Structure and Function of the VDAC Ion Channel
Mitochondria function within the cytoplasm of eukaryotic cells separated from the cytoplasm by a membranous barrier, the mitochondrial outer membrane. Permeability pathways in this membrane, such as the VDAC channels, can be viewed both as a means by which metabolites may travel from one compartment to the other and as a means of controlling the flux of such metabolites. Both of these functions depend on the properties of the permeating pathways, such as the VDAC channels. By examining in detail the properties of VDAC one should obtain insights into its role in mitochondrial function.
KeywordsOuter Membrane Cylindrical Shell Closed State Voltage Dependence Mitochondrial Outer Membrane
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