scholar 

  41. Angelini G, Cavallini G, Bovo P et al. (1988) Pancreatic function in chronic inflammatory bowel disease. Int J Pancreatol 3:185 –193

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. G. Cavallini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. Di Francesco
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Bovo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. Vaona
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Filippini
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. L. Frulloni
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M. Marcori
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. L. Rigo
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. M. P. Brunori
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. M. C. Andreaus
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Surgery, University of Verona Borgo Roma Hospital, I-37134, Verona, Italy

    Paolo Pederzoli M. D. (Prof.), Giorgio Cavallini M. D. (Prof.), Claudio Bassi M.D.  & Massimo Falconi M.D. (Prof.),  (Prof.),  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Cavallini, G. et al. (1994). Opinion from Italy. In: Pederzoli, P., Cavallini, G., Bassi, C., Falconi, M. (eds) Facing the Pancreatic Dilemma. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79167-3_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-79167-3_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58284-7

  • Online ISBN: 978-3-642-79167-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation