Skip to main content
SpringerLink
Log in
Book cover

Endoscopy pp 1–7Cite as

Endoscopic Fibrin Sealing in Gastroduodenal Ulcer Hemorrhage

  • Conference paper

  • 75 Accesses

Part of the book series: Fibrin Sealing in Surgical and Nonsurgical Fields ((ADMERE,volume 8))

Abstract

Patients with bleeding upper gastrointestinal ulcers were observed during the period 1989–1991. The clinical outcome was examined by retrospective analysis. Of all patients with benign gastric or duodenal ulcers, 85 patients presented with stigmata of bleeding, e.g., Forrest grades Ia-IIb. This group was treated endoscopically by the injection of fibrin sealant with or without additional hypertonic saline plus epinephrine. Endoscopic therapeutic procedures were repeated until the ulcers reached Forrest grade III. While initial hemostasis was achieved in all patients, permanent hemostasis declined to 85.9% in our series. The overall bleeding-associated mortality was 7.0%, and in 9.4% continuous bleeding required surgery. No therapy-associated complications were seen. Interestingly, fibrin glue f to induce a rapid healing process. It may be concluded that fibrin sealing is a complication-free highly effective endoscopic therapy.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Jiranek GC, Silverstein FE (1990) Introduction to endoscopic therapy for bleeding peptic ulcers. Gastrointest Endosc 36: 25–29

    Google Scholar 

  2. Benjamin SB (1990) Therapeutic endoscopy and bleeding ulcers: methodology. Gastrointest Endosc 36: 56–61

    Article  Google Scholar 

  3. Sugawa C (1990) Injection therapy for the control of bleeding ulcers. Gastrointest Endosc 36: 50–52

    Google Scholar 

  4. Laine L (1990) Bipolar/multipolar electrocoagulation. Gastrointest Endosc 36: 38–41

    Google Scholar 

  5. Papp JP (1990) Monopolar and electrohydrothermal treatment of upper gastrointestinal bleeding. Gastrointest Endosc 36: 34–37

    Article  Google Scholar 

  6. Jensen DM (1990) Heat probe for hemostasis of bleeding peptic ulcers: techniques and results of randomized controlled trials. Gastrointest Endosc 36: 42–49

    Google Scholar 

  7. Cotton PB (1990) Argon laser/Co2 treatment of bleeding ulcers. Gastrointestinal Endosc 36: 32–33

    Google Scholar 

  8. Swain P (1990) Nd: YAG laser: the pro approach. Gastrointest Endosc 36: 30–31

    Article  Google Scholar 

  9. Peura DA (1990) Topical therapy for the control of gastrointestinal bleeding. Gastrointest Endosc 36: 53–55

    Google Scholar 

  10. Soehendra N, Grimm H, Stenzel M (1985) Injection of non-variceal bleeding lesions of the upper gastrointestinal tract. Endoscopy 17: 129–132

    Article  PubMed  CAS  Google Scholar 

  11. Forrest JA, Finlayson NDC, Shearman DJC (1974) Endoscopy in gastrointestinal bleeding. Lancet II: 394–397

    Google Scholar 

  12. Heldwein WJ, Schreiner J, Pedrazzoli J, Lehnert P (1989) Is the Forrest classification a useful tool for planning endoscopic therapy of bleeding peptic ulcers? Endoscopy 21: 258–262

    Article  PubMed  CAS  Google Scholar 

  13. Lin H-J, Lee F-Y, Tsai Y-T, Lee S-D, Lee C-H (1990) What kind of non-bleeding visible vessel in a peptic ulcer needs aggressive therapy? Endoscopy 22: 8

    Article  PubMed  CAS  Google Scholar 

  14. Gilbert DA (1990) Epidemiology of upper gastrointestinal bleeding. Gastrointest Endosc 36: 8–13

    Google Scholar 

  15. Johnston JH (1990) Endoscopic risk factors for bleeding peptic ulcer. Gastrointest Endosc 36: 16–20

    Google Scholar 

  16. Panés J, Forné M, Marco C, Viver J, Garcia-Olivares E, Garau J (1987) Controlled trial of endoscopic sclerosis in bleeding peptic ulcers. Lancet 5: 1292–1294

