Hormone Replacement Therapy and Hypertension: Relationship to the Renin-Angiotensin System
Senaca observed early in the first century A.D., “the illustrious founder of the guild and profession of medicine [Hippocrates] remarked that women never lost their hair or suffered from pain in the feet; and yet nowadays they run short of hair and are afflicted with gout … in rivalling male indulgences, they have also rivalled the ills to which men are heirs“.
KeywordsDepression Ischemia Estrogen Osteoporosis Angiotensin
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- 1.Centers for Disease Control and Prevention (1993) Annual summary of births, marriages, divorces, and deaths: United States, 1992. Monthly vital statistics report from the Centers for Disease Control and Prevention, vol 14, pp 1–24Google Scholar
- 6.Keaney JF, Shwaery GT, Xu A, Nicolosi RJ, Foxall TL, Vita JA (1993) Preserva¬tion of endothelial function in hypercholesterolemia through the antioxidant properties of estrogens. Circulation 88: 1–79Google Scholar
- 8.Magness RR, Rosenfeld CR (1989) Local and systemic estradiol- 17beta: effects on uterine and systemic vasodilation. Am J Physiol XX: E536–E542Google Scholar
- 10.Ravnikar VA (1993) Hormone replacement therapy in the primary prevention of cardiovascular disease: benefits, risks, and compliance issues. In: Wenger NK, Speroff L, Packard B (eds) Cardiovascular health and disease in women. Le Jacq Communications, Greenwich, pp 181–187Google Scholar
- 14.Russel RP, Sullivan MA (1970) The pill and hypertension. Johns Hopkins Med J 127: 287–293Google Scholar
- 15.Woods JW (1988) Oral contraceptives and hypertension. Hyertension 11 [Suppl II]: II. 11–II. 15Google Scholar
- 16.McCaffrey TA (1985) Preliminary dissertation. Purdue University, IndianaGoogle Scholar
- 24.Sealey JE, Blumenfeld JD, Bell GM, Pecker MS, Sommers SC, Laragh JH (1988) On the renal basis for essential hypertension: nephron heterogeneity with discordant renin secretion and sodium excretion causing a hypertensive vasoconstriction-volume relationship. J Hypertension 6: 763–777CrossRefGoogle Scholar
- 25.Sealey JE, Itskovitz-Eldor J, Rubattu S, James GD, August P, Thaler I, Levron J, Laragh JH (1993) Estradiol and progesterone related increases in the renin- aldosterone system during ovarian stimulation and early pregnancy (submitted to J Clin Endocrinol Metab )Google Scholar