Insights Into the Structure of the Mitochondrial Channel, VDAC, Provided by Electron Microscopy

  • Carmen A. Mannella
Part of the NATO ASI Series book series (volume 83)


It has been ten years since publication of the finding that outer membranes isolated from mitochondria of the fungus Neurospora crassa may bear periodic arrays of stain-accumulating subunits, which were later identified as the voltage-dependent anion-selective channel, VDAC (Mannella, 1982). In the ensuing years, considerable progress has been made both in controlling the crystallization process and in characterizing the structure of the arrays. The aim of the present report is to summarize information about the structure of the VDAC channel that has been obtained from high-resolution electron microscopy and image analysis of these two-dimensional (2D) crystals.


Mitochondrial Outer Membrane Crystalline Array Electron Cryomicroscopy Mitochondrial Channel Electron Microscopy Society 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1994

Authors and Affiliations

  • Carmen A. Mannella
    • 1
  1. 1.Wadsworth Center for Laboratories and Research, New York State Department of Health, and Department of Biomedical Sciences School of Public HealthState University of New York at AlbanyAlbanyUSA

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