    Article  Google Scholar 

  17. Chung SCS, Leung JWC, Steele RJC, Crofts TJ, Li AKC (1988) Endoscopic injection of adrenaline for actively bleeding ulcers: a randomised trial. Br Med J 296: 1631–1633

    Article  CAS  Google Scholar 

  18. Balanzó J, Sainz S, Espinós JC, Guarner C, Cussó X, Monés J, Vilardell F (1988) Endoscopic hemostasis by local injection of epinephrine and polidocanol in bleeding ulcer. A prospective randomized trial. Endoscopy 20: 289–291

    Google Scholar 

  19. Rutgeerts P, Broeckaert L, Janssens J, Vantrappen G, Coremans G, Hiele M (1989) Comparison of endoscopic polidocanol injection and YAG laser therapy for bleeding peptic ulcers. Lancet 27: 1164–1167

    Article  Google Scholar 

  20. Panés J, Forné M, Bágena F, Viver J (1990) Endoscopic sclerosis in the treatment of bleeding peptic ulcers with a visible vessel. Am J Gastroenterol 85: 252–254

    PubMed  Google Scholar 

  21. Winkeltau G, Arlt G, Treutner K-H, Schubert T, Schumpelick V (1990) Endoscopic therapy and early elective operation as a therapeutic regimen in ulcer bleeding. Hepatogastroenterology 37: 121–123

    PubMed  CAS  Google Scholar 

  22. Waring JP, Sanowski RA, Sawyer RL, Woods A, Foutch PG (1991) A randomized comparison of multipolar electrocoagulation and injection sclerosis for the treatment of bleeding peptic ulcer. Gastrointest Endosc 37: 295–298

    Article  PubMed  CAS  Google Scholar 

  23. Steele RJC, Park KGM, Crofts TJ (1991) Adrenaline injection for endoscopic hemostasis in non-variceal upper gastrointestinal haemorrhage. Br J Surg 78: 477–479

    Article  PubMed  CAS  Google Scholar 

  24. Rajgopal C, Palmer KR (1991) Endoscopic injection sclerosis: effective treatment for bleeding peptic ulcer. Gut 32: 727–729

    Article  PubMed  CAS  Google Scholar 

  25. Rutgeerts P, Geboes P, Vantrappen G (1989) Experimental studies of injection therapy for severe nonvariceal bleedings in dogs. Gastroenterology 997: 610–621

    Google Scholar 

  26. Salm R, Sontheimer J, Laaff H, Cegla M (1989) Tissue reaction and hemostatic characteristics-fibrin sealant versus polidocanol: experimental and clinical results. In: Waclawiczek HW (ed) Progress in fibrin sealing. Springer, Berlin Heidelberg New York, pp 123–129

    Chapter  Google Scholar 

  27. Levy J, Khakoo S, Barton R, Vicary R (1991) Fatal injection sclerotherapy of a bleeding peptic ulcer. Lancet 337: 504

    Article  PubMed  CAS  Google Scholar 

  28. Chester JE, Hurley PR (1990) Gastric necrosis: a complication of endoscopic sclerosis for bleeding peptic ulcer. Endoscopy 22: 287

    Article  PubMed  CAS  Google Scholar 

  29. Loperfido S, Patelli G, La Torre L (1990) Extensive necrosis of gastric mucosa following injection therapy of bleeding peptic ulcer. Endoscopy 22: 285–286

    Article  PubMed  CAS  Google Scholar 

  30. Eimiller A (1988) Fibrinkleber als Sklerosierungsmittel bei blutenden Läsionen im Gastrointestinaltrakt. In: Manegold BC (ed) Fibrinklebung in der Endoskopie. Springer, Berlin Heidelberg New York, pp 79–84

    Chapter  Google Scholar 

  31. Groitl H, Scheele J (1987) Initial experience with the endoscopic application of fibrin tissue adhesive in the upper gastrointestinal tract. Surg Endosc 1: 93–97

    Article  PubMed  CAS  Google Scholar 

  32. Salm R, Sontheimer J, Cegla M, Rückauer K (1989) Endoskopische Fibrinkleber- Injektion zur Blutstillung beim peptischen Ulcus. Endoskopie Heute 3: 63–66

    Google Scholar 

  33. Friedrichs O, Beccu L, Knieriem H-J, Papen J, Sabinasz A (1990) Submucöse Fibrinklebung bei peptischen Blutungen. In: Häring R (ed) Gastrointestinale Blutung. Blackwell Ueberreuter, Berlin, pp 101–108

    Google Scholar 

  34. Friedrichs O, Papen J, Sabinasz A, Heppe M (1990) Submucöse Fibrinklebung der Ulcusblutung - hat sich das Konzept bewährt? Z Gastroenterol 28: 477 (abstract)

    Google Scholar 

  35. Prassler R, Hendrich H, Richter G, Barnert J, Wienbeck M (1991) Endoskopische Therapie mit Polidocanol und Fibrinkleber bei der akuten Ulcusblutung. Z Gastroenterol 29: 491 (abstract)

    Google Scholar 

  36. Fuchs K-H, Schaube H, Hamelmann H (1990). Die endoskopische Blutstillung mit der Injektionsmethode. In: Häring R (ed) Gastrointestinale Blutung. Blackwell Ueberreuter, Berlin, pp 89–96

    Chapter  Google Scholar 

  37. Balanzö J, Villanueva C, Sainz S, Espinös JC, Mendez C, Guarner C, Vilardell F (1990) Injection therapy of bleeding peptic ulcer. A prospective, randomized trial using epinephrine and thrombin. Endoscopy 22: 157–159

    Google Scholar 

  38. Fuchs K-H, Schaube H, Eckstein AK, Freys S (1989) Die endoskopische Hämostase. In: Henning H, Manegold BC (eds) Fortschritte der gastroenterologischen Endoskopie, vol 19. Demeter, Gräfelfing, pp 88–93

    Google Scholar 

  39. Benedetti G, Sablich R, Lacchin T (1991) Endoscopic injection sclerotherapy in nonvariceal upper gastrointestinal bleeding. Surg Endosc 5: 28–30

    Article  PubMed  CAS  Google Scholar 

  40. Swobodnik W, Kuhn K (1992) Elektronische Befunddokumentation, Leistungsstatistik und Bildanalysen in der Endoskopie. Z Gastroenterol 30: 202–203

    Google Scholar 

  41. Hirao M, Kobayashi T, Masuda K, Yamaguchi S, Nöda K, Matsuura K, Naka H, Kawauchi H, Namiki M (1985) Endoscopic local injection of hypertonic salineepinephrine solution to arrest hemorrhage from the upper gastrointestinal tract. Gastrointest Endosc 31: 313–317

    Article  PubMed  CAS  Google Scholar 

  42. Sarkar MR, Kienzle H-F, Bähr R (1992) Kann durch endoskopische Methoden die Letaütäts- und Komplikationsrate des blutenden Ulcus ventriculi bzw. duodeni gesenkt werden? Leber Magen Darm 1: 10–18

    Google Scholar 

  43. Cook DJ, Guyatt GH, Salena BJ, Laine LA (1992) Endoscopic therapy for acute nonvariceal upper gastrointestinal hemorrhage: a metaanalysis. Gastroenterology 102: 139–148

    PubMed  CAS  Google Scholar 

  44. Brunner G, Chang J (1990) Intravenous therapy with high doses of ranitidine and omeprazole in critically ill patients with bleeding peptic ulcerations of the upper intestinal tract: an open randomized controlled trial. Digestion 45: 217–225

    Article  PubMed  CAS  Google Scholar 

  45. Manegold BC (1988) Endoskopische Fibrinklebung. Endoskopie Heute 2: 22–24

    Google Scholar 

Download references

Authors
  1. G. Herold
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Preclik
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. F. Stange
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Ludwig-Boltzmann-Institut für experimentelle und klinische Traumatologie, Donaueschingenstraße 13, 1200, Wien, Austria

    Günther Schlag

  2. AKH Linz, II. Chirurgie, Krankenhausstraße 9, 4020, Linz, Austria

    Wolfgang Wayand

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Herold, G., Preclik, G., Stange, E.F. (1995). Endoscopic Fibrin Sealing in Gastroduodenal Ulcer Hemorrhage. In: Schlag, G., Wayand, W. (eds) Endoscopy. Fibrin Sealing in Surgical and Nonsurgical Fields, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79165-9_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-79165-9_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58282-3

  • Online ISBN: 978-3-642-79165-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation